BRD-K19220233_JNK-9L_HME1_3_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-K19220233_JNK-9L_HME1_3_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ASRGL1 asparaginase like 1
CBS cystathionine-beta-synthase
CHEK2 checkpoint kinase 2
FHL1 four and a half LIM domains 1
FXYD2 FXYD domain containing ion transport regulator 2
GPX3 glutathione peroxidase 3
GUSBP11 glucuronidase, beta pseudogene 11
HOXC10 homeobox C10
ITM2A integral membrane protein 2A
LEPR leptin receptor
LY6E lymphocyte antigen 6 complex, locus E
NPTX2 neuronal pentraxin II
OXTR oxytocin receptor
PBLD phenazine biosynthesis-like protein domain containing
PLAC8 placenta-specific 8
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PROM1 prominin 1
SCN3A sodium channel, voltage gated, type III alpha subunit
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
TPD52L1 tumor protein D52-like 1
TRPS1 trichorhinophalangeal syndrome I
TSC22D3 TSC22 domain family, member 3
TWIST1 twist family bHLH transcription factor 1

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADRB2 adrenoceptor beta 2, surface
ATF3 activating transcription factor 3
BIRC3 baculoviral IAP repeat containing 3
BTG2 BTG family, member 2
C8ORF4 chromosome 8 open reading frame 4
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDCA4 cell division cycle associated 4
CST1 cystatin SN
DUSP6 dual specificity phosphatase 6
GADD45B growth arrest and DNA-damage-inducible, beta
HES1 hes family bHLH transcription factor 1
HHEX hematopoietically expressed homeobox
HMOX1 heme oxygenase 1
HP haptoglobin
HSPA1A heat shock 70kDa protein 1A
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IL1RN interleukin 1 receptor antagonist
IL32 interleukin 32
JUN jun proto-oncogene
JUNB jun B proto-oncogene
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NRN1 neuritin 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBM12 RNA binding motif protein 12
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SGK1 serum/glucocorticoid regulated kinase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
TACSTD2 tumor-associated calcium signal transducer 2
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
THBD thrombomodulin
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
WT1 Wilms tumor 1
ZFP36 ZFP36 ring finger protein