BRD-K19220233_JNK-9L_HCC515_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

298 genes differentially expressed following the BRD-K19220233_JNK-9L_HCC515_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABHD2 abhydrolase domain containing 2
ACKR3 atypical chemokine receptor 3
ACOT7 acyl-CoA thioesterase 7
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHCY adenosylhomocysteinase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APLP2 amyloid beta (A4) precursor-like protein 2
AQP9 aquaporin 9
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASPN asporin
ATF3 activating transcription factor 3
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
BHLHE40 basic helix-loop-helix family, member e40
BHMT2 betaine--homocysteine S-methyltransferase 2
C2 complement component 2
C6ORF48 chromosome 6 open reading frame 48
CAV1 caveolin 1, caveolae protein, 22kDa
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CD24 CD24 molecule
CD302 CD302 molecule
CD52 CD52 molecule
CD84 CD84 molecule
CD9 CD9 molecule
CD93 CD93 molecule
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CECR1 cat eye syndrome chromosome region, candidate 1
CLEC11A C-type lectin domain family 11, member A
CLEC7A C-type lectin domain family 7, member A
CLU clusterin
COL18A1 collagen, type XVIII, alpha 1
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CSTA cystatin A (stefin A)
CSTB cystatin B (stefin B)
CTGF connective tissue growth factor
CUBN cubilin (intrinsic factor-cobalamin receptor)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
ECM1 extracellular matrix protein 1
ECM2 extracellular matrix protein 2, female organ and adipocyte specific
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ENPEP glutamyl aminopeptidase (aminopeptidase A)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
F8 coagulation factor VIII, procoagulant component
FGL2 fibrinogen-like 2
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FRZB frizzled-related protein
GATAD1 GATA zinc finger domain containing 1
GNPDA1 glucosamine-6-phosphate deaminase 1
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPR183 G protein-coupled receptor 183
GPX3 glutathione peroxidase 3
GUSBP3 glucuronidase, beta pseudogene 3
HBEGF heparin-binding EGF-like growth factor
HCAR3 hydroxycarboxylic acid receptor 3
HDAC9 histone deacetylase 9
HIP1 huntingtin interacting protein 1
HIST1H1C histone cluster 1, H1c
HIST1H4H histone cluster 1, H4h
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HRSP12 heat-responsive protein 12
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
IFI30 interferon, gamma-inducible protein 30
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
INSM1 insulinoma-associated 1
ISG15 ISG15 ubiquitin-like modifier
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAG1 jagged 1
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2
KYNU kynureninase
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LAMP3 lysosomal-associated membrane protein 3
LGALS3 lectin, galactoside-binding, soluble, 3
LY86 lymphocyte antigen 86
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAOA monoamine oxidase A
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MXI1 MAX interactor 1, dimerization protein
MXRA7 matrix-remodelling associated 7
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NOTCH3 notch 3
NPIPB3 nuclear pore complex interacting protein family, member B3
NQO2 NAD(P)H dehydrogenase, quinone 2
NR1D2 nuclear receptor subfamily 1, group D, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
OLFM1 olfactomedin 1
OLFML2A olfactomedin-like 2A
PCBP2 poly(rC) binding protein 2
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFD platelet derived growth factor D
PECAM1 platelet/endothelial cell adhesion molecule 1
PER3 period circadian clock 3
PGLS 6-phosphogluconolactonase
PHACTR1 phosphatase and actin regulator 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAGL1 pleiomorphic adenoma gene-like 1
PLAU plasminogen activator, urokinase
PLBD1 phospholipase B domain containing 1
PLVAP plasmalemma vesicle associated protein
PLXDC1 plexin domain containing 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROS1 protein S (alpha)
RABAC1 Rab acceptor 1 (prenylated)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAP1GAP RAP1 GTPase activating protein
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1
RGCC regulator of cell cycle
RGS5 regulator of G-protein signaling 5
RHOQ ras homolog family member Q
RIOK3 RIO kinase 3
RPS4Y1 ribosomal protein S4, Y-linked 1
RPS5 ribosomal protein S5
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SCARB2 scavenger receptor class B, member 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP4 secreted frizzled-related protein 4
SFTPC surfactant protein C
SH3YL1 SH3 and SYLF domain containing 1
SLC16A6 solute carrier family 16, member 6
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SMA4 glucuronidase, beta pseudogene
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SPARCL1 SPARC-like 1 (hevin)
STC1 stanniocalcin 1
STX1A syntaxin 1A (brain)
SYT1 synaptotagmin I
TENM1 teneurin transmembrane protein 1
TGFB1 transforming growth factor, beta 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TRBC1 T cell receptor beta constant 1
TSPAN12 tetraspanin 12
TSPAN31 tetraspanin 31
TSPAN6 tetraspanin 6
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
VDAC1 voltage-dependent anion channel 1
VEGFA vascular endothelial growth factor A
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BLMH bleomycin hydrolase
BMI1 BMI1 proto-oncogene, polycomb ring finger
C14ORF169 chromosome 14 open reading frame 169
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CASP8AP2 caspase 8 associated protein 2
CCNA2 cyclin A2
CDC123 cell division cycle 123
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK7 cyclin-dependent kinase 7
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EXOSC9 exosome component 9
FEN1 flap structure-specific endonuclease 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAR1 GAR1 ribonucleoprotein
GINS1 GINS complex subunit 1 (Psf1 homolog)
GRWD1 glutamate-rich WD repeat containing 1
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP4 insulin-like growth factor binding protein 4
IGHMBP2 immunoglobulin mu binding protein 2
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KEAP1 kelch-like ECH-associated protein 1
KIF1BP KIF1 binding protein
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT15 keratin 15, type I
LBR lamin B receptor
LMNB1 lamin B1
LTF lactotransferrin
MAK16 MAK16 homolog (S. cerevisiae)
MBNL1 muscleblind-like splicing regulator 1
MCM10 minichromosome maintenance complex component 10
MED1 mediator complex subunit 1
MSH6 mutS homolog 6
NASP nuclear autoantigenic sperm protein (histone-binding)
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFIL3 nuclear factor, interleukin 3 regulated
NGDN neuroguidin, EIF4E binding protein
NNMT nicotinamide N-methyltransferase
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae)
NOL11 nucleolar protein 11
NOP56 NOP56 ribonucleoprotein
NUP85 nucleoporin 85kDa
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PRPF4B pre-mRNA processing factor 4B
RAB14 RAB14, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RAE1 ribonucleic acid export 1
RBM34 RNA binding motif protein 34
RBM38 RNA binding motif protein 38
RFC4 replication factor C (activator 1) 4, 37kDa
RGS2 regulator of G-protein signaling 2
RNPS1 RNA binding protein S1, serine-rich domain
RPP38 ribonuclease P/MRP 38kDa subunit
SACS sacsin molecular chaperone
SEC24B SEC24 family member B
SLC38A2 solute carrier family 38, member 2
SMAD1 SMAD family member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TARDBP TAR DNA binding protein
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE4 transducin-like enhancer of split 4
TMPO thymopoietin
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOB1 transducer of ERBB2, 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC3 trafficking protein particle complex 3
TRIM2 tripartite motif containing 2
TXLNA taxilin alpha
UMPS uridine monophosphate synthetase
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
VCAN versican
ZFP36L2 ZFP36 ring finger protein-like 2