BRD-K18595892_1-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-N-[2-(dipropylamino)ethyl]piperidine-4-carboxamide_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

97 genes differentially expressed following the BRD-K18595892_1-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-N-[2-(dipropylamino)ethyl]piperidine-4-carboxamide_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD2 abhydrolase domain containing 2
ALB albumin
ANKMY2 ankyrin repeat and MYND domain containing 2
APOE apolipoprotein E
ASS1 argininosuccinate synthase 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BACE2 beta-site APP-cleaving enzyme 2
BZW2 basic leucine zipper and W2 domains 2
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD52 CD52 molecule
CD9 CD9 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CES1 carboxylesterase 1
CETN2 centrin, EF-hand protein, 2
CLGN calmegin
CXCL5 chemokine (C-X-C motif) ligand 5
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR7 7-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
ELOVL6 ELOVL fatty acid elongase 6
EPN2 epsin 2
FADS1 fatty acid desaturase 1
FDPS farnesyl diphosphate synthase
FGFR2 fibroblast growth factor receptor 2
GTF3A general transcription factor IIIA
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IL10RA interleukin 10 receptor, alpha
INSIG1 insulin induced gene 1
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA1033 KIAA1033
KRT19 keratin 19, type I
LDLR low density lipoprotein receptor
LMO4 LIM domain only 4
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
MDK midkine (neurite growth-promoting factor 2)
MLF1 myeloid leukemia factor 1
MSLN mesothelin
MSMB microseminoprotein, beta-
MSMO1 methylsterol monooxygenase 1
NEU1 sialidase 1 (lysosomal sialidase)
NGRN neugrin, neurite outgrowth associated
NSDHL NAD(P) dependent steroid dehydrogenase-like
PCNA proliferating cell nuclear antigen
PDGFC platelet derived growth factor C
PDIA5 protein disulfide isomerase family A, member 5
PHYH phytanoyl-CoA 2-hydroxylase
PTPRC protein tyrosine phosphatase, receptor type, C
RAP1GAP RAP1 GTPase activating protein
REG1A regenerating islet-derived 1 alpha
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SQLE squalene epoxidase
XYLT1 xylosyltransferase I

decreased expression

Symbol Name
BST2 bone marrow stromal cell antigen 2
CCL2 chemokine (C-C motif) ligand 2
CCNF cyclin F
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CXCL14 chemokine (C-X-C motif) ligand 14
DAPK1 death-associated protein kinase 1
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FRZB frizzled-related protein
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
HES1 hes family bHLH transcription factor 1
HSPA2 heat shock 70kDa protein 2
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL1R2 interleukin 1 receptor, type II
KIAA0485 uncharacterized LOC57235
KRT17 keratin 17, type I
LAPTM4B lysosomal protein transmembrane 4 beta
MX2 MX dynamin-like GTPase 2
NEFL neurofilament, light polypeptide
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PGAM1 phosphoglycerate mutase 1 (brain)
PHACTR2 phosphatase and actin regulator 2
PLAC8 placenta-specific 8
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGS1 regulator of G-protein signaling 1
S100A7 S100 calcium binding protein A7
SPTBN1 spectrin, beta, non-erythrocytic 1
SYPL1 synaptophysin-like 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TRIM14 tripartite motif containing 14