BRD-K19220233_JNK-9L_LNCAP_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

273 genes differentially expressed following the BRD-K19220233_JNK-9L_LNCAP_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANKRD36B ankyrin repeat domain 36B
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AQP9 aquaporin 9
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
BGN biglycan
BSG basigin (Ok blood group)
C5AR1 complement component 5a receptor 1
CA2 carbonic anhydrase II
CCL4 chemokine (C-C motif) ligand 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CECR1 cat eye syndrome chromosome region, candidate 1
CETN2 centrin, EF-hand protein, 2
CLEC4A C-type lectin domain family 4, member A
CLEC7A C-type lectin domain family 7, member A
COCH cochlin
COL18A1 collagen, type XVIII, alpha 1
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CTSB cathepsin B
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYBRD1 cytochrome b reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCAF10 DDB1 and CUL4 associated factor 10
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
DMXL2 Dmx-like 2
DPYSL3 dihydropyrimidinase-like 3
DST dystonin
ECM1 extracellular matrix protein 1
ENO2 enolase 2 (gamma, neuronal)
ENSA endosulfine alpha
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAXDC2 fatty acid hydroxylase domain containing 2
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GDE1 glycerophosphodiester phosphodiesterase 1
GDF15 growth differentiation factor 15
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GRB14 growth factor receptor-bound protein 14
GSTP1 glutathione S-transferase pi 1
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
HBB hemoglobin, beta
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-G major histocompatibility complex, class I, G
HMGN5 high mobility group nucleosome binding domain 5
HP haptoglobin
HRSP12 heat-responsive protein 12
IFI30 interferon, gamma-inducible protein 30
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
ITM2A integral membrane protein 2A
KIAA0226L KIAA0226-like
LGALS1 lectin, galactoside-binding, soluble, 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100272216 uncharacterized LOC100272216
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LTA4H leukotriene A4 hydrolase
LYN LYN proto-oncogene, Src family tyrosine kinase
LYPD1 LY6/PLAUR domain containing 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MLF2 myeloid leukemia factor 2
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MPP1 membrane protein, palmitoylated 1, 55kDa
MSN moesin
MXRA7 matrix-remodelling associated 7
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NELL2 NEL-like 2 (chicken)
NPC2 Niemann-Pick disease, type C2
NPIPB3 nuclear pore complex interacting protein family, member B3
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUCB1 nucleobindin 1
ORAI2 ORAI calcium release-activated calcium modulator 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAM peptidylglycine alpha-amidating monooxygenase
PCBP2 poly(rC) binding protein 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAGL1 pleiomorphic adenoma gene-like 1
PLBD1 phospholipase B domain containing 1
PLTP phospholipid transfer protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRD protein tyrosine phosphatase, receptor type, D
QPCT glutaminyl-peptide cyclotransferase
RAP2C RAP2C, member of RAS oncogene family
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
S100A11 S100 calcium binding protein A11
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STC1 stanniocalcin 1
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
THY1 Thy-1 cell surface antigen
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TPGS2 tubulin polyglutamylase complex subunit 2
TPM4 tropomyosin 4
TPP1 tripeptidyl peptidase I
TREM1 triggering receptor expressed on myeloid cells 1
TSTA3 tissue specific transplantation antigen P35B
TTC3 tetratricopeptide repeat domain 3
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WFDC2 WAP four-disulfide core domain 2
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADGRG6 adhesion G protein-coupled receptor G6
ADRB2 adrenoceptor beta 2, surface
AKAP1 A kinase (PRKA) anchor protein 1
ALCAM activated leukocyte cell adhesion molecule
AMD1 adenosylmethionine decarboxylase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
B3GNT1
BAG3 BCL2-associated athanogene 3
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BTBD3 BTB (POZ) domain containing 3
C1ORF116 chromosome 1 open reading frame 116
CANT1 calcium activated nucleotidase 1
CASP8AP2 caspase 8 associated protein 2
CCNA2 cyclin A2
CCNB2 cyclin B2
CD164 CD164 molecule, sialomucin
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDKN2AIP CDKN2A interacting protein
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHMP7 charged multivesicular body protein 7
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CRNKL1 crooked neck pre-mRNA splicing factor 1
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPH2 DPH2 homolog (S. cerevisiae)
DUSP5 dual specificity phosphatase 5
DUSP7 dual specificity phosphatase 7
ERBB2 erb-b2 receptor tyrosine kinase 2
FAM57A family with sequence similarity 57, member A
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
FOXO3 forkhead box O3
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GEMIN4 gem (nuclear organelle) associated protein 4
H2AFX H2A histone family, member X
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INHBB inhibin, beta B
ITGA6 integrin, alpha 6
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KEAP1 kelch-like ECH-associated protein 1
KRT7 keratin 7, type II
LIMCH1 LIM and calponin homology domains 1
LXN latexin
MAK16 MAK16 homolog (S. cerevisiae)
MAT2A methionine adenosyltransferase II, alpha
MB myoglobin
MCM10 minichromosome maintenance complex component 10
MED1 mediator complex subunit 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MGP matrix Gla protein
MRPS12 mitochondrial ribosomal protein S12
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDC80 NDC80 kinetochore complex component
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NOL11 nucleolar protein 11
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NRN1 neuritin 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
PCNA proliferating cell nuclear antigen
PIGC phosphatidylinositol glycan anchor biosynthesis, class C
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PIP prolactin-induced protein
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLAC8 placenta-specific 8
PNN pinin, desmosome associated protein
PNP purine nucleoside phosphorylase
PRPF4B pre-mRNA processing factor 4B
PTRH2 peptidyl-tRNA hydrolase 2
RAB14 RAB14, member RAS oncogene family
RNMT RNA (guanine-7-) methyltransferase
RNPS1 RNA binding protein S1, serine-rich domain
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SEH1L SEH1-like (S. cerevisiae)
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC2 transforming, acidic coiled-coil containing protein 2
TFAM transcription factor A, mitochondrial
TFB2M transcription factor B2, mitochondrial
TMEM70 transmembrane protein 70
TMEM97 transmembrane protein 97
TOB1 transducer of ERBB2, 1
TOB2 transducer of ERBB2, 2
TSC22D1 TSC22 domain family, member 1
TXLNA taxilin alpha
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE2C ubiquitin-conjugating enzyme E2C
USP1 ubiquitin specific peptidase 1
VGLL4 vestigial-like family member 4
XBP1 X-box binding protein 1
ZDHHC6 zinc finger, DHHC-type containing 6
ZHX2 zinc fingers and homeoboxes 2