BRD-K19220233_JNK-9L_MCF10A_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

199 genes differentially expressed following the BRD-K19220233_JNK-9L_MCF10A_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AQP1 aquaporin 1 (Colton blood group)
BASP1 brain abundant, membrane attached signal protein 1
C3 complement component 3
CALB1 calbindin 1, 28kDa
CCL5 chemokine (C-C motif) ligand 5
CD52 CD52 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD86 CD86 molecule
CDH3 cadherin 3, type 1, P-cadherin (placental)
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CLEC3B C-type lectin domain family 3, member B
CLU clusterin
COLEC12 collectin sub-family member 12
CSNK1D casein kinase 1, delta
CSTA cystatin A (stefin A)
CYB5R1 cytochrome b5 reductase 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DPT dermatopontin
DSP desmoplakin
EPAS1 endothelial PAS domain protein 1
EZR ezrin
FABP4 fatty acid binding protein 4, adipocyte
FAM107A family with sequence similarity 107, member A
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOLR1 folate receptor 1 (adult)
FTH1 ferritin, heavy polypeptide 1
GATA3 GATA binding protein 3
GPC1 glypican 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI27 interferon, alpha-inducible protein 27
IGFBP6 insulin-like growth factor binding protein 6
JAM2 junctional adhesion molecule 2
KRT6A keratin 6A, type II
LAPTM5 lysosomal protein transmembrane 5
LRMP lymphoid-restricted membrane protein
LRRN3 leucine rich repeat neuronal 3
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MMD monocyte to macrophage differentiation-associated
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MXRA5 matrix-remodelling associated 5
NCF2 neutrophil cytosolic factor 2
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRCAM neuronal cell adhesion molecule
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PPAP2B phosphatidic acid phosphatase type 2B
PPL periplakin
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)
RGCC regulator of cell cycle
RSL1D1 ribosomal L1 domain containing 1
S100A7 S100 calcium binding protein A7
SEC14L1 SEC14-like 1 (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERTAD2 SERTA domain containing 2
SFN stratifin
SGCE sarcoglycan, epsilon
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLPI secretory leukocyte peptidase inhibitor
SPAG4 sperm associated antigen 4
SPARCL1 SPARC-like 1 (hevin)
SPINT1 serine peptidase inhibitor, Kunitz type 1
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
SYT17 synaptotagmin XVII
TERT telomerase reverse transcriptase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM45A transmembrane protein 45A
TMOD1 tropomodulin 1
TNS1 tensin 1
TPPP3 tubulin polymerization-promoting protein family member 3
TRIM16 tripartite motif containing 16
TRIM8 tripartite motif containing 8
TSC22D3 TSC22 domain family, member 3
TUBB2B tubulin, beta 2B class IIb
WSCD1 WSC domain containing 1
XIST X inactive specific transcript (non-protein coding)
ZC3H11A zinc finger CCCH-type containing 11A

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA3 annexin A3
ATF5 activating transcription factor 5
AURKA aurora kinase A
BAZ1A bromodomain adjacent to zinc finger domain, 1A
CALD1 caldesmon 1
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNE2 cyclin E2
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTSH cathepsin H
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYCS cytochrome c, somatic
CYP4F3 cytochrome P450, family 4, subfamily F, polypeptide 3
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF5A eukaryotic translation initiation factor 5A
ETV1 ets variant 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GGCT gamma-glutamylcyclotransferase
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTPBP8 GTP-binding protein 8 (putative)
HAT1 histone acetyltransferase 1
HIST1H4C histone cluster 1, H4c
HMGB1 high mobility group box 1
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
ITM2A integral membrane protein 2A
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP7 microtubule-associated protein 7
MAPK13 mitogen-activated protein kinase 13
MMP9 matrix metallopeptidase 9
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NBN nibrin
NME4 NME/NM23 nucleoside diphosphate kinase 4
OAT ornithine aminotransferase
PBK PDZ binding kinase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PTHLH parathyroid hormone-like hormone
RAD51AP1 RAD51 associated protein 1
RANBP1 RAN binding protein 1
RBM25 RNA binding motif protein 25
RNF130 ring finger protein 130
RRM2 ribonucleotide reductase M2
SCML1 sex comb on midleg-like 1 (Drosophila)
SEPT11 septin 11
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SKP1 S-phase kinase-associated protein 1
SMC4 structural maintenance of chromosomes 4
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPC25 SPC25, NDC80 kinetochore complex component
SRSF3 serine/arginine-rich splicing factor 3
SRSF7 serine/arginine-rich splicing factor 7
STMN1 stathmin 1
SUB1 SUB1 homolog (S. cerevisiae)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM123 transmembrane protein 123
TMPO thymopoietin
TOR1AIP1 torsin A interacting protein 1
TRA2A transformer 2 alpha homolog (Drosophila)
TTK TTK protein kinase
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
USP1 ubiquitin specific peptidase 1
VRK1 vaccinia related kinase 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZDHHC6 zinc finger, DHHC-type containing 6