BRD-K18724229_-666_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-K18724229_-666_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACTG2 actin, gamma 2, smooth muscle, enteric
ADGRF5 adhesion G protein-coupled receptor F5
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ANKRD10 ankyrin repeat domain 10
APLP2 amyloid beta (A4) precursor-like protein 2
APOC1 apolipoprotein C-I
ARG2 arginase 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARID4B AT rich interactive domain 4B (RBP1-like)
ASPN asporin
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BCL6 B-cell CLL/lymphoma 6
BTG2 BTG family, member 2
C3 complement component 3
C3ORF14 chromosome 3 open reading frame 14
CCDC28A coiled-coil domain containing 28A
CCND2 cyclin D2
CD200 CD200 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLU clusterin
CP ceruloplasmin (ferroxidase)
CPE carboxypeptidase E
CSNK2A2 casein kinase 2, alpha prime polypeptide
CXCL13 chemokine (C-X-C motif) ligand 13
DACH1 dachshund family transcription factor 1
DCHS1 dachsous cadherin-related 1
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
DUSP6 dual specificity phosphatase 6
ELOVL5 ELOVL fatty acid elongase 5
EPS8 epidermal growth factor receptor pathway substrate 8
FILIP1L filamin A interacting protein 1-like
FRY furry homolog (Drosophila)
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
GSTA1 glutathione S-transferase alpha 1
HECA headcase homolog (Drosophila)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
INHBB inhibin, beta B
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KCTD12 potassium channel tetramerization domain containing 12
KRT23 keratin 23, type I
LAMP3 lysosomal-associated membrane protein 3
LGALS8 lectin, galactoside-binding, soluble, 8
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAOB monoamine oxidase B
MGP matrix Gla protein
MMP12 matrix metallopeptidase 12
MSMO1 methylsterol monooxygenase 1
MTUS1 microtubule associated tumor suppressor 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYO6 myosin VI
NID1 nidogen 1
NPTX2 neuronal pentraxin II
NR4A2 nuclear receptor subfamily 4, group A, member 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PCP4 Purkinje cell protein 4
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRNP prion protein
PTN pleiotrophin
PTPRE protein tyrosine phosphatase, receptor type, E
QPCT glutaminyl-peptide cyclotransferase
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RGS16 regulator of G-protein signaling 16
RGS2 regulator of G-protein signaling 2
RNF103 ring finger protein 103
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SGK1 serum/glucocorticoid regulated kinase 1
SORBS1 sorbin and SH3 domain containing 1
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STK38L serine/threonine kinase 38 like
STON1 stonin 1
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TBPL1 TBP-like 1
TDO2 tryptophan 2,3-dioxygenase
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM176B transmembrane protein 176B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOX3 TOX high mobility group box family member 3
TSPAN12 tetraspanin 12
TUBB2B tubulin, beta 2B class IIb
TXNIP thioredoxin interacting protein
WLS wntless Wnt ligand secretion mediator
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZBTB18 zinc finger and BTB domain containing 18
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AHNAK AHNAK nucleoprotein
AMDHD2 amidohydrolase domain containing 2
ANPEP alanyl (membrane) aminopeptidase
ARPP19 cAMP-regulated phosphoprotein, 19kDa
BIN1 bridging integrator 1
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
CCND1 cyclin D1
CDCA4 cell division cycle associated 4
CFLAR CASP8 and FADD-like apoptosis regulator
CHMP6 charged multivesicular body protein 6
COL1A1 collagen, type I, alpha 1
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EPHB2 EPH receptor B2
ERBB2 erb-b2 receptor tyrosine kinase 2
ESD esterase D
EZR ezrin
FLNA filamin A, alpha
FNBP1 formin binding protein 1
FOSL1 FOS-like antigen 1
FOXD1 forkhead box D1
FPGS folylpolyglutamate synthase
GABPB1 GA binding protein transcription factor, beta subunit 1
GLDC glycine dehydrogenase (decarboxylating)
GLIPR1 GLI pathogenesis-related 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
H1FX H1 histone family, member X
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HOXA10 homeobox A10
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSPA8 heat shock 70kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IQGAP1 IQ motif containing GTPase activating protein 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLC1 kinesin light chain 1
KLF2 Kruppel-like factor 2
KLF6 Kruppel-like factor 6
LOX lysyl oxidase
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MAT2A methionine adenosyltransferase II, alpha
MOK MOK protein kinase
MRPL12 mitochondrial ribosomal protein L12
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOV nephroblastoma overexpressed
PAX8 paired box 8
PFKL phosphofructokinase, liver
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLEC plectin
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRR16 proline rich 16
PTX3 pentraxin 3, long
QDPR quinoid dihydropteridine reductase
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS4 regulator of G-protein signaling 4
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
SET SET nuclear proto-oncogene
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNAI2 snail family zinc finger 2
SORBS3 sorbin and SH3 domain containing 3
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SRSF5 serine/arginine-rich splicing factor 5
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TUBB tubulin, beta class I
U2AF1 U2 small nuclear RNA auxiliary factor 1