BRD-K19220233_JNK-9L_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

295 genes differentially expressed following the BRD-K19220233_JNK-9L_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ACKR3 atypical chemokine receptor 3
ADCY1 adenylate cyclase 1 (brain)
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AIF1 allograft inflammatory factor 1
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANGPTL2 angiopoietin-like 2
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
ATP1B2 ATPase, Na+/K+ transporting, beta 2 polypeptide
BEX4 brain expressed, X-linked 4
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CA11 carbonic anhydrase XI
CA2 carbonic anhydrase II
CALB1 calbindin 1, 28kDa
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CCNA1 cyclin A1
CCR1 chemokine (C-C motif) receptor 1
CD163 CD163 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CD93 CD93 molecule
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CECR1 cat eye syndrome chromosome region, candidate 1
CES2 carboxylesterase 2
CHERP calcium homeostasis endoplasmic reticulum protein
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
COL3A1 collagen, type III, alpha 1
COL6A3 collagen, type VI, alpha 3
COL9A2 collagen, type IX, alpha 2
COLEC12 collectin sub-family member 12
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CTSC cathepsin C
CTSK cathepsin K
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
DKK3 dickkopf WNT signaling pathway inhibitor 3
DUSP6 dual specificity phosphatase 6
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB4 erb-b2 receptor tyrosine kinase 4
ERLIN2 ER lipid raft associated 2
ESR1 estrogen receptor 1
ETHE1 ethylmalonic encephalopathy 1
FAM131A family with sequence similarity 131, member A
FAM46A family with sequence similarity 46, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
GAD1 glutamate decarboxylase 1 (brain, 67kDa)
GJA1 gap junction protein, alpha 1, 43kDa
GLUL glutamate-ammonia ligase
GM2A GM2 ganglioside activator
GPC4 glypican 4
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GSTT1 glutathione S-transferase theta 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IL13RA2 interleukin 13 receptor, alpha 2
ISYNA1 inositol-3-phosphate synthase 1
ITFG1 integrin alpha FG-GAP repeat containing 1
ITM2A integral membrane protein 2A
JAG1 jagged 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLK10 kallikrein-related peptidase 10
LAMP3 lysosomal-associated membrane protein 3
LOC100507397 uncharacterized LOC100507397
LPCAT4 lysophosphatidylcholine acyltransferase 4
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1C1 mannosidase, alpha, class 1C, member 1
METRN meteorin, glial cell differentiation regulator
MICB MHC class I polypeptide-related sequence B
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MXRA5 matrix-remodelling associated 5
NCDN neurochondrin
NDFIP1 Nedd4 family interacting protein 1
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa
NELL2 NEL-like 2 (chicken)
NID1 nidogen 1
NMU neuromedin U
NOX4 NADPH oxidase 4
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRGN neurogranin (protein kinase C substrate, RC3)
OLFM1 olfactomedin 1
ORAI2 ORAI calcium release-activated calcium modulator 2
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PARM1 prostate androgen-regulated mucin-like protein 1
PAX6 paired box 6
PCLO piccolo presynaptic cytomatrix protein
PCOLCE procollagen C-endopeptidase enhancer
PCSK1 proprotein convertase subtilisin/kexin type 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEG3 paternally expressed 3
PLTP phospholipid transfer protein
PNMAL1 paraneoplastic Ma antigen family-like 1
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS21 protease, serine, 21 (testisin)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RNASE6 ribonuclease, RNase A family, k6
RNASET2 ribonuclease T2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPL31 ribosomal protein L31
SCG2 secretogranin II
SCG5 secretogranin V
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
SNX10 sorting nexin 10
SPDEF SAM pointed domain containing ETS transcription factor
SPINK4 serine peptidase inhibitor, Kazal type 4
SPON1 spondin 1, extracellular matrix protein
SSPN sarcospan
ST18 suppression of tumorigenicity 18, zinc finger
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFB1 transforming growth factor, beta 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM176B transmembrane protein 176B
TMEM30B transmembrane protein 30B
TOX thymocyte selection-associated high mobility group box
TPGS2 tubulin polyglutamylase complex subunit 2
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TWIST1 twist family bHLH transcription factor 1
TYROBP TYRO protein tyrosine kinase binding protein
VWA5A von Willebrand factor A domain containing 5A
ZNF264 zinc finger protein 264
ZNF304 zinc finger protein 304
ZNF331 zinc finger protein 331
ZNF551 zinc finger protein 551
ZNF91 zinc finger protein 91
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTA1 actin, alpha 1, skeletal muscle
ACTC1 actin, alpha, cardiac muscle 1
ADGRG2 adhesion G protein-coupled receptor G2
AK1 adenylate kinase 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
AMD1 adenosylmethionine decarboxylase 1
ANXA2P2 annexin A2 pseudogene 2
ANXA3 annexin A3
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ASF1A anti-silencing function 1A histone chaperone
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BIN1 bridging integrator 1
BLMH bleomycin hydrolase
C4ORF27 chromosome 4 open reading frame 27
C9ORF3 chromosome 9 open reading frame 3
CBR3 carbonyl reductase 3
CD24 CD24 molecule
CD58 CD58 molecule
CD59 CD59 molecule, complement regulatory protein
CDC25B cell division cycle 25B
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CENPU centromere protein U
CEP170 centrosomal protein 170kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CNN1 calponin 1, basic, smooth muscle
CRISP3 cysteine-rich secretory protein 3
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DES desmin
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DPYSL2 dihydropyrimidinase-like 2
EIF4E eukaryotic translation initiation factor 4E
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4
FAM129A family with sequence similarity 129, member A
GALE UDP-galactose-4-epimerase
GRB10 growth factor receptor-bound protein 10
GYG1 glycogenin 1
H1F0 H1 histone family, member 0
HMGB1 high mobility group box 1
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
KRT7 keratin 7, type II
LXN latexin
MAB21L2 mab-21-like 2 (C. elegans)
MAP1B microtubule-associated protein 1B
MBNL1 muscleblind-like splicing regulator 1
MET MET proto-oncogene, receptor tyrosine kinase
MGP matrix Gla protein
MICALL1 MICAL-like 1
MPZL1 myelin protein zero-like 1
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYBPC1 myosin binding protein C, slow type
MYO10 myosin X
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEK7 NIMA-related kinase 7
NKX3-1 NK3 homeobox 1
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
PARP2 poly (ADP-ribose) polymerase 2
PAX8 paired box 8
PCM1 pericentriolar material 1
PDS5A PDS5 cohesin associated factor A
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PROM1 prominin 1
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PUF60 poly-U binding splicing factor 60KDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RCAN1 regulator of calcineurin 1
RDX radixin
S100A7 S100 calcium binding protein A7
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35F2 solute carrier family 35, member F2
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLIT2 slit homolog 2 (Drosophila)
SLN sarcolipin
SLPI secretory leukocyte peptidase inhibitor
SMC4 structural maintenance of chromosomes 4
SRSF3 serine/arginine-rich splicing factor 3
STMN1 stathmin 1
SYNM synemin, intermediate filament protein
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM100 transmembrane protein 100
TMPO thymopoietin
TNS1 tensin 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TRAK2 trafficking protein, kinesin binding 2
TRIM29 tripartite motif containing 29
TSPYL5 TSPY-like 5
TST thiosulfate sulfurtransferase (rhodanese)
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UBL3 ubiquitin-like 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
VRK1 vaccinia related kinase 1
ZDHHC6 zinc finger, DHHC-type containing 6
ZWILCH zwilch kinetochore protein