BRD-K18724229_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

299 genes differentially expressed following the BRD-K18724229_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACAA1 acetyl-CoA acyltransferase 1
ACPP acid phosphatase, prostate
ACSL3 acyl-CoA synthetase long-chain family member 3
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANXA3 annexin A3
APLP2 amyloid beta (A4) precursor-like protein 2
APOD apolipoprotein D
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARG2 arginase 2
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BASP1 brain abundant, membrane attached signal protein 1
BMP7 bone morphogenetic protein 7
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CAV2 caveolin 2
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CES1 carboxylesterase 1
CFD complement factor D (adipsin)
CKB creatine kinase, brain
CKM creatine kinase, muscle
CLCA2 chloride channel accessory 2
COL15A1 collagen, type XV, alpha 1
COL4A5 collagen, type IV, alpha 5
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CST3 cystatin C
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DMXL2 Dmx-like 2
DRAM1 DNA-damage regulated autophagy modulator 1
DSP desmoplakin
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EFNB2 ephrin-B2
EPAS1 endothelial PAS domain protein 1
EPHA2 EPH receptor A2
ERBB2 erb-b2 receptor tyrosine kinase 2
FHOD3 formin homology 2 domain containing 3
FLRT3 fibronectin leucine rich transmembrane protein 3
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA2 GATA binding protein 2
GATA6 GATA binding protein 6
GM2A GM2 ganglioside activator
GPR87 G protein-coupled receptor 87
GPX2 glutathione peroxidase 2
GRN granulin
GSN gelsolin
GSTA1 glutathione S-transferase alpha 1
GSTM3 glutathione S-transferase mu 3 (brain)
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPG2 heparan sulfate proteoglycan 2
INHBB inhibin, beta B
IRS2 insulin receptor substrate 2
JAG1 jagged 1
JAG2 jagged 2
KIAA0232 KIAA0232
KRT17 keratin 17, type I
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
LAMB3 laminin, beta 3
LCN2 lipocalin 2
LRP10 low density lipoprotein receptor-related protein 10
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MIR22HG MIR22 host gene
MMP12 matrix metallopeptidase 12
MSMB microseminoprotein, beta-
MYO1B myosin IB
MYO6 myosin VI
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NDRG1 N-myc downstream regulated 1
NEB nebulin
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRCAM neuronal cell adhesion molecule
PDGFA platelet-derived growth factor alpha polypeptide
PERP PERP, TP53 apoptosis effector
PINK1 PTEN induced putative kinase 1
PLAU plasminogen activator, urokinase
PLXNA1 plexin A1
PRSS8 protease, serine, 8
PSAP prosaposin
PTPRE protein tyrosine phosphatase, receptor type, E
RALB v-ral simian leukemia viral oncogene homolog B
RAP1GAP RAP1 GTPase activating protein
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RNF19B ring finger protein 19B
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SESN1 sestrin 1
SIK1 salt-inducible kinase 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SOX9 SRY (sex determining region Y)-box 9
STAT1 signal transducer and activator of transcription 1, 91kDa
STC1 stanniocalcin 1
STOM stomatin
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGFA transforming growth factor, alpha
TIGAR TP53 induced glycolysis regulatory phosphatase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF20 transmembrane 4 L six family member 20
TMEM2 transmembrane protein 2
TRIM29 tripartite motif containing 29
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
YPEL5 yippee-like 5 (Drosophila)
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADSL adenylosuccinate lyase
AKAP7 A kinase (PRKA) anchor protein 7
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BARD1 BRCA1 associated RING domain 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C20ORF27 chromosome 20 open reading frame 27
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD200 CD200 molecule
CDC20 cell division cycle 20
CDCA3 cell division cycle associated 3
CDK1 cyclin-dependent kinase 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CENPN centromere protein N
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL12 chemokine (C-X-C motif) ligand 12
DCK deoxycytidine kinase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EIF5A eukaryotic translation initiation factor 5A
EPRS glutamyl-prolyl-tRNA synthetase
ESD esterase D
ESR1 estrogen receptor 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM64A family with sequence similarity 64, member A
FCGBP Fc fragment of IgG binding protein
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GABPB1 GA binding protein transcription factor, beta subunit 1
GGCT gamma-glutamylcyclotransferase
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTSE1 G-2 and S-phase expressed 1
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H4C histone cluster 1, H4c
HMG20B high mobility group 20B
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICAM3 intercellular adhesion molecule 3
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IPO7 importin 7
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF15 kinesin family member 15
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
KIF4A kinesin family member 4A
KIFC1 kinesin family member C1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAGE3 L antigen family, member 3
LMNB1 lamin B1
LOC100505650 uncharacterized LOC100505650
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM2 minichromosome maintenance complex component 2
MCM5 minichromosome maintenance complex component 5
MCTS1 malignant T cell amplified sequence 1
MELK maternal embryonic leucine zipper kinase
METTL7A methyltransferase like 7A
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MRPL12 mitochondrial ribosomal protein L12
MRPL15 mitochondrial ribosomal protein L15
MTERF3 mitochondrial transcription termination factor 3
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH10 myosin, heavy chain 10, non-muscle
NCAPH non-SMC condensin I complex, subunit H
NEK2 NIMA-related kinase 2
NET1 neuroepithelial cell transforming 1
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPM3 nucleophosmin/nucleoplasmin 3
NUP107 nucleoporin 107kDa
NVL nuclear VCP-like
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PBK PDZ binding kinase
PHGDH phosphoglycerate dehydrogenase
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLK1 polo-like kinase 1
PLSCR4 phospholipid scramblase 4
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR1E polymerase (RNA) I polypeptide E, 53kDa
PRC1 protein regulator of cytokinesis 1
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PROM1 prominin 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PSPH phosphoserine phosphatase
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RACGAP1 Rac GTPase activating protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RNASEH2A ribonuclease H2, subunit A
RPA3 replication protein A3, 14kDa
RRM1 ribonucleotide reductase M1
SDC2 syndecan 2
SEPW1 selenoprotein W, 1
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SPAG5 sperm associated antigen 5
SPC25 SPC25, NDC80 kinetochore complex component
SPON1 spondin 1, extracellular matrix protein
STMN1 stathmin 1
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
TIMELESS timeless circadian clock
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TMEM109 transmembrane protein 109
TMEM126B transmembrane protein 126B
TMEM97 transmembrane protein 97
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
TRA2B transformer 2 beta homolog (Drosophila)
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TTK TTK protein kinase
TUBB tubulin, beta class I
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
VRK1 vaccinia related kinase 1
XBP1 X-box binding protein 1
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein