BRD-K18724229_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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87 genes differentially expressed following the BRD-K18724229_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANKRD10 ankyrin repeat domain 10
ATF5 activating transcription factor 5
C1QB complement component 1, q subcomponent, B chain
CD14 CD14 molecule
CD163 CD163 molecule
CES1 carboxylesterase 1
CSNK2A2 casein kinase 2, alpha prime polypeptide
CTSS cathepsin S
CYFIP1 cytoplasmic FMR1 interacting protein 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
EGR2 early growth response 2
F13A1 coagulation factor XIII, A1 polypeptide
GOLM1 golgi membrane protein 1
GRB14 growth factor receptor-bound protein 14
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP6 insulin-like growth factor binding protein 6
INPP1 inositol polyphosphate-1-phosphatase
KRCC1 lysine-rich coiled-coil 1
KRT5 keratin 5, type II
LAPTM5 lysosomal protein transmembrane 5
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MKNK2 MAP kinase interacting serine/threonine kinase 2
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
NBPF10 neuroblastoma breakpoint family, member 10
NMU neuromedin U
NOTCH1 notch 1
PCCA propionyl CoA carboxylase, alpha polypeptide
PLTP phospholipid transfer protein
RIMS3 regulating synaptic membrane exocytosis 3
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SESN1 sestrin 1
ST7 suppression of tumorigenicity 7
SYT1 synaptotagmin I
TFF3 trefoil factor 3 (intestinal)
TMEM158 transmembrane protein 158 (gene/pseudogene)
VSIG4 V-set and immunoglobulin domain containing 4
WLS wntless Wnt ligand secretion mediator
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
AMDHD2 amidohydrolase domain containing 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BOP1 block of proliferation 1
BST2 bone marrow stromal cell antigen 2
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFD complement factor D (adipsin)
CHMP4A charged multivesicular body protein 4A
CHMP6 charged multivesicular body protein 6
COL1A2 collagen, type I, alpha 2
CXCL5 chemokine (C-X-C motif) ligand 5
DEPTOR DEP domain containing MTOR-interacting protein
DGAT1 diacylglycerol O-acyltransferase 1
ELANE elastase, neutrophil expressed
FGFR4 fibroblast growth factor receptor 4
FN1 fibronectin 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GPC3 glypican 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
MCAM melanoma cell adhesion molecule
MDK midkine (neurite growth-promoting factor 2)
MID1 midline 1
MME membrane metallo-endopeptidase
MRPL12 mitochondrial ribosomal protein L12
MSLN mesothelin
MX1 MX dynamin-like GTPase 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFE2 nuclear factor, erythroid 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
PLA2G16 phospholipase A2, group XVI
RPS11 ribosomal protein S11
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
STC2 stanniocalcin 2
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WSB1 WD repeat and SOCS box containing 1
ZHX2 zinc fingers and homeoboxes 2
ZNF586 zinc finger protein 586