BRD-K19220233_JNK-9L_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

273 genes differentially expressed following the BRD-K19220233_JNK-9L_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AHCY adenosylhomocysteinase
AIF1 allograft inflammatory factor 1
AKAP8L A kinase (PRKA) anchor protein 8-like
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANKRD10 ankyrin repeat domain 10
ANXA9 annexin A9
AOX1 aldehyde oxidase 1
APLP2 amyloid beta (A4) precursor-like protein 2
AQP1 aquaporin 1 (Colton blood group)
ATF3 activating transcription factor 3
BHLHE40 basic helix-loop-helix family, member e40
BHMT2 betaine--homocysteine S-methyltransferase 2
BTG2 BTG family, member 2
C3 complement component 3
C6ORF48 chromosome 6 open reading frame 48
CALD1 caldesmon 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL8 chemokine (C-C motif) ligand 8
CCND1 cyclin D1
CD52 CD52 molecule
CD93 CD93 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CFD complement factor D (adipsin)
CLDN3 claudin 3
COL6A3 collagen, type VI, alpha 3
CPE carboxypeptidase E
CPVL carboxypeptidase, vitellogenic-like
CTGF connective tissue growth factor
CTSS cathepsin S
CTTN cortactin
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DENND1A DENN/MADD domain containing 1A
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EGR1 early growth response 1
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
EPAS1 endothelial PAS domain protein 1
F3 coagulation factor III (thromboplastin, tissue factor)
FAM134B family with sequence similarity 134, member B
FAM63A family with sequence similarity 63, member A
FHL2 four and a half LIM domains 2
FMO2 flavin containing monooxygenase 2 (non-functional)
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FRS2 fibroblast growth factor receptor substrate 2
FZD6 frizzled class receptor 6
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GGT1 gamma-glutamyltransferase 1
GM2A GM2 ganglioside activator
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GSTM3 glutathione S-transferase mu 3 (brain)
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-E major histocompatibility complex, class I, E
HMGA1 high mobility group AT-hook 1
HMOX1 heme oxygenase 1
HOMER2 homer scaffolding protein 2
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM3 intercellular adhesion molecule 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDS iduronate 2-sulfatase
IFI30 interferon, gamma-inducible protein 30
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGFBP6 insulin-like growth factor binding protein 6
IGHM immunoglobulin heavy constant mu
IL7R interleukin 7 receptor
IRF8 interferon regulatory factor 8
ISG15 ISG15 ubiquitin-like modifier
ISYNA1 inositol-3-phosphate synthase 1
JAG1 jagged 1
JUN jun proto-oncogene
KLF10 Kruppel-like factor 10
KRT23 keratin 23, type I
LAMP1 lysosomal-associated membrane protein 1
LPPR4 lipid phosphate phosphatase-related protein type 4
LSR lipolysis stimulated lipoprotein receptor
LTB lymphotoxin beta (TNF superfamily, member 3)
LY86 lymphocyte antigen 86
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDFIC MyoD family inhibitor domain containing
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MMP1 matrix metallopeptidase 1
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MT1E metallothionein 1E
MT1F metallothionein 1F
MYC v-myc avian myelocytomatosis viral oncogene homolog
NMU neuromedin U
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI2 ORAI calcium release-activated calcium modulator 2
OVGP1 oviductal glycoprotein 1, 120kDa
OXCT1 3-oxoacid CoA transferase 1
PDE2A phosphodiesterase 2A, cGMP-stimulated
PECAM1 platelet/endothelial cell adhesion molecule 1
PER2 period circadian clock 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAGL1 pleiomorphic adenoma gene-like 1
PLAU plasminogen activator, urokinase
PLS3 plastin 3
PLVAP plasmalemma vesicle associated protein
PLXDC1 plexin domain containing 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRC protein tyrosine phosphatase, receptor type, C
RBP1 retinol binding protein 1, cellular
RBP4 retinol binding protein 4, plasma
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
RGS5 regulator of G-protein signaling 5
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPC surfactant protein C
SLC35E3 solute carrier family 35, member E3
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SLPI secretory leukocyte peptidase inhibitor
SMYD3 SET and MYND domain containing 3
SSR4 signal sequence receptor, delta
STC1 stanniocalcin 1
SYNE2 spectrin repeat containing, nuclear envelope 2
TFPI2 tissue factor pathway inhibitor 2
THBD thrombomodulin
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRH thyrotropin-releasing hormone
TRIM22 tripartite motif containing 22
TSPAN7 tetraspanin 7
TYROBP TYRO protein tyrosine kinase binding protein
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VEGFA vascular endothelial growth factor A
VTCN1 V-set domain containing T cell activation inhibitor 1
ZMAT3 zinc finger, matrin-type 3
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
AMD1 adenosylmethionine decarboxylase 1
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASF1A anti-silencing function 1A histone chaperone
ASXL2 additional sex combs like transcriptional regulator 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AURKA aurora kinase A
AURKB aurora kinase B
AUTS2 autism susceptibility candidate 2
BTBD3 BTB (POZ) domain containing 3
CA12 carbonic anhydrase XII
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBR1 carbonyl reductase 1
CCNA2 cyclin A2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDK7 cyclin-dependent kinase 7
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
COG2 component of oligomeric golgi complex 2
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CTBP2 C-terminal binding protein 2
DICER1 dicer 1, ribonuclease type III
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EED embryonic ectoderm development
EIF4E eukaryotic translation initiation factor 4E
ETV1 ets variant 1
FASTKD5 FAST kinase domains 5
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FEN1 flap structure-specific endonuclease 1
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FZD7 frizzled class receptor 7
GPATCH8 G patch domain containing 8
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HNMT histamine N-methyltransferase
HOXA10 homeobox A10
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
IDI1 isopentenyl-diphosphate delta isomerase 1
IRS2 insulin receptor substrate 2
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KEAP1 kelch-like ECH-associated protein 1
KLHL9 kelch-like family member 9
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MSH6 mutS homolog 6
MTSS1 metastasis suppressor 1
MYBPC1 myosin binding protein C, slow type
NAE1 NEDD8 activating enzyme E1 subunit 1
NOL11 nucleolar protein 11
PCNA proliferating cell nuclear antigen
PDCD10 programmed cell death 10
PDHX pyruvate dehydrogenase complex, component X
PLIN2 perilipin 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCD protein kinase C, delta
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PUF60 poly-U binding splicing factor 60KDa
PWP1 PWP1 homolog (S. cerevisiae)
RAB14 RAB14, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RIN2 Ras and Rab interactor 2
SF3B3 splicing factor 3b, subunit 3, 130kDa
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMAD1 SMAD family member 1
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPINK1 serine peptidase inhibitor, Kazal type 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYPL1 synaptophysin-like 1
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBC1D4 TBC1 domain family, member 4
TIAM1 T-cell lymphoma invasion and metastasis 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLR4 toll-like receptor 4
TMEM100 transmembrane protein 100
TMPO thymopoietin
TMX4 thioredoxin-related transmembrane protein 4
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAPPC3 trafficking protein particle complex 3
TST thiosulfate sulfurtransferase (rhodanese)
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UBL3 ubiquitin-like 3
UMPS uridine monophosphate synthetase
USP1 ubiquitin specific peptidase 1
VCAN versican
WDR6 WD repeat domain 6
WSB1 WD repeat and SOCS box containing 1
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)
ZBED5 zinc finger, BED-type containing 5
ZDHHC6 zinc finger, DHHC-type containing 6
ZMYM2 zinc finger, MYM-type 2