BRD-K19220233_JNK-9L_HA1E_24_h_0.37_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

237 genes differentially expressed following the BRD-K19220233_JNK-9L_HA1E_24_h_0.37_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AHNAK2 AHNAK nucleoprotein 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ANKRD10 ankyrin repeat domain 10
BCL6 B-cell CLL/lymphoma 6
BECN1 beclin 1, autophagy related
BST2 bone marrow stromal cell antigen 2
C1RL complement component 1, r subcomponent-like
CBR1 carbonyl reductase 1
CD52 CD52 molecule
CDCP1 CUB domain containing protein 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLU clusterin
COASY CoA synthase
COG4 component of oligomeric golgi complex 4
CPE carboxypeptidase E
CYB561 cytochrome b561
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
EPAS1 endothelial PAS domain protein 1
EVI2B ecotropic viral integration site 2B
FBXW2 F-box and WD repeat domain containing 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HEXIM1 hexamethylene bis-acetamide inducible 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGFBP6 insulin-like growth factor binding protein 6
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
LYN LYN proto-oncogene, Src family tyrosine kinase
MCOLN1 mucolipin 1
NBEA neurobeachin
NMU neuromedin U
NPY1R neuropeptide Y receptor Y1
OLFM1 olfactomedin 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PLAC8 placenta-specific 8
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKX protein kinase, X-linked
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RBM47 RNA binding motif protein 47
SCG5 secretogranin V
STX3 syntaxin 3
SURF1 surfeit 1
TCEA2 transcription elongation factor A (SII), 2
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3
TERF2 telomeric repeat binding factor 2
TFPI2 tissue factor pathway inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM223 transmembrane protein 223
TOR1A torsin family 1, member A (torsin A)
TRIM14 tripartite motif containing 14
TSPAN12 tetraspanin 12
TSPAN4 tetraspanin 4
VWA5A von Willebrand factor A domain containing 5A
ZNF544 zinc finger protein 544

decreased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ADAM12 ADAM metallopeptidase domain 12
ADGRG1 adhesion G protein-coupled receptor G1
AMIGO2 adhesion molecule with Ig-like domain 2
ANO1 anoctamin 1, calcium activated chloride channel
APOD apolipoprotein D
ARID5B AT rich interactive domain 5B (MRF1-like)
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BGN biglycan
C3ORF14 chromosome 3 open reading frame 14
CA12 carbonic anhydrase XII
CCL2 chemokine (C-C motif) ligand 2
CCR7 chemokine (C-C motif) receptor 7
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFLAR CASP8 and FADD-like apoptosis regulator
CH25H cholesterol 25-hydroxylase
CNN1 calponin 1, basic, smooth muscle
COL1A1 collagen, type I, alpha 1
COL5A2 collagen, type V, alpha 2
COL9A3 collagen, type IX, alpha 3
CRIP2 cysteine-rich protein 2
CSRP1 cysteine and glycine-rich protein 1
CX3CL1 chemokine (C-X3-C motif) ligand 1
DAAM1 dishevelled associated activator of morphogenesis 1
DACT1 dishevelled-binding antagonist of beta-catenin 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DHCR7 7-dehydrocholesterol reductase
DLK1 delta-like 1 homolog (Drosophila)
DLX2 distal-less homeobox 2
DMD dystrophin
DSE dermatan sulfate epimerase
DST dystonin
EDN1 endothelin 1
EGF epidermal growth factor
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
F13A1 coagulation factor XIII, A1 polypeptide
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FASN fatty acid synthase
FBN1 fibrillin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR2 fibroblast growth factor receptor 2
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
GBP1 guanylate binding protein 1, interferon-inducible
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
HAPLN1 hyaluronan and proteoglycan link protein 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HNMT histamine N-methyltransferase
HOMER2 homer scaffolding protein 2
HOXC6 homeobox C6
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
ICAM1 intercellular adhesion molecule 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGSF3 immunoglobulin superfamily, member 3
IL32 interleukin 32
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
ITGAV integrin, alpha V
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LAMP5 lysosomal-associated membrane protein family, member 5
LDLR low density lipoprotein receptor
LIMS1 LIM and senescent cell antigen-like domains 1
LMCD1 LIM and cysteine-rich domains 1
LOX lysyl oxidase
LRRC17 leucine rich repeat containing 17
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAGED1 melanoma antigen family D1
MAN1A1 mannosidase, alpha, class 1A, member 1
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
MEIS2 Meis homeobox 2
MPPED2 metallophosphoesterase domain containing 2
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MYBPC1 myosin binding protein C, slow type
MYLK myosin light chain kinase
NAV3 neuron navigator 3
NDRG1 N-myc downstream regulated 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEK7 NIMA-related kinase 7
NME4 NME/NM23 nucleoside diphosphate kinase 4
NXN nucleoredoxin
OSBPL8 oxysterol binding protein-like 8
PALLD palladin, cytoskeletal associated protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP prolactin-induced protein
PLAGL1 pleiomorphic adenoma gene-like 1
PLAT plasminogen activator, tissue
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLP1 proteolipid protein 1
PRAME preferentially expressed antigen in melanoma
PROM1 prominin 1
PRSS21 protease, serine, 21 (testisin)
PSAT1 phosphoserine aminotransferase 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTK7 protein tyrosine kinase 7 (inactive)
PWP1 PWP1 homolog (S. cerevisiae)
PYCR1 pyrroline-5-carboxylate reductase 1
RCN3 reticulocalbin 3, EF-hand calcium binding domain
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RHOBTB3 Rho-related BTB domain containing 3
RNF130 ring finger protein 130
RNH1 ribonuclease/angiogenin inhibitor 1
S100A10 S100 calcium binding protein A10
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCML1 sex comb on midleg-like 1 (Drosophila)
SDC2 syndecan 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERINC5 serine incorporator 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SH3YL1 SH3 and SYLF domain containing 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC31A2 solute carrier family 31 (copper transporter), member 2
SNAI2 snail family zinc finger 2
SOX10 SRY (sex determining region Y)-box 10
SQLE squalene epoxidase
STMN1 stathmin 1
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACSTD2 tumor-associated calcium signal transducer 2
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBI transforming growth factor, beta-induced, 68kDa
THBS2 thrombospondin 2
TLE4 transducin-like enhancer of split 4
TMSB15A thymosin beta 15a
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
WNT5A wingless-type MMTV integration site family, member 5A
XBP1 X-box binding protein 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF292 zinc finger protein 292