BRD-K19220233_JNK-9L_HS578T_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

287 genes differentially expressed following the BRD-K19220233_JNK-9L_HS578T_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
ADIRF adipogenesis regulatory factor
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANGPTL2 angiopoietin-like 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
ANO1 anoctamin 1, calcium activated chloride channel
ANXA11 annexin A11
AOC3 amine oxidase, copper containing 3
AOX1 aldehyde oxidase 1
AQP1 aquaporin 1 (Colton blood group)
AQP9 aquaporin 9
AREG amphiregulin
ASPN asporin
ATF3 activating transcription factor 3
ATP10B ATPase, class V, type 10B
BIK BCL2-interacting killer (apoptosis-inducing)
BLNK B-cell linker
C1R complement component 1, r subcomponent
C7 complement component 7
C9ORF16 chromosome 9 open reading frame 16
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CD46 CD46 molecule, complement regulatory protein
CD84 CD84 molecule
CD9 CD9 molecule
CERS6 ceramide synthase 6
CFB complement factor B
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CKB creatine kinase, brain
CLEC4A C-type lectin domain family 4, member A
CLEC7A C-type lectin domain family 7, member A
CLIC2 chloride intracellular channel 2
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
CPVL carboxypeptidase, vitellogenic-like
CSRP2 cysteine and glycine-rich protein 2
CTGF connective tissue growth factor
CTSO cathepsin O
CTSV cathepsin V
CTTN cortactin
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DUSP4 dual specificity phosphatase 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFHC2 EF-hand domain (C-terminal) containing 2
EFNB2 ephrin-B2
EGF epidermal growth factor
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EML1 echinoderm microtubule associated protein like 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
F2R coagulation factor II (thrombin) receptor
FABP1 fatty acid binding protein 1, liver
FBLN1 fibulin 1
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FYB FYN binding protein
FZD5 frizzled class receptor 5
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GEM GTP binding protein overexpressed in skeletal muscle
GGCX gamma-glutamyl carboxylase
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNB5 guanine nucleotide binding protein (G protein), beta 5
GPC4 glypican 4
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GRB14 growth factor receptor-bound protein 14
GREM1 gremlin 1, DAN family BMP antagonist
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GUK1 guanylate kinase 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IL13RA2 interleukin 13 receptor, alpha 2
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL7R interleukin 7 receptor
ITGB1BP1 integrin beta 1 binding protein 1
ITM2C integral membrane protein 2C
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIF5C kinesin family member 5C
KNG1 kininogen 1
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT8 keratin 8, type II
LAMP2 lysosomal-associated membrane protein 2
LAMP3 lysosomal-associated membrane protein 3
LGMN legumain
LRRC15 leucine rich repeat containing 15
MCUR1 mitochondrial calcium uniporter regulator 1
MDFIC MyoD family inhibitor domain containing
MDK midkine (neurite growth-promoting factor 2)
MFAP5 microfibrillar associated protein 5
MMP12 matrix metallopeptidase 12
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
MYO5C myosin VC
NCF2 neutrophil cytosolic factor 2
NINJ2 ninjurin 2
NMU neuromedin U
NPTX2 neuronal pentraxin II
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OMD osteomodulin
PBLD phenazine biosynthesis-like protein domain containing
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK6 proprotein convertase subtilisin/kexin type 6
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE9A phosphodiesterase 9A
PECAM1 platelet/endothelial cell adhesion molecule 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLBD1 phospholipase B domain containing 1
PPT1 palmitoyl-protein thioesterase 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCI protein kinase C, iota
PRKCQ protein kinase C, theta
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RNF130 ring finger protein 130
RRAGD Ras-related GTP binding D
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SEPT6 septin 6
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SMYD3 SET and MYND domain containing 3
SOX17 SRY (sex determining region Y)-box 17
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SULF1 sulfatase 1
SYNGR2 synaptogyrin 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM14B transmembrane protein 14B
TMEM231 transmembrane protein 231
TMSB15A thymosin beta 15a
TPD52 tumor protein D52
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TPST2 tyrosylprotein sulfotransferase 2
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TWIST1 twist family bHLH transcription factor 1
TYROBP TYRO protein tyrosine kinase binding protein
VAV3 vav 3 guanine nucleotide exchange factor
VEGFB vascular endothelial growth factor B
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331
ZNF467 zinc finger protein 467

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ADGRG2 adhesion G protein-coupled receptor G2
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
CALML3 calmodulin-like 3
CALML5 calmodulin-like 5
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
DDIT4 DNA-damage-inducible transcript 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
EPS8 epidermal growth factor receptor pathway substrate 8
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GLOD4 glyoxalase domain containing 4
GRB10 growth factor receptor-bound protein 10
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPM heterogeneous nuclear ribonucleoprotein M
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHD immunoglobulin heavy constant delta
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IVNS1ABP influenza virus NS1A binding protein
JUN jun proto-oncogene
KANK1 KN motif and ankyrin repeat domains 1
KDM5D lysine (K)-specific demethylase 5D
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT15 keratin 15, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LASP1 LIM and SH3 protein 1
LBR lamin B receptor
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MYBPC1 myosin binding protein C, slow type
MYO10 myosin X
NEFL neurofilament, light polypeptide
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
PDE4DIP phosphodiesterase 4D interacting protein
PEG10 paternally expressed 10
PEX11A peroxisomal biogenesis factor 11 alpha
PLIN2 perilipin 2
PLK1 polo-like kinase 1
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
POU2AF1 POU class 2 associating factor 1
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PTTG1 pituitary tumor-transforming 1
PTX3 pentraxin 3, long
PWP1 PWP1 homolog (S. cerevisiae)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBBP4 retinoblastoma binding protein 4
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RFTN1 raftlin, lipid raft linker 1
RIN2 Ras and Rab interactor 2
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGA Ras-related GTP binding A
SCAND1 SCAN domain containing 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMAD3 SMAD family member 3
SMC4 structural maintenance of chromosomes 4
SNAP25 synaptosomal-associated protein, 25kDa
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGN serglycin
SRSF1 serine/arginine-rich splicing factor 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOP2A topoisomerase (DNA) II alpha 170kDa
TRA2B transformer 2 beta homolog (Drosophila)
TRAM2 translocation associated membrane protein 2
TRAPPC3 trafficking protein particle complex 3
TSPYL5 TSPY-like 5
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
VCP valosin containing protein
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZIC1 Zic family member 1