BRD-K19220233_JNK-9L_BT20_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

234 genes differentially expressed following the BRD-K19220233_JNK-9L_BT20_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
ADAM9 ADAM metallopeptidase domain 9
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKRD10 ankyrin repeat domain 10
AOX1 aldehyde oxidase 1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
AQP9 aquaporin 9
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACE2 beta-site APP-cleaving enzyme 2
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C5AR1 complement component 5a receptor 1
CALD1 caldesmon 1
CCDC92 coiled-coil domain containing 92
CCL20 chemokine (C-C motif) ligand 20
CCL4 chemokine (C-C motif) ligand 4
CD163 CD163 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL6A1 collagen, type VI, alpha 1
CPE carboxypeptidase E
CTGF connective tissue growth factor
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
DST dystonin
DUSP2 dual specificity phosphatase 2
DYNLT3 dynein, light chain, Tctex-type 3
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
ELN elastin
ERBB4 erb-b2 receptor tyrosine kinase 4
ESR1 estrogen receptor 1
F13A1 coagulation factor XIII, A1 polypeptide
FAM46A family with sequence similarity 46, member A
FLRT2 fibronectin leucine rich transmembrane protein 2
FST follistatin
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLIPR1 GLI pathogenesis-related 1
GLUL glutamate-ammonia ligase
GNB5 guanine nucleotide binding protein (G protein), beta 5
GOLM1 golgi membrane protein 1
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GPX3 glutathione peroxidase 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HMOX1 heme oxygenase 1
HPSE heparanase
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IDS iduronate 2-sulfatase
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
IL6ST interleukin 6 signal transducer
ITM2A integral membrane protein 2A
LMO3 LIM domain only 3 (rhombotin-like 2)
LOX lysyl oxidase
LRRC15 leucine rich repeat containing 15
MAP2 microtubule-associated protein 2
MDFIC MyoD family inhibitor domain containing
MEF2C myocyte enhancer factor 2C
MMP9 matrix metallopeptidase 9
MSN moesin
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
NDFIP1 Nedd4 family interacting protein 1
NELL2 NEL-like 2 (chicken)
NR4A2 nuclear receptor subfamily 4, group A, member 2
PALLD palladin, cytoskeletal associated protein
PCBP2 poly(rC) binding protein 2
PEG3 paternally expressed 3
PHACTR1 phosphatase and actin regulator 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLVAP plasmalemma vesicle associated protein
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCB protein kinase C, beta
PTN pleiotrophin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
REEP5 receptor accessory protein 5
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRAGD Ras-related GTP binding D
SCG5 secretogranin V
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP4 secreted frizzled-related protein 4
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SPARCL1 SPARC-like 1 (hevin)
SPON1 spondin 1, extracellular matrix protein
SST somatostatin
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TAGLN transgelin
TFPI2 tissue factor pathway inhibitor 2
THBS4 thrombospondin 4
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM45A transmembrane protein 45A
TNNT1 troponin T type 1 (skeletal, slow)
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TSPAN7 tetraspanin 7
TTC3 tetratricopeptide repeat domain 3
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADGRG2 adhesion G protein-coupled receptor G2
ADGRG6 adhesion G protein-coupled receptor G6
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATG3 autophagy related 3
ATMIN ATM interactor
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
CALML3 calmodulin-like 3
CALML5 calmodulin-like 5
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDK19 cyclin-dependent kinase 19
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CKS2 CDC28 protein kinase regulatory subunit 2
CLTA clathrin, light chain A
COL9A3 collagen, type IX, alpha 3
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTBP2 C-terminal binding protein 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
ELF5 E74-like factor 5 (ets domain transcription factor)
ERBB2 erb-b2 receptor tyrosine kinase 2
FA2H fatty acid 2-hydroxylase
FGFR2 fibroblast growth factor receptor 2
FZD7 frizzled class receptor 7
GATA3 GATA binding protein 3
GLOD4 glyoxalase domain containing 4
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GPX2 glutathione peroxidase 2
GTF2A2 general transcription factor IIA, 2, 12kDa
H2AFX H2A histone family, member X
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGKV1-5 immunoglobulin kappa variable 1-5
IVNS1ABP influenza virus NS1A binding protein
JCHAIN joining chain of multimeric IgA and IgM
KARS lysyl-tRNA synthetase
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
KLK6 kallikrein-related peptidase 6
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LASP1 LIM and SH3 protein 1
LMNB1 lamin B1
MBNL2 muscleblind-like splicing regulator 2
MED1 mediator complex subunit 1
MELK maternal embryonic leucine zipper kinase
MICALL1 MICAL-like 1
MMP7 matrix metallopeptidase 7
MRPS2 mitochondrial ribosomal protein S2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEK2 NIMA-related kinase 2
NNMT nicotinamide N-methyltransferase
NOTCH2 notch 2
NXN nucleoredoxin
OPN3 opsin 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
PMP22 peripheral myelin protein 22
PSCA prostate stem cell antigen
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
RABGAP1 RAB GTPase activating protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A6 S100 calcium binding protein A6
S100A7 S100 calcium binding protein A7
SET SET nuclear proto-oncogene
SF3B3 splicing factor 3b, subunit 3, 130kDa
SFN stratifin
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMC4 structural maintenance of chromosomes 4
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TLE4 transducin-like enhancer of split 4
TMX4 thioredoxin-related transmembrane protein 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TP53 tumor protein p53
TPM1 tropomyosin 1 (alpha)
TRIM29 tripartite motif containing 29
TSPYL5 TSPY-like 5
TUBA1A tubulin, alpha 1a
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
USP10 ubiquitin specific peptidase 10