BRD-K18724229_-666_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K18724229_-666_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABHD4 abhydrolase domain containing 4
ADD3 adducin 3 (gamma)
ADIPOQ adiponectin, C1Q and collagen domain containing
AIM1 absent in melanoma 1
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOB aldolase B, fructose-bisphosphate
ANPEP alanyl (membrane) aminopeptidase
APLP2 amyloid beta (A4) precursor-like protein 2
AREG amphiregulin
ATP10D ATPase, class V, type 10D
BLNK B-cell linker
BTG3 BTG family, member 3
CCND2 cyclin D2
CCNG1 cyclin G1
CCP110 centriolar coiled coil protein 110kDa
CD36 CD36 molecule (thrombospondin receptor)
CD93 CD93 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
CKM creatine kinase, muscle
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSRP2 cysteine and glycine-rich protein 2
DCHS1 dachsous cadherin-related 1
DCN decorin
DDB2 damage-specific DNA binding protein 2, 48kDa
DEPTOR DEP domain containing MTOR-interacting protein
DUSP6 dual specificity phosphatase 6
FABP4 fatty acid binding protein 4, adipocyte
FAS Fas cell surface death receptor
FBLN1 fibulin 1
FBXL12 F-box and leucine-rich repeat protein 12
FDX1 ferredoxin 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FLRT3 fibronectin leucine rich transmembrane protein 3
FN1 fibronectin 1
FOLR1 folate receptor 1 (adult)
FZD7 frizzled class receptor 7
G0S2 G0/G1 switch 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GSN gelsolin
HES1 hes family bHLH transcription factor 1
HSBP1 heat shock factor binding protein 1
HSDL2 hydroxysteroid dehydrogenase like 2
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
KCTD12 potassium channel tetramerization domain containing 12
KLF11 Kruppel-like factor 11
KRT14 keratin 14, type I
KRT5 keratin 5, type II
LAMB1 laminin, beta 1
LDB3 LIM domain binding 3
LIMA1 LIM domain and actin binding 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MTUS1 microtubule associated tumor suppressor 1
MYO6 myosin VI
NAP1L1 nucleosome assembly protein 1-like 1
NFIB nuclear factor I/B
NXN nucleoredoxin
PBX3 pre-B-cell leukemia homeobox 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PEG3 paternally expressed 3
PELI1 pellino E3 ubiquitin protein ligase 1
PLS1 plastin 1
PLXNB2 plexin B2
PNMAL1 paraneoplastic Ma antigen family-like 1
PTGIS prostaglandin I2 (prostacyclin) synthase
RPS27L ribosomal protein S27-like
SC5D sterol-C5-desaturase
SCARB2 scavenger receptor class B, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6
SESN1 sestrin 1
SFRP1 secreted frizzled-related protein 1
SGCE sarcoglycan, epsilon
SH3GLB1 SH3-domain GRB2-like endophilin B1
SRPX sushi-repeat containing protein, X-linked
STS steroid sulfatase (microsomal), isozyme S
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIGAR TP53 induced glycolysis regulatory phosphatase
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TKTL1 transketolase-like 1
TMPRSS2 transmembrane protease, serine 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TOB1 transducer of ERBB2, 1
TUBB2A tubulin, beta 2A class IIa
XIST X inactive specific transcript (non-protein coding)
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
AKR1C1 aldo-keto reductase family 1, member C1
AMDHD2 amidohydrolase domain containing 2
AUTS2 autism susceptibility candidate 2
CCL2 chemokine (C-C motif) ligand 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFI complement factor I
CHI3L2 chitinase 3-like 2
CHMP4A charged multivesicular body protein 4A
COMP cartilage oligomeric matrix protein
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4A1 eukaryotic translation initiation factor 4A1
EMG1 EMG1 N1-specific pseudouridine methyltransferase
ENO1 enolase 1, (alpha)
EPHB2 EPH receptor B2
FBXO11 F-box protein 11
FKBP11 FK506 binding protein 11, 19 kDa
GABPB1 GA binding protein transcription factor, beta subunit 1
GCLM glutamate-cysteine ligase, modifier subunit
HN1L hematological and neurological expressed 1-like
IGHD immunoglobulin heavy constant delta
IGL immunoglobulin lambda locus
IGLV2-23 immunoglobulin lambda variable 2-23
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KDM5D lysine (K)-specific demethylase 5D
KRT19 keratin 19, type I
LOC100505650 uncharacterized LOC100505650
LPCAT1 lysophosphatidylcholine acyltransferase 1
LYZ lysozyme
MLPH melanophilin
MRPS30 mitochondrial ribosomal protein S30
MSX1 msh homeobox 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NUP62 nucleoporin 62kDa
PCSK1 proprotein convertase subtilisin/kexin type 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POU2AF1 POU class 2 associating factor 1
PUS7 pseudouridylate synthase 7 (putative)
RNASET2 ribonuclease T2
RPIA ribose 5-phosphate isomerase A
RPS4Y1 ribosomal protein S4, Y-linked 1
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
STC2 stanniocalcin 2
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM14A transmembrane protein 14A
TRIP13 thyroid hormone receptor interactor 13
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)