BRD-K19220233_JNK-9L_LNCAP_3_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

106 genes differentially expressed following the BRD-K19220233_JNK-9L_LNCAP_3_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADGRF5 adhesion G protein-coupled receptor F5
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CFH complement factor H
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
COL3A1 collagen, type III, alpha 1
CXCL10 chemokine (C-X-C motif) ligand 10
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
F2R coagulation factor II (thrombin) receptor
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
ICAM1 intercellular adhesion molecule 1
IDO1 indoleamine 2,3-dioxygenase 1
ITM2A integral membrane protein 2A
MGLL monoglyceride lipase
OSBPL10 oxysterol binding protein-like 10
OXTR oxytocin receptor
PPL periplakin
RAI14 retinoic acid induced 14
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
TERT telomerase reverse transcriptase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TSPAN8 tetraspanin 8
WNT5A wingless-type MMTV integration site family, member 5A

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALOX5 arachidonate 5-lipoxygenase
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CAST calpastatin
CD24 CD24 molecule
CDC25A cell division cycle 25A
CDC42 cell division cycle 42
CDCA4 cell division cycle associated 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFLAR CASP8 and FADD-like apoptosis regulator
CKS2 CDC28 protein kinase regulatory subunit 2
CPA3 carboxypeptidase A3 (mast cell)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DEFB1 defensin, beta 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FASTKD5 FAST kinase domains 5
FBLN1 fibulin 1
GATA2 GATA binding protein 2
GLIPR1 GLI pathogenesis-related 1
GPM6B glycoprotein M6B
GSPT2 G1 to S phase transition 2
H2AFX H2A histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIC2 hypermethylated in cancer 2
HOXA5 homeobox A5
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER5 immediate early response 5
JUN jun proto-oncogene
KLF2 Kruppel-like factor 2
KLF9 Kruppel-like factor 9
KLHL9 kelch-like family member 9
KRT19 keratin 19, type I
KRT5 keratin 5, type II
LGALS1 lectin, galactoside-binding, soluble, 1
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MMP7 matrix metallopeptidase 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOP56 NOP56 ribonucleoprotein
NXT1 nuclear transport factor 2-like export factor 1
OAT ornithine aminotransferase
OLFM4 olfactomedin 4
PCP4 Purkinje cell protein 4
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRNP prion protein
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRO protein tyrosine phosphatase, receptor type, O
RGCC regulator of cell cycle
RHOB ras homolog family member B
RPP38 ribonuclease P/MRP 38kDa subunit
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SOX9 SRY (sex determining region Y)-box 9
TBX3 T-box 3
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
VCAN versican
ZFP36L2 ZFP36 ring finger protein-like 2