BRD-K18787491_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

73 genes differentially expressed following the BRD-K18787491_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
CCL5 chemokine (C-C motif) ligand 5
CD81 CD81 molecule
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
E2F2 E2F transcription factor 2
FCGBP Fc fragment of IgG binding protein
GALC galactosylceramidase
GPER1 G protein-coupled estrogen receptor 1
HMOX1 heme oxygenase 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MUC5B mucin 5B, oligomeric mucus/gel-forming
PGRMC2 progesterone receptor membrane component 2
PLXNA1 plexin A1
POSTN periostin, osteoblast specific factor
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS1 regulator of G-protein signaling 1
SESN1 sestrin 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BID BH3 interacting domain death agonist
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CEMIP cell migration inducing protein, hyaluronan binding
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
DES desmin
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHA3 EPH receptor A3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
INPP1 inositol polyphosphate-1-phosphatase
INPP5A inositol polyphosphate-5-phosphatase, 40kDa
IPO13 importin 13
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEF2C myocyte enhancer factor 2C
MGP matrix Gla protein
MT1E metallothionein 1E
NPDC1 neural proliferation, differentiation and control, 1
NRIP1 nuclear receptor interacting protein 1
PDLIM5 PDZ and LIM domain 5
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLCB4 phospholipase C, beta 4
RTN1 reticulon 1
S100A12 S100 calcium binding protein A12
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPM2 tropomyosin 2 (beta)
TSC22D1 TSC22 domain family, member 1
TXNDC9 thioredoxin domain containing 9