BRD-K19220233_JNK-9L_HEPG2_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-K19220233_JNK-9L_HEPG2_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ADGRE5 adhesion G protein-coupled receptor E5
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALCAM activated leukocyte cell adhesion molecule
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
APOE apolipoprotein E
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
BBX bobby sox homolog (Drosophila)
BHLHE41 basic helix-loop-helix family, member e41
C6ORF62 chromosome 6 open reading frame 62
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CRTAP cartilage associated protein
CXCL8 chemokine (C-X-C motif) ligand 8
CYBB cytochrome b-245, beta polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DMXL2 Dmx-like 2
ECM1 extracellular matrix protein 1
EFNB2 ephrin-B2
EGR1 early growth response 1
EGR2 early growth response 2
EMP1 epithelial membrane protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
FGF13 fibroblast growth factor 13
FOLR1 folate receptor 1 (adult)
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GAA glucosidase, alpha; acid
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GPNMB glycoprotein (transmembrane) nmb
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSN gelsolin
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL2RG interleukin 2 receptor, gamma
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM5A lysine (K)-specific demethylase 5A
LDHB lactate dehydrogenase B
LEF1 lymphoid enhancer-binding factor 1
LGMN legumain
LY75 lymphocyte antigen 75
MAN2B1 mannosidase, alpha, class 2B, member 1
MAN2B2 mannosidase, alpha, class 2B, member 2
MED13L mediator complex subunit 13-like
MFAP3L microfibrillar-associated protein 3-like
MMP12 matrix metallopeptidase 12
NAP1L3 nucleosome assembly protein 1-like 3
NR1D2 nuclear receptor subfamily 1, group D, member 2
NTS neurotensin
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDIA5 protein disulfide isomerase family A, member 5
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PEBP1 phosphatidylethanolamine binding protein 1
PIGT phosphatidylinositol glycan anchor biosynthesis, class T
PIR pirin (iron-binding nuclear protein)
PLTP phospholipid transfer protein
PNMAL1 paraneoplastic Ma antigen family-like 1
PRAME preferentially expressed antigen in melanoma
PROS1 protein S (alpha)
RCAN1 regulator of calcineurin 1
RPL39L ribosomal protein L39-like
RRAGD Ras-related GTP binding D
SCAMP1 secretory carrier membrane protein 1
SCD5 stearoyl-CoA desaturase 5
SCPEP1 serine carboxypeptidase 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SH3YL1 SH3 and SYLF domain containing 1
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SRRM2 serine/arginine repetitive matrix 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STC1 stanniocalcin 1
STC2 stanniocalcin 2
SYT1 synaptotagmin I
TBX2 T-box 2
THBS1 thrombospondin 1
TPD52 tumor protein D52
TRIB2 tribbles pseudokinase 2
TSPAN31 tetraspanin 31
TUSC3 tumor suppressor candidate 3
TWF1 twinfilin actin binding protein 1
USP33 ubiquitin specific peptidase 33
VIM vimentin
VSIG4 V-set and immunoglobulin domain containing 4
WIF1 WNT inhibitory factor 1
XIST X inactive specific transcript (non-protein coding)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AK1 adenylate kinase 1
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BAD BCL2-associated agonist of cell death
CA2 carbonic anhydrase II
CCL20 chemokine (C-C motif) ligand 20
CCNA2 cyclin A2
CCND1 cyclin D1
CD200 CD200 molecule
CDC20 cell division cycle 20
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CTNND1 catenin (cadherin-associated protein), delta 1
DCK deoxycytidine kinase
EAPP E2F-associated phosphoprotein
ERBB2 erb-b2 receptor tyrosine kinase 2
FCGBP Fc fragment of IgG binding protein
GTPBP8 GTP-binding protein 8 (putative)
GUSBP11 glucuronidase, beta pseudogene 11
H1F0 H1 histone family, member 0
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP4 insulin-like growth factor binding protein 4
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JCHAIN joining chain of multimeric IgA and IgM
KRT19 keratin 19, type I
LBR lamin B receptor
MB myoglobin
MREG melanoregulin
MTUS1 microtubule associated tumor suppressor 1
MYBPC1 myosin binding protein C, slow type
NDC80 NDC80 kinetochore complex component
NFIB nuclear factor I/B
NXN nucleoredoxin
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PCNA proliferating cell nuclear antigen
PDHX pyruvate dehydrogenase complex, component X
PDLIM3 PDZ and LIM domain 3
POU2AF1 POU class 2 associating factor 1
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PTPRK protein tyrosine phosphatase, receptor type, K
S100A7 S100 calcium binding protein A7
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SMCO4 single-pass membrane protein with coiled-coil domains 4
SPTSSA serine palmitoyltransferase, small subunit A
STIP1 stress-induced phosphoprotein 1
SYNM synemin, intermediate filament protein
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM176B transmembrane protein 176B
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TXLNA taxilin alpha
XBP1 X-box binding protein 1
ZHX2 zinc fingers and homeoboxes 2