BRD-K18724229_-666_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

136 genes differentially expressed following the BRD-K18724229_-666_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADAM10 ADAM metallopeptidase domain 10
ADGRL2 adhesion G protein-coupled receptor L2
AEBP1 AE binding protein 1
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ASPN asporin
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BAG3 BCL2-associated athanogene 3
BANK1 B-cell scaffold protein with ankyrin repeats 1
C1QTNF3 C1q and tumor necrosis factor related protein 3
CRIP1 cysteine-rich protein 1 (intestinal)
CSRP2 cysteine and glycine-rich protein 2
DCHS1 dachsous cadherin-related 1
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
EMX2 empty spiracles homeobox 2
ESR1 estrogen receptor 1
EZR ezrin
FASTKD5 FAST kinase domains 5
FOLR1 folate receptor 1 (adult)
FOS FBJ murine osteosarcoma viral oncogene homolog
GAS1 growth arrest-specific 1
GOLM1 golgi membrane protein 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IL13RA1 interleukin 13 receptor, alpha 1
INSR insulin receptor
IQGAP2 IQ motif containing GTPase activating protein 2
IRS2 insulin receptor substrate 2
LAMP1 lysosomal-associated membrane protein 1
LAMP5 lysosomal-associated membrane protein family, member 5
LBH limb bud and heart development
LEF1 lymphoid enhancer-binding factor 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP11 matrix metallopeptidase 11
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PAX5 paired box 5
PAX8 paired box 8
PITX1 paired-like homeodomain 1
PLIN2 perilipin 2
PRAME preferentially expressed antigen in melanoma
RASA4 RAS p21 protein activator 4
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS5 regulator of G-protein signaling 5
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STK17A serine/threonine kinase 17a
THSD7A thrombospondin, type I, domain containing 7A
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNS1 tensin 1
TP53 tumor protein p53
TSPAN7 tetraspanin 7
TXNIP thioredoxin interacting protein
ZNF281 zinc finger protein 281

decreased expression

Symbol Name
ACTL6A actin-like 6A
ADIRF adipogenesis regulatory factor
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AREG amphiregulin
ARL4A ADP-ribosylation factor-like 4A
ATF1 activating transcription factor 1
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
BTG1 B-cell translocation gene 1, anti-proliferative
C2CD5 C2 calcium-dependent domain containing 5
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CCNB2 cyclin B2
CDCA4 cell division cycle associated 4
CFD complement factor D (adipsin)
CFH complement factor H
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC7A C-type lectin domain family 7, member A
CPA3 carboxypeptidase A3 (mast cell)
CRYM crystallin, mu
CXCL2 chemokine (C-X-C motif) ligand 2
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DMBT1 deleted in malignant brain tumors 1
DOCK4 dedicator of cytokinesis 4
ECT2 epithelial cell transforming 2
EGFR epidermal growth factor receptor
EIF1AX eukaryotic translation initiation factor 1A, X-linked
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GMNN geminin, DNA replication inhibitor
GNPTAB N-acetylglucosamine-1-phosphate transferase, alpha and beta subunits
GPRC5B G protein-coupled receptor, class C, group 5, member B
HOXA5 homeobox A5
IFIH1 interferon induced with helicase C domain 1
IL1R1 interleukin 1 receptor, type I
IRS1 insulin receptor substrate 1
JCHAIN joining chain of multimeric IgA and IgM
KIAA0125 KIAA0125
KLF5 Kruppel-like factor 5 (intestinal)
KRAS Kirsten rat sarcoma viral oncogene homolog
KYNU kynureninase
LAMP3 lysosomal-associated membrane protein 3
LUM lumican
MYC v-myc avian myelocytomatosis viral oncogene homolog
N4BP2L2 NEDD4 binding protein 2-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOTCH2NL notch 2 N-terminal like
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUP62 nucleoporin 62kDa
OLFM4 olfactomedin 4
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PDE4C phosphodiesterase 4C, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLK2 polo-like kinase 2
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
PRDX4 peroxiredoxin 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS1 regulator of G-protein signaling 1
RRM2 ribonucleotide reductase M2
SCYL3 SCY1-like 3 (S. cerevisiae)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFPI2 tissue factor pathway inhibitor 2
TFRC transferrin receptor
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TM4SF1 transmembrane 4 L six family member 1
VCAM1 vascular cell adhesion molecule 1
ZNF160 zinc finger protein 160
ZNF721 zinc finger protein 721