BRD-K19220233_JNK-9L_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-K19220233_JNK-9L_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADD3 adducin 3 (gamma)
AKR1C2 aldo-keto reductase family 1, member C2
ALCAM activated leukocyte cell adhesion molecule
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AQP9 aquaporin 9
ASCL1 achaete-scute family bHLH transcription factor 1
BASP1 brain abundant, membrane attached signal protein 1
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCR1 chemokine (C-C motif) receptor 1
CD9 CD9 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COG5 component of oligomeric golgi complex 5
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
CTSZ cathepsin Z
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DMXL2 Dmx-like 2
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
EGR2 early growth response 2
EID1 EP300 interacting inhibitor of differentiation 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
FHL1 four and a half LIM domains 1
FPR1 formyl peptide receptor 1
FUCA1 fucosidase, alpha-L- 1, tissue
G0S2 G0/G1 switch 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GM2A GM2 ganglioside activator
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GSTP1 glutathione S-transferase pi 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIP1 huntingtin interacting protein 1
HIST1H1C histone cluster 1, H1c
IFITM1 interferon induced transmembrane protein 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
LAMP1 lysosomal-associated membrane protein 1
LDHB lactate dehydrogenase B
LEF1 lymphoid enhancer-binding factor 1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN2B1 mannosidase, alpha, class 2B, member 1
MPP1 membrane protein, palmitoylated 1, 55kDa
NCF2 neutrophil cytosolic factor 2
NLRP2 NLR family, pyrin domain containing 2
NR1D2 nuclear receptor subfamily 1, group D, member 2
NTS neurotensin
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin
PBLD phenazine biosynthesis-like protein domain containing
PDK4 pyruvate dehydrogenase kinase, isozyme 4
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
PROS1 protein S (alpha)
RCAN1 regulator of calcineurin 1
RRAGD Ras-related GTP binding D
SAP18 Sin3A-associated protein, 18kDa
SEPT8 septin 8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SSBP2 single-stranded DNA binding protein 2
STC1 stanniocalcin 1
SYT1 synaptotagmin I
TENM1 teneurin transmembrane protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFA transforming growth factor, alpha
TLR4 toll-like receptor 4
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMED3 transmembrane emp24 protein transport domain containing 3
TSPAN3 tetraspanin 3
TUSC3 tumor suppressor candidate 3
VIM vimentin

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
ASS1 argininosuccinate synthase 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
C3 complement component 3
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CD200 CD200 molecule
CDC20 cell division cycle 20
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CKS2 CDC28 protein kinase regulatory subunit 2
CTNND1 catenin (cadherin-associated protein), delta 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF5 eukaryotic translation initiation factor 5
FCGBP Fc fragment of IgG binding protein
GJA1 gap junction protein, alpha 1, 43kDa
H2AFX H2A histone family, member X
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HSPA8 heat shock 70kDa protein 8
IFNGR1 interferon gamma receptor 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
IGLJ3 immunoglobulin lambda joining 3
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KIAA0101 KIAA0101
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
KRT23 keratin 23, type I
LCN2 lipocalin 2
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
MED17 mediator complex subunit 17
MRPL12 mitochondrial ribosomal protein L12
MRPS12 mitochondrial ribosomal protein S12
NRIP1 nuclear receptor interacting protein 1
NSG1 neuron specific gene family member 1
NUSAP1 nucleolar and spindle associated protein 1
NXN nucleoredoxin
OSER1 oxidative stress responsive serine-rich 1
PCNA proliferating cell nuclear antigen
PDPN podoplanin
PDZRN3 PDZ domain containing ring finger 3
PEG3 paternally expressed 3
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma
PLAC8 placenta-specific 8
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PNP purine nucleoside phosphorylase
POU2AF1 POU class 2 associating factor 1
PROM1 prominin 1
RAE1 ribonucleic acid export 1
S100A7 S100 calcium binding protein A7
SEC24B SEC24 family member B
SLC38A2 solute carrier family 38, member 2
SLPI secretory leukocyte peptidase inhibitor
SMAD1 SMAD family member 1
STIP1 stress-induced phosphoprotein 1
TBP TATA box binding protein
TCP1 t-complex 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM2 tripartite motif containing 2
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TXLNA taxilin alpha
TYMS thymidylate synthetase
XBP1 X-box binding protein 1