BRD-K19220233_JNK-9L_LNCAP_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

90 genes differentially expressed following the BRD-K19220233_JNK-9L_LNCAP_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALOX5 arachidonate 5-lipoxygenase
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
C6ORF62 chromosome 6 open reading frame 62
CCL4 chemokine (C-C motif) ligand 4
CCND2 cyclin D2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES1 carboxylesterase 1
CFLAR CASP8 and FADD-like apoptosis regulator
CPB1 carboxypeptidase B1 (tissue)
CTGF connective tissue growth factor
CTSB cathepsin B
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
EMP3 epithelial membrane protein 3
ENO2 enolase 2 (gamma, neuronal)
EPCAM epithelial cell adhesion molecule
FAM63A family with sequence similarity 63, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FOLR1 folate receptor 1 (adult)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
HMOX1 heme oxygenase 1
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IRS1 insulin receptor substrate 1
LGALS8 lectin, galactoside-binding, soluble, 8
LY86 lymphocyte antigen 86
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDK midkine (neurite growth-promoting factor 2)
MMP1 matrix metallopeptidase 1
MSLN mesothelin
NCAM1 neural cell adhesion molecule 1
PDGFC platelet derived growth factor C
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAP2C RAP2C, member of RAS oncogene family
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RSL1D1 ribosomal L1 domain containing 1
RUNX3 runt-related transcription factor 3
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SMAD7 SMAD family member 7
SPP1 secreted phosphoprotein 1
TPP1 tripeptidyl peptidase I
TRIM22 tripartite motif containing 22
WAC WW domain containing adaptor with coiled-coil
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3
ZNF264 zinc finger protein 264

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
CCNA2 cyclin A2
CCND1 cyclin D1
CD36 CD36 molecule (thrombospondin receptor)
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CKAP4 cytoskeleton-associated protein 4
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
HMG20B high mobility group 20B
HN1 hematological and neurological expressed 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
LIMCH1 LIM and calponin homology domains 1
MRPS16 mitochondrial ribosomal protein S16
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PIP prolactin-induced protein
PNP purine nucleoside phosphorylase
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RPL39L ribosomal protein L39-like
TFRC transferrin receptor
TMEM97 transmembrane protein 97
TP53 tumor protein p53
TSPO translocator protein (18kDa)
TYRP1 tyrosinase-related protein 1
UBE3C ubiquitin protein ligase E3C