BRD-K19220233_JNK-9L_BT20_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

242 genes differentially expressed following the BRD-K19220233_JNK-9L_BT20_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ADGRF5 adhesion G protein-coupled receptor F5
ADRBK1 adrenergic, beta, receptor kinase 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit
ANKRD36B ankyrin repeat domain 36B
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
AQP9 aquaporin 9
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL2L1 BCL2-like 1
BHMT2 betaine--homocysteine S-methyltransferase 2
BLNK B-cell linker
C5AR1 complement component 5a receptor 1
CALB1 calbindin 1, 28kDa
CCL20 chemokine (C-C motif) ligand 20
CFB complement factor B
CFI complement factor I
COL11A1 collagen, type XI, alpha 1
CPD carboxypeptidase D
CPE carboxypeptidase E
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
DST dystonin
DUSP2 dual specificity phosphatase 2
ECHDC2 enoyl CoA hydratase domain containing 2
ECM1 extracellular matrix protein 1
EGR1 early growth response 1
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPCAM epithelial cell adhesion molecule
ERBB4 erb-b2 receptor tyrosine kinase 4
F13A1 coagulation factor XIII, A1 polypeptide
FGF13 fibroblast growth factor 13
FLRT2 fibronectin leucine rich transmembrane protein 2
FOLR1 folate receptor 1 (adult)
FPR1 formyl peptide receptor 1
FRY furry homolog (Drosophila)
FST follistatin
G0S2 G0/G1 switch 2
GAS6 growth arrest-specific 6
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLUL glutamate-ammonia ligase
GNB5 guanine nucleotide binding protein (G protein), beta 5
GOLGA8B golgin A8 family, member B
GPNMB glycoprotein (transmembrane) nmb
GSAP gamma-secretase activating protein
GUCY1B3 guanylate cyclase 1, soluble, beta 3
GUK1 guanylate kinase 1
GUSBP3 glucuronidase, beta pseudogene 3
HCLS1 hematopoietic cell-specific Lyn substrate 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HP haptoglobin
HRSP12 heat-responsive protein 12
IDS iduronate 2-sulfatase
IFI30 interferon, gamma-inducible protein 30
IFRD2 interferon-related developmental regulator 2
IGFBP3 insulin-like growth factor binding protein 3
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LAMP3 lysosomal-associated membrane protein 3
LMO3 LIM domain only 3 (rhombotin-like 2)
LYN LYN proto-oncogene, Src family tyrosine kinase
MDFIC MyoD family inhibitor domain containing
METTL5 methyltransferase like 5
MXRA5 matrix-remodelling associated 5
MXRA7 matrix-remodelling associated 7
MYO1B myosin IB
NDFIP1 Nedd4 family interacting protein 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
PCBP2 poly(rC) binding protein 2
PDE4A phosphodiesterase 4A, cAMP-specific
PECAM1 platelet/endothelial cell adhesion molecule 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PLVAP plasmalemma vesicle associated protein
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP4 retinol binding protein 4, plasma
REEP5 receptor accessory protein 5
RRAGD Ras-related GTP binding D
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1
SCARB2 scavenger receptor class B, member 2
SDC2 syndecan 2
SDHAF3 succinate dehydrogenase complex assembly factor 3
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SMYD3 SET and MYND domain containing 3
SRPR signal recognition particle receptor (docking protein)
SSR4 signal sequence receptor, delta
STC1 stanniocalcin 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
STK38L serine/threonine kinase 38 like
STXBP6 syntaxin binding protein 6 (amisyn)
TF transferrin
TGFB1 transforming growth factor, beta 1
TGOLN2 trans-golgi network protein 2
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMEM259 transmembrane protein 259
TPP1 tripeptidyl peptidase I
TRA2A transformer 2 alpha homolog (Drosophila)
TSPAN7 tetraspanin 7
TUSC3 tumor suppressor candidate 3
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADGRG6 adhesion G protein-coupled receptor G6
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AQP3 aquaporin 3 (Gill blood group)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATMIN ATM interactor
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BLCAP bladder cancer associated protein
CAB39 calcium binding protein 39
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25B cell division cycle 25B
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK19 cyclin-dependent kinase 19
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CLTA clathrin, light chain A
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
EIF6 eukaryotic translation initiation factor 6
ERBB2 erb-b2 receptor tyrosine kinase 2
FA2H fatty acid 2-hydroxylase
FBXO21 F-box protein 21
FGFR2 fibroblast growth factor receptor 2
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAL galanin/GMAP prepropeptide
GATA3 GATA binding protein 3
GLOD4 glyoxalase domain containing 4
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPSM2 G-protein signaling modulator 2
GPX2 glutathione peroxidase 2
H2AFX H2A histone family, member X
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IST1 increased sodium tolerance 1 homolog (yeast)
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
KLK6 kallikrein-related peptidase 6
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT7 keratin 7, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LBR lamin B receptor
LMNB1 lamin B1
LY6D lymphocyte antigen 6 complex, locus D
MALL mal, T-cell differentiation protein-like
MARCKS myristoylated alanine-rich protein kinase C substrate
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
NEK2 NIMA-related kinase 2
NNMT nicotinamide N-methyltransferase
NOP56 NOP56 ribonucleoprotein
NOSIP nitric oxide synthase interacting protein
NOTCH2 notch 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRIP1 nuclear receptor interacting protein 1
NSFL1C NSFL1 (p97) cofactor (p47)
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP62 nucleoporin 62kDa
NUSAP1 nucleolar and spindle associated protein 1
OPN3 opsin 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
PNP purine nucleoside phosphorylase
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PUM1 pumilio RNA-binding family member 1
RAD23B RAD23 homolog B (S. cerevisiae)
RAE1 ribonucleic acid export 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNF114 ring finger protein 114
RNPS1 RNA binding protein S1, serine-rich domain
S100A6 S100 calcium binding protein A6
S100A7 S100 calcium binding protein A7
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SETX senataxin
SFN stratifin
SLC38A2 solute carrier family 38, member 2
SLPI secretory leukocyte peptidase inhibitor
SMC4 structural maintenance of chromosomes 4
SNRPB2 small nuclear ribonucleoprotein polypeptide B
SOX9 SRY (sex determining region Y)-box 9
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE4 transducin-like enhancer of split 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TP53 tumor protein p53
TPD52L1 tumor protein D52-like 1
TPX2 TPX2, microtubule-associated
TRAPPC3 trafficking protein particle complex 3
TUBB4B tubulin, beta 4B class IVb
TXLNA taxilin alpha
TXNRD1 thioredoxin reductase 1
U2AF1 U2 small nuclear RNA auxiliary factor 1
UBE2C ubiquitin-conjugating enzyme E2C
UBE2I ubiquitin-conjugating enzyme E2I
USP22 ubiquitin specific peptidase 22
VCP valosin containing protein
WDR82 WD repeat domain 82