BRD-K18595892_1-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-N-[2-(dipropylamino)ethyl]piperidine-4-carboxamide_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

126 genes differentially expressed following the BRD-K18595892_1-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-N-[2-(dipropylamino)ethyl]piperidine-4-carboxamide_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ALDOC aldolase C, fructose-bisphosphate
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
C14ORF1 chromosome 14 open reading frame 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETV1 ets variant 1
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FBN2 fibrillin 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FXYD2 FXYD domain containing ion transport regulator 2
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDI1 isopentenyl-diphosphate delta isomerase 1
IDS iduronate 2-sulfatase
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NEU1 sialidase 1 (lysosomal sialidase)
NOV nephroblastoma overexpressed
NPC1 Niemann-Pick disease, type C1
NRGN neurogranin (protein kinase C substrate, RC3)
NSDHL NAD(P) dependent steroid dehydrogenase-like
PDE2A phosphodiesterase 2A, cGMP-stimulated
PENK proenkephalin
PSD3 pleckstrin and Sec7 domain containing 3
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A8 S100 calcium binding protein A8
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SDC1 syndecan 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SQSTM1 sequestosome 1
STAP2 signal transducing adaptor family member 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
STXBP1 syntaxin binding protein 1
TECR trans-2,3-enoyl-CoA reductase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TM7SF2 transmembrane 7 superfamily member 2
TMEM97 transmembrane protein 97
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
TSC22D1 TSC22 domain family, member 1
TSC22D3 TSC22 domain family, member 3
TYRP1 tyrosinase-related protein 1
VAT1 vesicle amine transport 1
WBP2 WW domain binding protein 2

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAM19 ADAM metallopeptidase domain 19
AKAP12 A kinase (PRKA) anchor protein 12
ANXA1 annexin A1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CDC42 cell division cycle 42
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DUOX2 dual oxidase 2
EDN1 endothelin 1
EPB41L3 erythrocyte membrane protein band 4.1-like 3
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM46A family with sequence similarity 46, member A
FBP1 fructose-1,6-bisphosphatase 1
FERMT2 fermitin family member 2
GBP1 guanylate binding protein 1, interferon-inducible
GPRC5A G protein-coupled receptor, class C, group 5, member A
HES1 hes family bHLH transcription factor 1
HSPB8 heat shock 22kDa protein 8
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ISG15 ISG15 ubiquitin-like modifier
JCHAIN joining chain of multimeric IgA and IgM
KANK1 KN motif and ankyrin repeat domains 1
LOX lysyl oxidase
MINA MYC induced nuclear antigen
MX1 MX dynamin-like GTPase 1
MXRA5 matrix-remodelling associated 5
NELL2 NEL-like 2 (chicken)
PALLD palladin, cytoskeletal associated protein
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PHACTR2 phosphatase and actin regulator 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RAB25 RAB25, member RAS oncogene family
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SAMD4A sterile alpha motif domain containing 4A
SELL selectin L
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
STC2 stanniocalcin 2
TFF1 trefoil factor 1
TFPI2 tissue factor pathway inhibitor 2
WWP1 WW domain containing E3 ubiquitin protein ligase 1
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon