BRD-K19220233_JNK-9L_LNCAP_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

207 genes differentially expressed following the BRD-K19220233_JNK-9L_LNCAP_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADD3 adducin 3 (gamma)
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANKRD36B ankyrin repeat domain 36B
ANXA1 annexin A1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AQP1 aquaporin 1 (Colton blood group)
C5AR1 complement component 5a receptor 1
CADM1 cell adhesion molecule 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLC Charcot-Leyden crystal galectin
CLU clusterin
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CPB1 carboxypeptidase B1 (tissue)
CSTA cystatin A (stefin A)
CTTN cortactin
CYBA cytochrome b-245, alpha polypeptide
CYBRD1 cytochrome b reductase 1
CYFIP2 cytoplasmic FMR1 interacting protein 2
EIF5A eukaryotic translation initiation factor 5A
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FGFR3 fibroblast growth factor receptor 3
FOSB FBJ murine osteosarcoma viral oncogene homolog B
G0S2 G0/G1 switch 2
GOLGA8B golgin A8 family, member B
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H1C histone cluster 1, H1c
HMGN5 high mobility group nucleosome binding domain 5
HRSP12 heat-responsive protein 12
IFI30 interferon, gamma-inducible protein 30
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP7 insulin-like growth factor binding protein 7
ITM2A integral membrane protein 2A
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KIAA0226L KIAA0226-like
KRT19 keratin 19, type I
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00342 long intergenic non-protein coding RNA 342
LOC100272216 uncharacterized LOC100272216
LTA4H leukotriene A4 hydrolase
LYN LYN proto-oncogene, Src family tyrosine kinase
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MXRA7 matrix-remodelling associated 7
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NPC2 Niemann-Pick disease, type C2
NPIPB3 nuclear pore complex interacting protein family, member B3
NQO2 NAD(P)H dehydrogenase, quinone 2
NTS neurotensin
OSBPL10 oxysterol binding protein-like 10
PBLD phenazine biosynthesis-like protein domain containing
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PFKM phosphofructokinase, muscle
PLAU plasminogen activator, urokinase
PLBD1 phospholipase B domain containing 1
PLVAP plasmalemma vesicle associated protein
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAB31 RAB31, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
S100A10 S100 calcium binding protein A10
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPRED2 sprouty-related, EVH1 domain containing 2
STC1 stanniocalcin 1
STK26 serine/threonine protein kinase 26
TCL1A T-cell leukemia/lymphoma 1A
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP3 TIMP metallopeptidase inhibitor 3
TMBIM6 transmembrane BAX inhibitor motif containing 6
TRA2A transformer 2 alpha homolog (Drosophila)
TRIB2 tribbles pseudokinase 2
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

decreased expression

Symbol Name
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACSL3 acyl-CoA synthetase long-chain family member 3
AKAP1 A kinase (PRKA) anchor protein 1
ASS1 argininosuccinate synthase 1
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
BAG3 BCL2-associated athanogene 3
BTBD3 BTB (POZ) domain containing 3
C1ORF116 chromosome 1 open reading frame 116
CANT1 calcium activated nucleotidase 1
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDCA4 cell division cycle associated 4
CHMP7 charged multivesicular body protein 7
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CHTOP chromatin target of PRMT1
CRNKL1 crooked neck pre-mRNA splicing factor 1
CXCL14 chemokine (C-X-C motif) ligand 14
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDIT4 DNA-damage-inducible transcript 4
DEPDC1 DEP domain containing 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPH2 DPH2 homolog (S. cerevisiae)
DUSP7 dual specificity phosphatase 7
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ERBB2 erb-b2 receptor tyrosine kinase 2
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
FOXO3 forkhead box O3
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
H2AFX H2A histone family, member X
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGHM immunoglobulin heavy constant mu
ILF3 interleukin enhancer binding factor 3, 90kDa
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INHBB inhibin, beta B
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT15 keratin 15, type I
LIMCH1 LIM and calponin homology domains 1
MAK16 MAK16 homolog (S. cerevisiae)
MAPK6 mitogen-activated protein kinase 6
MAT2A methionine adenosyltransferase II, alpha
MED1 mediator complex subunit 1
MED17 mediator complex subunit 17
MKL2 MKL/myocardin-like 2
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NGDN neuroguidin, EIF4E binding protein
NOL11 nucleolar protein 11
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PCNA proliferating cell nuclear antigen
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PNP purine nucleoside phosphorylase
PRPF4 pre-mRNA processing factor 4
PRPF4B pre-mRNA processing factor 4B
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
RAB14 RAB14, member RAS oncogene family
RAE1 ribonucleic acid export 1
RFK riboflavin kinase
RNMT RNA (guanine-7-) methyltransferase
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SCAND1 SCAN domain containing 1
SCEL sciellin
SDC1 syndecan 1
SEH1L SEH1-like (S. cerevisiae)
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC2 transforming, acidic coiled-coil containing protein 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFB2M transcription factor B2, mitochondrial
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast)
TMPO thymopoietin
TOB1 transducer of ERBB2, 1
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WDR82 WD repeat domain 82
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZFP36L2 ZFP36 ring finger protein-like 2