BRD-K18726304_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K18726304_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANKRD10 ankyrin repeat domain 10
ASPN asporin
ATF5 activating transcription factor 5
BAG3 BCL2-associated athanogene 3
BHLHE41 basic helix-loop-helix family, member e41
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL8 chemokine (C-C motif) ligand 8
CD163 CD163 molecule
CDC14B cell division cycle 14B
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CECR1 cat eye syndrome chromosome region, candidate 1
CLCN3 chloride channel, voltage-sensitive 3
CLDND1 claudin domain containing 1
COL1A1 collagen, type I, alpha 1
CXCL12 chemokine (C-X-C motif) ligand 12
DPYD dihydropyrimidine dehydrogenase
EGR2 early growth response 2
EGR3 early growth response 3
F13A1 coagulation factor XIII, A1 polypeptide
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
GATA3 GATA binding protein 3
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
GOLM1 golgi membrane protein 1
GRB7 growth factor receptor-bound protein 7
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
INPP1 inositol polyphosphate-1-phosphatase
IPO13 importin 13
IRS2 insulin receptor substrate 2
ITM2A integral membrane protein 2A
KLK6 kallikrein-related peptidase 6
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP7 microtubule-associated protein 7
METTL7A methyltransferase like 7A
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
PAN2 PAN2 poly(A) specific ribonuclease subunit
PLXNC1 plexin C1
RBM47 RNA binding motif protein 47
RRAGD Ras-related GTP binding D
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SCPEP1 serine carboxypeptidase 1
SEC14L1 SEC14-like 1 (S. cerevisiae)
ST7 suppression of tumorigenicity 7
TIAM1 T-cell lymphoma invasion and metastasis 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRAF3IP3 TRAF3 interacting protein 3
TSPAN7 tetraspanin 7
VCAN versican

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ANXA3 annexin A3
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ASL argininosuccinate lyase
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AUTS2 autism susceptibility candidate 2
AXIN1 axin 1
AZU1 azurocidin 1
CALD1 caldesmon 1
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CCND1 cyclin D1
CD24 CD24 molecule
CDC42 cell division cycle 42
CDCA4 cell division cycle associated 4
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFLAR CASP8 and FADD-like apoptosis regulator
CHMP6 charged multivesicular body protein 6
CTSG cathepsin G
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DEFA4 defensin, alpha 4, corticostatin
DNM1L dynamin 1-like
ELANE elastase, neutrophil expressed
FRZB frizzled-related protein
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
IL7R interleukin 7 receptor
LPL lipoprotein lipase
LYZ lysozyme
MCAM melanoma cell adhesion molecule
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PRAME preferentially expressed antigen in melanoma
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RBP4 retinol binding protein 4, plasma
SCAND1 SCAN domain containing 1
SDC2 syndecan 2
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SRSF3 serine/arginine-rich splicing factor 3
THBS1 thrombospondin 1
TXNDC9 thioredoxin domain containing 9
ZNF586 zinc finger protein 586