BRD-K19220233_JNK-9L_HME1_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

230 genes differentially expressed following the BRD-K19220233_JNK-9L_HME1_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACP5 acid phosphatase 5, tartrate resistant
ADCY7 adenylate cyclase 7
ADD3 adducin 3 (gamma)
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKRD36B ankyrin repeat domain 36B
ANO1 anoctamin 1, calcium activated chloride channel
ASPN asporin
ATP10B ATPase, class V, type 10B
ATP2B2 ATPase, Ca++ transporting, plasma membrane 2
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AZU1 azurocidin 1
BHLHE40 basic helix-loop-helix family, member e40
BSG basigin (Ok blood group)
C9ORF16 chromosome 9 open reading frame 16
CADM1 cell adhesion molecule 1
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD302 CD302 molecule
CD84 CD84 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CERS6 ceramide synthase 6
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKB creatine kinase, brain
CLEC7A C-type lectin domain family 7, member A
CTSB cathepsin B
CTSS cathepsin S
CTSZ cathepsin Z
CTTN cortactin
CXCL8 chemokine (C-X-C motif) ligand 8
CYB561 cytochrome b561
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DIRAS3 DIRAS family, GTP-binding RAS-like 3
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FABP1 fatty acid binding protein 1, liver
FGFR1 fibroblast growth factor receptor 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FTH1 ferritin, heavy polypeptide 1
GAP43 growth associated protein 43
GOLGA8B golgin A8 family, member B
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
GSTM3 glutathione S-transferase mu 3 (brain)
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP3 glucuronidase, beta pseudogene 3
HAPLN1 hyaluronan and proteoglycan link protein 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
IER3 immediate early response 3
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IL13RA2 interleukin 13 receptor, alpha 2
ITFG1 integrin alpha FG-GAP repeat containing 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCMF1 potassium channel modulatory factor 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LEF1 lymphoid enhancer-binding factor 1
LEFTY1 left-right determination factor 1
LTBP1 latent transforming growth factor beta binding protein 1
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
MXI1 MAX interactor 1, dimerization protein
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OPHN1 oligophrenin 1
OVGP1 oviductal glycoprotein 1, 120kDa
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PARM1 prostate androgen-regulated mucin-like protein 1
PCBP2 poly(rC) binding protein 2
PLBD1 phospholipase B domain containing 1
PODXL podocalyxin-like
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPT1 palmitoyl-protein thioesterase 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSIP1 PC4 and SFRS1 interacting protein 1
PSPH phosphoserine phosphatase
PTN pleiotrophin
PTPRD protein tyrosine phosphatase, receptor type, D
PTPRO protein tyrosine phosphatase, receptor type, O
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RABGAP1L RAB GTPase activating protein 1-like
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP1 retinol binding protein 1, cellular
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RPL31 ribosomal protein L31
RRAGD Ras-related GTP binding D
SCD5 stearoyl-CoA desaturase 5
SCG5 secretogranin V
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC5 serine incorporator 5
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SH2D1A SH2 domain containing 1A
SNX10 sorting nexin 10
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
STC1 stanniocalcin 1
STK38L serine/threonine kinase 38 like
STMN2 stathmin 2
SUSD4 sushi domain containing 4
SV2A synaptic vesicle glycoprotein 2A
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TPD52 tumor protein D52
TPMT thiopurine S-methyltransferase
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
VAT1 vesicle amine transport 1
VNN1 vanin 1
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZIC1 Zic family member 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ADRB2 adrenoceptor beta 2, surface
AHNAK2 AHNAK nucleoprotein 2
AHR aryl hydrocarbon receptor
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AQP3 aquaporin 3 (Gill blood group)
AURKA aurora kinase A
BAG3 BCL2-associated athanogene 3
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CENPA centromere protein A
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
EAPP E2F-associated phosphoprotein
EIF6 eukaryotic translation initiation factor 6
ETV5 ets variant 5
FEN1 flap structure-specific endonuclease 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI16 interferon, gamma-inducible protein 16
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
KAT6A K(lysine) acetyltransferase 6A
KIF20A kinesin family member 20A
KLK5 kallikrein-related peptidase 5
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT7 keratin 7, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBR lamin B receptor
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MRPS12 mitochondrial ribosomal protein S12
NDC80 NDC80 kinetochore complex component
NFIL3 nuclear factor, interleukin 3 regulated
NGDN neuroguidin, EIF4E binding protein
NNMT nicotinamide N-methyltransferase
NOL11 nucleolar protein 11
NOP16 NOP16 nucleolar protein
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NXN nucleoredoxin
PCNA proliferating cell nuclear antigen
PDGFA platelet-derived growth factor alpha polypeptide
PELO pelota homolog (Drosophila)
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
PTX3 pentraxin 3, long
PUF60 poly-U binding splicing factor 60KDa
PXDN peroxidasin
RAE1 ribonucleic acid export 1
RIN2 Ras and Rab interactor 2
RPS4Y1 ribosomal protein S4, Y-linked 1
S100P S100 calcium binding protein P
SCML1 sex comb on midleg-like 1 (Drosophila)
SFN stratifin
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC38A2 solute carrier family 38, member 2
SMAD3 SMAD family member 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC2 transforming, acidic coiled-coil containing protein 2
TACSTD2 tumor-associated calcium signal transducer 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMPO thymopoietin
TRAM2 translocation associated membrane protein 2
TRIAP1 TP53 regulated inhibitor of apoptosis 1
TRIM29 tripartite motif containing 29
TSPYL5 TSPY-like 5
TUBA4A tubulin, alpha 4a
TXLNA taxilin alpha
USP1 ubiquitin specific peptidase 1
WEE1 WEE1 G2 checkpoint kinase
ZBTB16 zinc finger and BTB domain containing 16