BRD-K19220233_JNK-9L_HS578T_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

266 genes differentially expressed following the BRD-K19220233_JNK-9L_HS578T_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
ADIRF adipogenesis regulatory factor
AIF1 allograft inflammatory factor 1
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALOX5 arachidonate 5-lipoxygenase
ANGPTL2 angiopoietin-like 2
ANKRD10 ankyrin repeat domain 10
ANO1 anoctamin 1, calcium activated chloride channel
AQP1 aquaporin 1 (Colton blood group)
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPN asporin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BID BH3 interacting domain death agonist
BRD4 bromodomain containing 4
C5AR1 complement component 5a receptor 1
CALB1 calbindin 1, 28kDa
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CD4 CD4 molecule
CD84 CD84 molecule
CD9 CD9 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CFI complement factor I
CHN1 chimerin 1
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLEC7A C-type lectin domain family 7, member A
CLIC5 chloride intracellular channel 5
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
CPVL carboxypeptidase, vitellogenic-like
CTGF connective tissue growth factor
CTSO cathepsin O
CTSV cathepsin V
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYBB cytochrome b-245, beta polypeptide
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DEFA4 defensin, alpha 4, corticostatin
DENND1B DENN/MADD domain containing 1B
DIO1 deiodinase, iodothyronine, type I
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EFHC2 EF-hand domain (C-terminal) containing 2
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
F11R F11 receptor
F13A1 coagulation factor XIII, A1 polypeptide
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM171A1 family with sequence similarity 171, member A1
FBP1 fructose-1,6-bisphosphatase 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRY furry homolog (Drosophila)
FZD5 frizzled class receptor 5
GAGE3 G antigen 3
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GAS6 growth arrest-specific 6
GEM GTP binding protein overexpressed in skeletal muscle
GLIPR1 GLI pathogenesis-related 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GRB14 growth factor receptor-bound protein 14
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GUK1 guanylate kinase 1
HBE1 hemoglobin, epsilon 1
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HLA-DMA major histocompatibility complex, class II, DM alpha
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOXD1 homeobox D1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA2 heat shock 70kDa protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IL13RA2 interleukin 13 receptor, alpha 2
IL2RG interleukin 2 receptor, gamma
IL7R interleukin 7 receptor
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2C integral membrane protein 2C
KIF5C kinesin family member 5C
KLK10 kallikrein-related peptidase 10
KNG1 kininogen 1
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT19 keratin 19, type I
KRT8 keratin 8, type II
LAMP3 lysosomal-associated membrane protein 3
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MFAP3L microfibrillar-associated protein 3-like
MFAP5 microfibrillar associated protein 5
MUC16 mucin 16, cell surface associated
NCF2 neutrophil cytosolic factor 2
NID1 nidogen 1
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NMU neuromedin U
NOS3 nitric oxide synthase 3 (endothelial cell)
NOX4 NADPH oxidase 4
NR4A2 nuclear receptor subfamily 4, group A, member 2
NXF3 nuclear RNA export factor 3
PBLD phenazine biosynthesis-like protein domain containing
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCLO piccolo presynaptic cytomatrix protein
PDZD2 PDZ domain containing 2
PERP PERP, TP53 apoptosis effector
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLBD1 phospholipase B domain containing 1
PLLP plasmolipin
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PRKCI protein kinase C, iota
PRKCQ protein kinase C, theta
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB25 RAB25, member RAS oncogene family
RABGAP1L RAB GTPase activating protein 1-like
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RGCC regulator of cell cycle
RNASET2 ribonuclease T2
RPL31 ribosomal protein L31
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SH3YL1 SH3 and SYLF domain containing 1
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOD2 superoxide dismutase 2, mitochondrial
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX17 SRY (sex determining region Y)-box 17
SPON1 spondin 1, extracellular matrix protein
STAP2 signal transducing adaptor family member 2
STEAP1 six transmembrane epithelial antigen of the prostate 1
STXBP2 syntaxin binding protein 2
SYNGR2 synaptogyrin 2
TCTN1 tectonic family member 1
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TGFB1 transforming growth factor, beta 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TUSC3 tumor suppressor candidate 3
TWIST1 twist family bHLH transcription factor 1
TYROBP TYRO protein tyrosine kinase binding protein
UGT8 UDP glycosyltransferase 8
VAV3 vav 3 guanine nucleotide exchange factor
VNN1 vanin 1
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
ZFPM2 zinc finger protein, FOG family member 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADGRG2 adhesion G protein-coupled receptor G2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ATG3 autophagy related 3
BASP1 brain abundant, membrane attached signal protein 1
BLMH bleomycin hydrolase
BLVRA biliverdin reductase A
BTG1 B-cell translocation gene 1, anti-proliferative
C16ORF45 chromosome 16 open reading frame 45
CALML3 calmodulin-like 3
CALML5 calmodulin-like 5
CCNB2 cyclin B2
CD24 CD24 molecule
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTBP2 C-terminal binding protein 2
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FBL fibrillarin
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD7 frizzled class receptor 7
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GLOD4 glyoxalase domain containing 4
GRB10 growth factor receptor-bound protein 10
GSTA4 glutathione S-transferase alpha 4
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPM heterogeneous nuclear ribonucleoprotein M
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KDM5D lysine (K)-specific demethylase 5D
KRT15 keratin 15, type I
KRT81 keratin 81, type II
LASP1 LIM and SH3 protein 1
LRP4 low density lipoprotein receptor-related protein 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MET MET proto-oncogene, receptor tyrosine kinase
MYBPC1 myosin binding protein C, slow type
MYO10 myosin X
NR2F2 nuclear receptor subfamily 2, group F, member 2
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PCM1 pericentriolar material 1
PCNA proliferating cell nuclear antigen
PEX11A peroxisomal biogenesis factor 11 alpha
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
POU2AF1 POU class 2 associating factor 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PWP1 PWP1 homolog (S. cerevisiae)
RABGAP1 RAB GTPase activating protein 1
RALB v-ral simian leukemia viral oncogene homolog B
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
SCAND1 SCAN domain containing 1
SMC4 structural maintenance of chromosomes 4
SOAT1 sterol O-acyltransferase 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRSF1 serine/arginine-rich splicing factor 1
SRSF3 serine/arginine-rich splicing factor 3
TBL1X transducin (beta)-like 1X-linked
TCF12 transcription factor 12
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TUBB tubulin, beta class I
WDR1 WD repeat domain 1
WSB1 WD repeat and SOCS box containing 1
YBX3 Y box binding protein 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon