BRD-K19220233_JNK-9L_MCF10A_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-K19220233_JNK-9L_MCF10A_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK1 adenylate kinase 1
ANOS1 anosmin 1
ASPN asporin
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1
BTK Bruton agammaglobulinemia tyrosine kinase
C9ORF16 chromosome 9 open reading frame 16
CD36 CD36 molecule (thrombospondin receptor)
CKB creatine kinase, brain
COL10A1 collagen, type X, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
COMP cartilage oligomeric matrix protein
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EDNRB endothelin receptor type B
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FABP4 fatty acid binding protein 4, adipocyte
FASN fatty acid synthase
FLNA filamin A, alpha
KDM5D lysine (K)-specific demethylase 5D
LAPTM4B lysosomal protein transmembrane 4 beta
LOX lysyl oxidase
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRRC15 leucine rich repeat containing 15
LUM lumican
MAOA monoamine oxidase A
MLANA melan-A
MLF1 myeloid leukemia factor 1
NELL2 NEL-like 2 (chicken)
PECAM1 platelet/endothelial cell adhesion molecule 1
POSTN periostin, osteoblast specific factor
RAB31 RAB31, member RAS oncogene family
RPS4Y1 ribosomal protein S4, Y-linked 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC16A6 solute carrier family 16, member 6
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SORD sorbitol dehydrogenase
STEAP1 six transmembrane epithelial antigen of the prostate 1
STXBP1 syntaxin binding protein 1
STXBP2 syntaxin binding protein 2
TCTA T-cell leukemia translocation altered
TIMP3 TIMP metallopeptidase inhibitor 3
TM7SF2 transmembrane 7 superfamily member 2
TMSB15A thymosin beta 15a
TXNL4A thioredoxin-like 4A
TYR tyrosinase
WDR7 WD repeat domain 7
WSB2 WD repeat and SOCS box containing 2

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
AKR1C3 aldo-keto reductase family 1, member C3
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4B AT rich interactive domain 4B (RBP1-like)
BAMBI BMP and activin membrane-bound inhibitor
BID BH3 interacting domain death agonist
C4BPA complement component 4 binding protein, alpha
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCNF cyclin F
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CLK4 CDC-like kinase 4
CLP1 cleavage and polyadenylation factor I subunit 1
CLU clusterin
CP ceruloplasmin (ferroxidase)
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP6 dual specificity phosphatase 6
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EED embryonic ectoderm development
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA6 GATA binding protein 6
GCH1 GTP cyclohydrolase 1
HOXA10 homeobox A10
HOXA5 homeobox A5
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INTS6 integrator complex subunit 6
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
IVNS1ABP influenza virus NS1A binding protein
KCTD12 potassium channel tetramerization domain containing 12
KIF5C kinesin family member 5C
KIN Kin17 DNA and RNA binding protein
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT23 keratin 23, type I
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRIP1 nuclear receptor interacting protein 1
OAT ornithine aminotransferase
PCDH9 protocadherin 9
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PLAGL1 pleiomorphic adenoma gene-like 1
PLK2 polo-like kinase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMM2 phosphomannomutase 2
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTHLH parathyroid hormone-like hormone
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM15 RNA binding motif protein 15
RBM39 RNA binding motif protein 39
RGS2 regulator of G-protein signaling 2
RNF219 ring finger protein 219
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RYBP RING1 and YY1 binding protein
SAP30 Sin3A-associated protein, 30kDa
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SOX4 SRY (sex determining region Y)-box 4
SPP1 secreted phosphoprotein 1
SPRY2 sprouty homolog 2 (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TARP TCR gamma alternate reading frame protein
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
TP53BP2 tumor protein p53 binding protein 2
TSC22D2 TSC22 domain family, member 2
TSPYL5 TSPY-like 5
VNN1 vanin 1
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF22 zinc finger protein 22