BRD-K19220233_JNK-9L_HA1E_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

297 genes differentially expressed following the BRD-K19220233_JNK-9L_HA1E_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AKR1C3 aldo-keto reductase family 1, member C3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
ANO1 anoctamin 1, calcium activated chloride channel
AOC3 amine oxidase, copper containing 3
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
ASPN asporin
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
BLNK B-cell linker
BTG2 BTG family, member 2
C1ORF106 chromosome 1 open reading frame 106
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C2 complement component 2
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CCRL2 chemokine (C-C motif) receptor-like 2
CD163 CD163 molecule
CD302 CD302 molecule
CD44 CD44 molecule (Indian blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD84 CD84 molecule
CD93 CD93 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEP70 centrosomal protein 70kDa
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC10A C-type lectin domain family 10, member A
CLEC2B C-type lectin domain family 2, member B
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL21A1 collagen, type XXI, alpha 1
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
COLEC12 collectin sub-family member 12
CPE carboxypeptidase E
CPM carboxypeptidase M
CRABP1 cellular retinoic acid binding protein 1
CSTA cystatin A (stefin A)
CTSK cathepsin K
CTSS cathepsin S
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYBB cytochrome b-245, beta polypeptide
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DHRS3 dehydrogenase/reductase (SDR family) member 3
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP4 dual specificity phosphatase 4
EDNRA endothelin receptor type A
EFHC2 EF-hand domain (C-terminal) containing 2
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EIF5A eukaryotic translation initiation factor 5A
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
EXPH5 exophilin 5
F13A1 coagulation factor XIII, A1 polypeptide
F3 coagulation factor III (thromboplastin, tissue factor)
FBLN1 fibulin 1
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FLT1 fms-related tyrosine kinase 1
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOXF2 forkhead box F2
FRMD4B FERM domain containing 4B
FRZB frizzled-related protein
FXYD3 FXYD domain containing ion transport regulator 3
GEM GTP binding protein overexpressed in skeletal muscle
GFOD1 glucose-fructose oxidoreductase domain containing 1
GLT8D2 glycosyltransferase 8 domain containing 2
GLUL glutamate-ammonia ligase
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GSAP gamma-secretase activating protein
GSN gelsolin
GUSBP3 glucuronidase, beta pseudogene 3
GZMK granzyme K (granzyme 3; tryptase II)
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HMGA1 high mobility group AT-hook 1
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IGSF6 immunoglobulin superfamily, member 6
IL13RA2 interleukin 13 receptor, alpha 2
IL1A interleukin 1, alpha
IL7R interleukin 7 receptor
IRF6 interferon regulatory factor 6
ISYNA1 inositol-3-phosphate synthase 1
ITFG1 integrin alpha FG-GAP repeat containing 1
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2A integral membrane protein 2A
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LAMP2 lysosomal-associated membrane protein 2
LAMP3 lysosomal-associated membrane protein 3
LAPTM5 lysosomal protein transmembrane 5
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPPR4 lipid phosphate phosphatase-related protein type 4
LRRC17 leucine rich repeat containing 17
LTB lymphotoxin beta (TNF superfamily, member 3)
LTBP1 latent transforming growth factor beta binding protein 1
LYZ lysozyme
MAN1C1 mannosidase, alpha, class 1C, member 1
MDFIC MyoD family inhibitor domain containing
MECOM MDS1 and EVI1 complex locus
MEF2C myocyte enhancer factor 2C
MMP9 matrix metallopeptidase 9
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MSR1 macrophage scavenger receptor 1
MXRA5 matrix-remodelling associated 5
NCF2 neutrophil cytosolic factor 2
NEBL nebulette
NID1 nidogen 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
PARM1 prostate androgen-regulated mucin-like protein 1
PCLO piccolo presynaptic cytomatrix protein
PCOLCE procollagen C-endopeptidase enhancer
PCOLCE2 procollagen C-endopeptidase enhancer 2
PEG3 paternally expressed 3
PLTP phospholipid transfer protein
PLVAP plasmalemma vesicle associated protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS21 protease, serine, 21 (testisin)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTN pleiotrophin
PTPRC protein tyrosine phosphatase, receptor type, C
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL31 ribosomal protein L31
S100A8 S100 calcium binding protein A8
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SCGB2A1 secretoglobin, family 2A, member 1
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SIDT1 SID1 transmembrane family, member 1
SIK1 salt-inducible kinase 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPARCL1 SPARC-like 1 (hevin)
SPDEF SAM pointed domain containing ETS transcription factor
SPON1 spondin 1, extracellular matrix protein
SSPN sarcospan
ST18 suppression of tumorigenicity 18, zinc finger
STC1 stanniocalcin 1
SULF1 sulfatase 1
SYBU syntabulin (syntaxin-interacting)
TCTN1 tectonic family member 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM231 transmembrane protein 231
TMEM30B transmembrane protein 30B
TMEM45A transmembrane protein 45A
TOX thymocyte selection-associated high mobility group box
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TWIST1 twist family bHLH transcription factor 1
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
VWA5A von Willebrand factor A domain containing 5A
ZNF264 zinc finger protein 264
ZNF331 zinc finger protein 331
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACSL1 acyl-CoA synthetase long-chain family member 1
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMD1 adenosylmethionine decarboxylase 1
ASCC3 activating signal cointegrator 1 complex subunit 3
ATG3 autophagy related 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BLMH bleomycin hydrolase
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CKS2 CDC28 protein kinase regulatory subunit 2
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CRYAB crystallin, alpha B
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DRG1 developmentally regulated GTP binding protein 1
EIF4E eukaryotic translation initiation factor 4E
GINS2 GINS complex subunit 2 (Psf2 homolog)
GRSF1 G-rich RNA sequence binding factor 1
HDAC2 histone deacetylase 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
KRT7 keratin 7, type II
LBR lamin B receptor
LSM6 LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LXN latexin
MARCKS myristoylated alanine-rich protein kinase C substrate
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MRPS2 mitochondrial ribosomal protein S2
MYBPC1 myosin binding protein C, slow type
NNMT nicotinamide N-methyltransferase
NOP56 NOP56 ribonucleoprotein
PACSIN2 protein kinase C and casein kinase substrate in neurons 2
PARP2 poly (ADP-ribose) polymerase 2
PAX8 paired box 8
PCM1 pericentriolar material 1
PCNA proliferating cell nuclear antigen
PDS5A PDS5 cohesin associated factor A
PFKP phosphofructokinase, platelet
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP4 processing of precursor 4, ribonuclease P/MRP subunit (S. cerevisiae)
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RACGAP1 Rac GTPase activating protein 1
RAE1 ribonucleic acid export 1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RFC4 replication factor C (activator 1) 4, 37kDa
S100A10 S100 calcium binding protein A10
SERBP1 SERPINE1 mRNA binding protein 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TBC1D4 TBC1 domain family, member 4
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMEM100 transmembrane protein 100
TMPO thymopoietin
TNS1 tensin 1
TRAPPC3 trafficking protein particle complex 3
TRAPPC4 trafficking protein particle complex 4
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
TXNDC9 thioredoxin domain containing 9
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
VCAN versican
VPS26A vacuolar protein sorting 26 homolog A (S. pombe)
VRK1 vaccinia related kinase 1
XBP1 X-box binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon