BRD-K19220233_JNK-9L_HME1_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

216 genes differentially expressed following the BRD-K19220233_JNK-9L_HME1_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACKR3 atypical chemokine receptor 3
ACLY ATP citrate lyase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDOC aldolase C, fructose-bisphosphate
APOC2 apolipoprotein C-II
AQP1 aquaporin 1 (Colton blood group)
AZIN1 antizyme inhibitor 1
BHLHE41 basic helix-loop-helix family, member e41
BHMT2 betaine--homocysteine S-methyltransferase 2
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
C1ORF106 chromosome 1 open reading frame 106
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
CALB1 calbindin 1, 28kDa
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CD86 CD86 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CECR1 cat eye syndrome chromosome region, candidate 1
CFD complement factor D (adipsin)
CHERP calcium homeostasis endoplasmic reticulum protein
CLEC7A C-type lectin domain family 7, member A
CPE carboxypeptidase E
CPVL carboxypeptidase, vitellogenic-like
CRABP1 cellular retinoic acid binding protein 1
CRISP3 cysteine-rich secretory protein 3
CRYAB crystallin, alpha B
CTSS cathepsin S
CTTN cortactin
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1
DACH1 dachshund family transcription factor 1
DENND1A DENN/MADD domain containing 1A
DIO1 deiodinase, iodothyronine, type I
DLX2 distal-less homeobox 2
ELF4 E74-like factor 4 (ets domain transcription factor)
EPHA3 EPH receptor A3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FRZB frizzled-related protein
GADD45B growth arrest and DNA-damage-inducible, beta
GCLC glutamate-cysteine ligase, catalytic subunit
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GGT1 gamma-glutamyltransferase 1
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPR183 G protein-coupled receptor 183
GPX3 glutathione peroxidase 3
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IL32 interleukin 32
ITM2A integral membrane protein 2A
JAG1 jagged 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KYNU kynureninase
LAMP1 lysosomal-associated membrane protein 1
LOC283683 uncharacterized LOC283683
LY86 lymphocyte antigen 86
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MCTP1 multiple C2 domains, transmembrane 1
MEF2C myocyte enhancer factor 2C
MICB MHC class I polypeptide-related sequence B
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
NEFL neurofilament, light polypeptide
NME5 NME/NM23 family member 5
NRCAM neuronal cell adhesion molecule
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
PCDH7 protocadherin 7
PFN2 profilin 2
PLTP phospholipid transfer protein
PTCH1 patched 1
PTN pleiotrophin
PTPRD protein tyrosine phosphatase, receptor type, D
RAB20 RAB20, member RAS oncogene family
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBP1 retinol binding protein 1, cellular
REG1A regenerating islet-derived 1 alpha
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
RNMT RNA (guanine-7-) methyltransferase
RPL31 ribosomal protein L31
RRAGD Ras-related GTP binding D
RSAD2 radical S-adenosyl methionine domain containing 2
RSL1D1 ribosomal L1 domain containing 1
S100A7 S100 calcium binding protein A7
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDS serine dehydratase
SELL selectin L
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNX10 sorting nexin 10
SOD2 superoxide dismutase 2, mitochondrial
ST18 suppression of tumorigenicity 18, zinc finger
STMN2 stathmin 2
TAC1 tachykinin, precursor 1
TACC1 transforming, acidic coiled-coil containing protein 1
TFF3 trefoil factor 3 (intestinal)
TICAM1 toll-like receptor adaptor molecule 1
TMEM45A transmembrane protein 45A
TPD52 tumor protein D52
TPO thyroid peroxidase
TSPAN7 tetraspanin 7
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAT1 vesicle amine transport 1
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WT1 Wilms tumor 1
XIST X inactive specific transcript (non-protein coding)
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZEB2 zinc finger E-box binding homeobox 2
ZNF264 zinc finger protein 264
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
AARS alanyl-tRNA synthetase
ADRB2 adrenoceptor beta 2, surface
AGTR1 angiotensin II receptor, type 1
ALCAM activated leukocyte cell adhesion molecule
AQP3 aquaporin 3 (Gill blood group)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
B3GNT1
BLMH bleomycin hydrolase
C3ORF14 chromosome 3 open reading frame 14
CCNB2 cyclin B2
CD36 CD36 molecule (thrombospondin receptor)
CENPE centromere protein E, 312kDa
CKS2 CDC28 protein kinase regulatory subunit 2
COL1A1 collagen, type I, alpha 1
COL3A1 collagen, type III, alpha 1
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNM1L dynamin 1-like
DPYSL2 dihydropyrimidinase-like 2
EPS8 epidermal growth factor receptor pathway substrate 8
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FSTL1 follistatin-like 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALE UDP-galactose-4-epimerase
GATA3 GATA binding protein 3
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GRB7 growth factor receptor-bound protein 7
H1F0 H1 histone family, member 0
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HOXC6 homeobox C6
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP4 insulin-like growth factor binding protein 4
ITGA6 integrin, alpha 6
KIF1BP KIF1 binding protein
KIF20A kinesin family member 20A
KLHL9 kelch-like family member 9
KRT15 keratin 15, type I
KRT7 keratin 7, type II
LAMC1 laminin, gamma 1 (formerly LAMB2)
LDLR low density lipoprotein receptor
MB myoglobin
MTUS1 microtubule associated tumor suppressor 1
NCAPG non-SMC condensin I complex, subunit G
NMI N-myc (and STAT) interactor
NNMT nicotinamide N-methyltransferase
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NR2F2 nuclear receptor subfamily 2, group F, member 2
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PARP2 poly (ADP-ribose) polymerase 2
PCM1 pericentriolar material 1
PLSCR4 phospholipid scramblase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIE peptidylprolyl isomerase E (cyclophilin E)
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCA protein kinase C, alpha
PXDN peroxidasin
RAD51C RAD51 paralog C
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RFC2 replication factor C (activator 1) 2, 40kDa
RPS11 ribosomal protein S11
SDPR serum deprivation response
SLC38A2 solute carrier family 38, member 2
SMC4 structural maintenance of chromosomes 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TAGLN2 transgelin 2
TBL1X transducin (beta)-like 1X-linked
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
VCAN versican
WNT5A wingless-type MMTV integration site family, member 5A