BRD-K18595892_1-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-N-[2-(dipropylamino)ethyl]piperidine-4-carboxamide_HT29_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K18595892_1-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-N-[2-(dipropylamino)ethyl]piperidine-4-carboxamide_HT29_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDOC aldolase C, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX6 armadillo repeat containing, X-linked 6
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPH aspartate beta-hydroxylase
BTG2 BTG family, member 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CPA3 carboxypeptidase A3 (mast cell)
DCLK1 doublecortin-like kinase 1
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
ERBB3 erb-b2 receptor tyrosine kinase 3
FADS1 fatty acid desaturase 1
FKBP11 FK506 binding protein 11, 19 kDa
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
GLRX glutaredoxin (thioltransferase)
GPX2 glutathione peroxidase 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFI27 interferon, alpha-inducible protein 27
INSIG1 insulin induced gene 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
KRT20 keratin 20, type I
LDLR low density lipoprotein receptor
LMNA lamin A/C
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MSMO1 methylsterol monooxygenase 1
NUCB2 nucleobindin 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PHGDH phosphoglycerate dehydrogenase
PSD3 pleckstrin and Sec7 domain containing 3
RAB40B RAB40B, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC4 syndecan 4
SEC24D SEC24 family member D
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC44A4 solute carrier family 44, member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SQLE squalene epoxidase
SQSTM1 sequestosome 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TOX3 TOX high mobility group box family member 3
TRIM2 tripartite motif containing 2
TTC3 tetratricopeptide repeat domain 3
UGDH UDP-glucose 6-dehydrogenase
WIPI1 WD repeat domain, phosphoinositide interacting 1

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANGPT1 angiopoietin 1
CASP1 caspase 1, apoptosis-related cysteine peptidase
CDC25A cell division cycle 25A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL12 chemokine (C-X-C motif) ligand 12
DPYD dihydropyrimidine dehydrogenase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXC6 homeobox C6
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IL13RA2 interleukin 13 receptor, alpha 2
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCDH7 protocadherin 7
PER3 period circadian clock 3
POSTN periostin, osteoblast specific factor
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPRY2 sprouty homolog 2 (Drosophila)
SRSF1 serine/arginine-rich splicing factor 1
SRSF6 serine/arginine-rich splicing factor 6
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
YBX3 Y box binding protein 3