BRD-K18595892_1-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-N-[2-(dipropylamino)ethyl]piperidine-4-carboxamide_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

34 genes differentially expressed following the BRD-K18595892_1-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-N-[2-(dipropylamino)ethyl]piperidine-4-carboxamide_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
ACLY ATP citrate lyase
ACSL3 acyl-CoA synthetase long-chain family member 3
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MSMO1 methylsterol monooxygenase 1
NPC1 Niemann-Pick disease, type C1
NSDHL NAD(P) dependent steroid dehydrogenase-like
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SQLE squalene epoxidase
TMEM97 transmembrane protein 97

decreased expression

Symbol Name
APOD apolipoprotein D
CRYAB crystallin, alpha B
GSTM3 glutathione S-transferase mu 3 (brain)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGDS prostaglandin D2 synthase 21kDa (brain)
S100A8 S100 calcium binding protein A8
TPD52L1 tumor protein D52-like 1