BRD-K19220233_JNK-9L_MCF10A_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

236 genes differentially expressed following the BRD-K19220233_JNK-9L_MCF10A_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIF1 allograft inflammatory factor 1
AKAP12 A kinase (PRKA) anchor protein 12
AKAP9 A kinase (PRKA) anchor protein 9
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ANGPTL2 angiopoietin-like 2
ANXA9 annexin A9
APOC2 apolipoprotein C-II
APOE apolipoprotein E
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
AQP1 aquaporin 1 (Colton blood group)
ATG12 autophagy related 12
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BACE1 beta-site APP-cleaving enzyme 1
BACE2 beta-site APP-cleaving enzyme 2
BLNK B-cell linker
BMP2 bone morphogenetic protein 2
BPHL biphenyl hydrolase-like (serine hydrolase)
C1ORF61 chromosome 1 open reading frame 61
C6ORF62 chromosome 6 open reading frame 62
CADM1 cell adhesion molecule 1
CALB1 calbindin 1, 28kDa
CALCRL calcitonin receptor-like
CCR1 chemokine (C-C motif) receptor 1
CD14 CD14 molecule
CD163 CD163 molecule
CD300A CD300a molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEP57 centrosomal protein 57kDa
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
CPE carboxypeptidase E
CTSB cathepsin B
CYBA cytochrome b-245, alpha polypeptide
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DOK5 docking protein 5
DSP desmoplakin
EFNB2 ephrin-B2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
EZR ezrin
FAM107A family with sequence similarity 107, member A
FAM46A family with sequence similarity 46, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GAP43 growth associated protein 43
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPM6A glycoprotein M6A
GPM6B glycoprotein M6B
GPNMB glycoprotein (transmembrane) nmb
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HBB hemoglobin, beta
HDAC9 histone deacetylase 9
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IL1R1 interleukin 1 receptor, type I
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JUP junction plakoglobin
KCTD12 potassium channel tetramerization domain containing 12
LAPTM5 lysosomal protein transmembrane 5
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00341 long intergenic non-protein coding RNA 341
LOC100505650 uncharacterized LOC100505650
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC17 leucine rich repeat containing 17
LRRN3 leucine rich repeat neuronal 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1C1 mannosidase, alpha, class 1C, member 1
MAPT microtubule-associated protein tau
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MATN2 matrilin 2
MBP myelin basic protein
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2C myocyte enhancer factor 2C
MXRA5 matrix-remodelling associated 5
NID1 nidogen 1
NMT2 N-myristoyltransferase 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NRCAM neuronal cell adhesion molecule
PAM peptidylglycine alpha-amidating monooxygenase
PAX8 paired box 8
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PEG3 paternally expressed 3
PFKL phosphofructokinase, liver
PHYH phytanoyl-CoA 2-hydroxylase
PLTP phospholipid transfer protein
PLVAP plasmalemma vesicle associated protein
PPAP2B phosphatidic acid phosphatase type 2B
PPARD peroxisome proliferator-activated receptor delta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
QPRT quinolinate phosphoribosyltransferase
RBP1 retinol binding protein 1, cellular
RCAN2 regulator of calcineurin 2
REEP5 receptor accessory protein 5
RHOBTB3 Rho-related BTB domain containing 3
RNASET2 ribonuclease T2
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SC5D sterol-C5-desaturase
SCGB2A2 secretoglobin, family 2A, member 2
SDC2 syndecan 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
ST18 suppression of tumorigenicity 18, zinc finger
STMN2 stathmin 2
SULF1 sulfatase 1
TENM4 teneurin transmembrane protein 4
TMEM45A transmembrane protein 45A
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRAK2 trafficking protein, kinesin binding 2
TRIM36 tripartite motif containing 36
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
TYROBP TYRO protein tyrosine kinase binding protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VTCN1 V-set domain containing T cell activation inhibitor 1
ZIC1 Zic family member 1
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AKAP1 A kinase (PRKA) anchor protein 1
ALCAM activated leukocyte cell adhesion molecule
AMIGO2 adhesion molecule with Ig-like domain 2
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA3 annexin A3
AQP3 aquaporin 3 (Gill blood group)
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CARD10 caspase recruitment domain family, member 10
CCNA2 cyclin A2
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CKS2 CDC28 protein kinase regulatory subunit 2
CMAHP cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene
COL9A3 collagen, type IX, alpha 3
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYCS cytochrome c, somatic
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DPYSL2 dihydropyrimidinase-like 2
ELAVL1 ELAV like RNA binding protein 1
EMG1 EMG1 N1-specific pseudouridine methyltransferase
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FSTL1 follistatin-like 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALE UDP-galactose-4-epimerase
GCH1 GTP cyclohydrolase 1
H2AFV H2A histone family, member V
HK1 hexokinase 1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
KIF14 kinesin family member 14
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT7 keratin 7, type II
KRT81 keratin 81, type II
LBR lamin B receptor
LDLR low density lipoprotein receptor
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MICALL1 MICAL-like 1
MRPS16 mitochondrial ribosomal protein S16
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
OAT ornithine aminotransferase
OPN3 opsin 3
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PCNA proliferating cell nuclear antigen
PLAC8 placenta-specific 8
PNP purine nucleoside phosphorylase
PPAP2C phosphatidic acid phosphatase type 2C
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
RGS13 regulator of G-protein signaling 13
SEPHS1 selenophosphate synthetase 1
SFRP1 secreted frizzled-related protein 1
SLIRP SRA stem-loop interacting RNA binding protein
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TBL1X transducin (beta)-like 1X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TXLNA taxilin alpha
TXN thioredoxin
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE3C ubiquitin protein ligase E3C
VIM vimentin
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta