BRD-K19220233_JNK-9L_MCF10A_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

195 genes differentially expressed following the BRD-K19220233_JNK-9L_MCF10A_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BEX1 brain expressed, X-linked 1
CALCOCO2 calcium binding and coiled-coil domain 2
CD34 CD34 molecule
CHL1 cell adhesion molecule L1-like
CLIC4 chloride intracellular channel 4
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL9A3 collagen, type IX, alpha 3
COMP cartilage oligomeric matrix protein
FABP4 fatty acid binding protein 4, adipocyte
FCGBP Fc fragment of IgG binding protein
GJA1 gap junction protein, alpha 1, 43kDa
GPM6A glycoprotein M6A
GPX3 glutathione peroxidase 3
GULP1 GULP, engulfment adaptor PTB domain containing 1
GYG2 glycogenin 2
HACD2 3-hydroxyacyl-CoA dehydratase 2
HOXC6 homeobox C6
IFITM1 interferon induced transmembrane protein 1
ITM2A integral membrane protein 2A
LAGE3 L antigen family, member 3
LAPTM4B lysosomal protein transmembrane 4 beta
LIMCH1 LIM and calponin homology domains 1
LYPLA1 lysophospholipase I
MAB21L2 mab-21-like 2 (C. elegans)
MAOA monoamine oxidase A
MCUR1 mitochondrial calcium uniporter regulator 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NRN1 neuritin 1
NTS neurotensin
OLFM1 olfactomedin 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PLCB4 phospholipase C, beta 4
PLS3 plastin 3
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
SCARB2 scavenger receptor class B, member 2
SDC2 syndecan 2
SEPT10 septin 10
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
STMN2 stathmin 2
SYT1 synaptotagmin I
TFPI2 tissue factor pathway inhibitor 2
TOM1L1 target of myb1 (chicken)-like 1
TPD52 tumor protein D52
TSPAN7 tetraspanin 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
ALB albumin
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARL4A ADP-ribosylation factor-like 4A
AURKA aurora kinase A
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BCL10 B-cell CLL/lymphoma 10
BTG2 BTG family, member 2
C14ORF169 chromosome 14 open reading frame 169
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2AIP CDKN2A interacting protein
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLP1 cleavage and polyadenylation factor I subunit 1
CNOT4 CCR4-NOT transcription complex, subunit 4
CREM cAMP responsive element modulator
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLRE1C DNA cross-link repair 1C
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DFNA5 deafness, autosomal dominant 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DOCK4 dedicator of cytokinesis 4
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EIF5 eukaryotic translation initiation factor 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
F5 coagulation factor V (proaccelerin, labile factor)
FADD Fas (TNFRSF6)-associated via death domain
FAM60A family with sequence similarity 60, member A
FASTKD5 FAST kinase domains 5
FBP1 fructose-1,6-bisphosphatase 1
FBXO34 F-box protein 34
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOXO1 forkhead box O1
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GAS1 growth arrest-specific 1
GATA6 GATA binding protein 6
GDF15 growth differentiation factor 15
GEMIN4 gem (nuclear organelle) associated protein 4
GNLY granulysin
GSPT2 G1 to S phase transition 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIC2 hypermethylated in cancer 2
HNMT histamine N-methyltransferase
HOXA10 homeobox A10
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER3 immediate early response 3
IER5 immediate early response 5
IRS2 insulin receptor substrate 2
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KLF4 Kruppel-like factor 4 (gut)
MAD2L1BP MAD2L1 binding protein
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MEPCE methylphosphate capping enzyme
MFSD5 major facilitator superfamily domain containing 5
MMP7 matrix metallopeptidase 7
MT1X metallothionein 1X
MT2A metallothionein 2A
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NGDN neuroguidin, EIF4E binding protein
NOTCH2 notch 2
NOV nephroblastoma overexpressed
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
OSR2 odd-skipped related transciption factor 2
PELO pelota homolog (Drosophila)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK2 polo-like kinase 2
POLR1C polymerase (RNA) I polypeptide C, 30kDa
PPIF peptidylprolyl isomerase F
PPP1R10 protein phosphatase 1, regulatory subunit 10
PPP1R3D protein phosphatase 1, regulatory subunit 3D
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RBM15 RNA binding motif protein 15
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RNF219 ring finger protein 219
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RYBP RING1 and YY1 binding protein
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERTAD3 SERTA domain containing 3
SESN1 sestrin 1
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMG8 SMG8 nonsense mediated mRNA decay factor
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
TACSTD2 tumor-associated calcium signal transducer 2
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNPO1 transportin 1
TOB2 transducer of ERBB2, 2
TSC22D2 TSC22 domain family, member 2
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
ZCCHC2 zinc finger, CCHC domain containing 2
ZEB1 zinc finger E-box binding homeobox 1
ZFAND5 zinc finger, AN1-type domain 5
ZFP36L1 ZFP36 ring finger protein-like 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZHX2 zinc fingers and homeoboxes 2
ZNF232 zinc finger protein 232
ZNF267 zinc finger protein 267