BRD-K19220233_JNK-9L_HME1_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

278 genes differentially expressed following the BRD-K19220233_JNK-9L_HME1_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT7 acyl-CoA thioesterase 7
ACP5 acid phosphatase 5, tartrate resistant
ADAMDEC1 ADAM-like, decysin 1
ADCY7 adenylate cyclase 7
ADD3 adducin 3 (gamma)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ANO1 anoctamin 1, calcium activated chloride channel
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ATF3 activating transcription factor 3
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
BHLHE40 basic helix-loop-helix family, member e40
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BSG basigin (Ok blood group)
C9ORF16 chromosome 9 open reading frame 16
CADM1 cell adhesion molecule 1
CALB1 calbindin 1, 28kDa
CAPG capping protein (actin filament), gelsolin-like
CCL20 chemokine (C-C motif) ligand 20
CCL8 chemokine (C-C motif) ligand 8
CD4 CD4 molecule
CD84 CD84 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CKB creatine kinase, brain
CLDN3 claudin 3
CLEC11A C-type lectin domain family 11, member A
CLEC7A C-type lectin domain family 7, member A
CLU clusterin
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
CPE carboxypeptidase E
CTSB cathepsin B
CTSO cathepsin O
CTSS cathepsin S
CTSZ cathepsin Z
CTTN cortactin
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
DMXL2 Dmx-like 2
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FECH ferrochelatase
FIBP fibroblast growth factor (acidic) intracellular binding protein
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
GATAD1 GATA zinc finger domain containing 1
GDE1 glycerophosphodiester phosphodiesterase 1
GLB1L2 galactosidase, beta 1-like 2
GM2A GM2 ganglioside activator
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGN5 high mobility group nucleosome binding domain 5
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
HSDL2 hydroxysteroid dehydrogenase like 2
ICAM1 intercellular adhesion molecule 1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IRF1 interferon regulatory factor 1
ISG15 ISG15 ubiquitin-like modifier
ITFG1 integrin alpha FG-GAP repeat containing 1
ITM2A integral membrane protein 2A
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JUNB jun B proto-oncogene
KAT2B K(lysine) acetyltransferase 2B
KNG1 kininogen 1
LDHB lactate dehydrogenase B
LEF1 lymphoid enhancer-binding factor 1
LEFTY1 left-right determination factor 1
LETMD1 LETM1 domain containing 1
LTA4H leukotriene A4 hydrolase
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN2B2 mannosidase, alpha, class 2B, member 2
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
METTL7A methyltransferase like 7A
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MPP1 membrane protein, palmitoylated 1, 55kDa
MXI1 MAX interactor 1, dimerization protein
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
OVGP1 oviductal glycoprotein 1, 120kDa
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PARM1 prostate androgen-regulated mucin-like protein 1
PAWR PRKC, apoptosis, WT1, regulator
PCBP2 poly(rC) binding protein 2
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEBP1 phosphatidylethanolamine binding protein 1
PLBD1 phospholipase B domain containing 1
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPT1 palmitoyl-protein thioesterase 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRD protein tyrosine phosphatase, receptor type, D
QPRT quinolinate phosphoribosyltransferase
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB31 RAB31, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBP1 retinol binding protein 1, cellular
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RHOBTB3 Rho-related BTB domain containing 3
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
RRAGD Ras-related GTP binding D
RTN3 reticulon 3
S100A4 S100 calcium binding protein A4
SATB1 SATB homeobox 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELL selectin L
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC35F2 solute carrier family 35, member F2
SNX10 sorting nexin 10
SOD2 superoxide dismutase 2, mitochondrial
SORD sorbitol dehydrogenase
STC1 stanniocalcin 1
SYT1 synaptotagmin I
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THY1 Thy-1 cell surface antigen
TLR4 toll-like receptor 4
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TPD52 tumor protein D52
TRBC1 T cell receptor beta constant 1
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA8 von Willebrand factor A domain containing 8
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
AHR aryl hydrocarbon receptor
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARMCX6 armadillo repeat containing, X-linked 6
ATMIN ATM interactor
AURKA aurora kinase A
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BLCAP bladder cancer associated protein
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPA centromere protein A
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CXCL14 chemokine (C-X-C motif) ligand 14
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP6 dual specificity phosphatase 6
EAPP E2F-associated phosphoprotein
ETV5 ets variant 5
FEN1 flap structure-specific endonuclease 1
FOXO3 forkhead box O3
GAS1 growth arrest-specific 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFI16 interferon, gamma-inducible protein 16
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KDM3A lysine (K)-specific demethylase 3A
KEAP1 kelch-like ECH-associated protein 1
KIF20A kinesin family member 20A
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT7 keratin 7, type II
LBR lamin B receptor
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAPK6 mitogen-activated protein kinase 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MCM3 minichromosome maintenance complex component 3
MRPL15 mitochondrial ribosomal protein L15
MRPS12 mitochondrial ribosomal protein S12
NDEL1 nudE neurodevelopment protein 1-like 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIB nuclear factor I/B
NNMT nicotinamide N-methyltransferase
NOL11 nucleolar protein 11
NOP56 NOP56 ribonucleoprotein
NUP62 nucleoporin 62kDa
PCNA proliferating cell nuclear antigen
PDCD10 programmed cell death 10
PDGFA platelet-derived growth factor alpha polypeptide
PELO pelota homolog (Drosophila)
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
POU2AF1 POU class 2 associating factor 1
PRPF4B pre-mRNA processing factor 4B
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
PUM1 pumilio RNA-binding family member 1
PXDN peroxidasin
RAE1 ribonucleic acid export 1
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACC2 transforming, acidic coiled-coil containing protein 2
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMPO thymopoietin
TRAM2 translocation associated membrane protein 2
TRAPPC3 trafficking protein particle complex 3
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM29 tripartite motif containing 29
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
UMPS uridine monophosphate synthetase
VCAN versican
VCP valosin containing protein
XBP1 X-box binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2