BRD-K19146323_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K19146323_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCL2A1 BCL2-related protein A1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD9 CD9 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLTC clathrin, heavy chain (Hc)
CRISP3 cysteine-rich secretory protein 3
CXCL11 chemokine (C-X-C motif) ligand 11
EGR1 early growth response 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
IER3 immediate early response 3
IVNS1ABP influenza virus NS1A binding protein
KLF6 Kruppel-like factor 6
LIF leukemia inhibitory factor
LXN latexin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MBNL2 muscleblind-like splicing regulator 2
MBP myelin basic protein
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MT1F metallothionein 1F
MT1X metallothionein 1X
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NR4A1 nuclear receptor subfamily 4, group A, member 1
PDGFA platelet-derived growth factor alpha polypeptide
PHLDA1 pleckstrin homology-like domain, family A, member 1
POSTN periostin, osteoblast specific factor
PPP1R16B protein phosphatase 1, regulatory subunit 16B
PRR7 proline rich 7 (synaptic)
PRSS2 protease, serine, 2 (trypsin 2)
PRSS3 protease, serine, 3
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A11 S100 calcium binding protein A11
S100A6 S100 calcium binding protein A6
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3GLB1 SH3-domain GRB2-like endophilin B1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD3 SMAD family member 3
SPINK1 serine peptidase inhibitor, Kazal type 1
SQSTM1 sequestosome 1
THBS1 thrombospondin 1
TPD52L1 tumor protein D52-like 1
VNN1 vanin 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ASS1 argininosuccinate synthase 1
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BST2 bone marrow stromal cell antigen 2
C7 complement component 7
CASP6 caspase 6, apoptosis-related cysteine peptidase
CCNF cyclin F
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
CRIP1 cysteine-rich protein 1 (intestinal)
CSRP2 cysteine and glycine-rich protein 2
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
DUSP3 dual specificity phosphatase 3
EFNB2 ephrin-B2
FASTKD5 FAST kinase domains 5
FGFR4 fibroblast growth factor receptor 4
FRZB frizzled-related protein
FTSJ2 FtsJ RNA methyltransferase homolog 2 (E. coli)
GAS1 growth arrest-specific 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HEXIM1 hexamethylene bis-acetamide inducible 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOXC6 homeobox C6
HSPA2 heat shock 70kDa protein 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KAZN kazrin, periplakin interacting protein
KIF20A kinesin family member 20A
MAOB monoamine oxidase B
MTDH metadherin
MYBPC1 myosin binding protein C, slow type
NDRG2 NDRG family member 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
PARP2 poly (ADP-ribose) polymerase 2
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PEX11A peroxisomal biogenesis factor 11 alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRKCA protein kinase C, alpha
PRPF4 pre-mRNA processing factor 4
SORD sorbitol dehydrogenase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM47 transmembrane protein 47
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM14 tripartite motif containing 14
TRIM22 tripartite motif containing 22
TUBA4A tubulin, alpha 4a
TXNDC9 thioredoxin domain containing 9