BRD-K19220233_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

259 genes differentially expressed following the BRD-K19220233_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ADD3 adducin 3 (gamma)
ADGRF5 adhesion G protein-coupled receptor F5
ADIRF adipogenesis regulatory factor
AEBP1 AE binding protein 1
ANKRD36B ankyrin repeat domain 36B
ASPN asporin
BSG basigin (Ok blood group)
CA1 carbonic anhydrase I
CA4 carbonic anhydrase IV
CCND2 cyclin D2
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CERS6 ceramide synthase 6
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CNN3 calponin 3, acidic
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
CYBRD1 cytochrome b reductase 1
EFHD1 EF-hand domain family, member D1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENPEP glutamyl aminopeptidase (aminopeptidase A)
FGF13 fibroblast growth factor 13
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GLUD1 glutamate dehydrogenase 1
GNS glucosamine (N-acetyl)-6-sulfatase
GPM6A glycoprotein M6A
GSN gelsolin
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIST1H1C histone cluster 1, H1c
HIST1H2BD histone cluster 1, H2bd
HRSP12 heat-responsive protein 12
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IQGAP1 IQ motif containing GTPase activating protein 1
KIAA0226L KIAA0226-like
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MGP matrix Gla protein
NEBL nebulette
NID2 nidogen 2 (osteonidogen)
NPR3 natriuretic peptide receptor 3
NRP1 neuropilin 1
NT5E 5'-nucleotidase, ecto (CD73)
OLFML2A olfactomedin-like 2A
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PLAGL1 pleiomorphic adenoma gene-like 1
PLAUR plasminogen activator, urokinase receptor
POPDC3 popeye domain containing 3
POSTN periostin, osteoblast specific factor
PRSS3 protease, serine, 3
PSPH phosphoserine phosphatase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKP1 S-phase kinase-associated protein 1
SNX10 sorting nexin 10
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
STC1 stanniocalcin 1
SULF1 sulfatase 1
THBS2 thrombospondin 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPD52L1 tumor protein D52-like 1
TSPAN31 tetraspanin 31
VIM vimentin
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ATMIN ATM interactor
AURKA aurora kinase A
AVPI1 arginine vasopressin-induced 1
BAG3 BCL2-associated athanogene 3
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BCL6 B-cell CLL/lymphoma 6
BLCAP bladder cancer associated protein
BTG1 B-cell translocation gene 1, anti-proliferative
C10ORF2 chromosome 10 open reading frame 2
C14ORF169 chromosome 14 open reading frame 169
C1R complement component 1, r subcomponent
CADM1 cell adhesion molecule 1
CCNA2 cyclin A2
CCNF cyclin F
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDKN2AIP CDKN2A interacting protein
CDR2 cerebellar degeneration-related protein 2, 62kDa
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CENPA centromere protein A
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CKS2 CDC28 protein kinase regulatory subunit 2
COG2 component of oligomeric golgi complex 2
COIL coilin
CSRP1 cysteine and glycine-rich protein 1
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DPT dermatopontin
DUSP6 dual specificity phosphatase 6
DUSP7 dual specificity phosphatase 7
FASTKD5 FAST kinase domains 5
FEM1B fem-1 homolog b (C. elegans)
FEN1 flap structure-specific endonuclease 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GABPB1 GA binding protein transcription factor, beta subunit 1
GAS1 growth arrest-specific 1
GEMIN4 gem (nuclear organelle) associated protein 4
GNAS GNAS complex locus
GPATCH8 G patch domain containing 8
GRWD1 glutamate-rich WD repeat containing 1
GSPT2 G1 to S phase transition 2
GTF2B general transcription factor IIB
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
GTSE1 G-2 and S-phase expressed 1
H2AFX H2A histone family, member X
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFI16 interferon, gamma-inducible protein 16
IGKV1-5 immunoglobulin kappa variable 1-5
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INPP1 inositol polyphosphate-1-phosphatase
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
JCHAIN joining chain of multimeric IgA and IgM
JMJD6 jumonji domain containing 6
KAT6A K(lysine) acetyltransferase 6A
KEAP1 kelch-like ECH-associated protein 1
KIAA0907 KIAA0907
KIF2A kinesin heavy chain member 2A
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LAT2 linker for activation of T cells family, member 2
LCMT2 leucine carboxyl methyltransferase 2
LSG1 large 60S subunit nuclear export GTPase 1
LYZ lysozyme
MAK16 MAK16 homolog (S. cerevisiae)
MARCKS myristoylated alanine-rich protein kinase C substrate
MAT2A methionine adenosyltransferase II, alpha
MECOM MDS1 and EVI1 complex locus
MED17 mediator complex subunit 17
METTL18 methyltransferase like 18
MFSD5 major facilitator superfamily domain containing 5
MRFAP1L1 Morf4 family associated protein 1-like 1
MSANTD2 Myb/SANT-like DNA-binding domain containing 2
MSH6 mutS homolog 6
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NFYA nuclear transcription factor Y, alpha
NGDN neuroguidin, EIF4E binding protein
NKX3-1 NK3 homeobox 1
NOP16 NOP16 nucleolar protein
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1
NUP50 nucleoporin 50kDa
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXN nucleoredoxin
NXT1 nuclear transport factor 2-like export factor 1
PALB2 partner and localizer of BRCA2
PDS5B PDS5 cohesin associated factor B
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
POGK pogo transposable element with KRAB domain
POU2AF1 POU class 2 associating factor 1
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRR7 proline rich 7 (synaptic)
RANBP2 RAN binding protein 2
RANBP6 RAN binding protein 6
RAP2B RAP2B, member of RAS oncogene family
RBM12 RNA binding motif protein 12
RBM14 RNA binding motif protein 14
RBM15 RNA binding motif protein 15
RBM7 RNA binding motif protein 7
RHOB ras homolog family member B
RNF111 ring finger protein 111
RNF219 ring finger protein 219
RPP38 ribonuclease P/MRP 38kDa subunit
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RUNX3 runt-related transcription factor 3
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERTAD2 SERTA domain containing 2
SESN1 sestrin 1
SETD5 SET domain containing 5
SF3B4 splicing factor 3b, subunit 4, 49kDa
SGK1 serum/glucocorticoid regulated kinase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SMAD7 SMAD family member 7
SNRK SNF related kinase
SOX4 SRY (sex determining region Y)-box 4
SPATA2 spermatogenesis associated 2
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SRSF7 serine/arginine-rich splicing factor 7
STK17A serine/threonine kinase 17a
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TEFM transcription elongation factor, mitochondrial
TEX10 testis expressed 10
TFAM transcription factor A, mitochondrial
TGIF1 TGFB-induced factor homeobox 1
THAP11 THAP domain containing 11
THUMPD1 THUMP domain containing 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMPO thymopoietin
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRIM32 tripartite motif containing 32
TSC22D2 TSC22 domain family, member 2
TSKU tsukushi, small leucine rich proteoglycan
TUBA4A tubulin, alpha 4a
UMPS uridine monophosphate synthetase
USP1 ubiquitin specific peptidase 1
UTP3 UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)
WEE1 WEE1 G2 checkpoint kinase
WIPF2 WAS/WASL interacting protein family, member 2
XBP1 X-box binding protein 1
ZBTB1 zinc finger and BTB domain containing 1
ZCCHC2 zinc finger, CCHC domain containing 2
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF202 zinc finger protein 202
ZNF263 zinc finger protein 263
ZNF318 zinc finger protein 318
ZYX zyxin