BRD-K18595892_1-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-N-[2-(dipropylamino)ethyl]piperidine-4-carboxamide_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

137 genes differentially expressed following the BRD-K18595892_1-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-N-[2-(dipropylamino)ethyl]piperidine-4-carboxamide_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDOC aldolase C, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
CALCA calcitonin-related polypeptide alpha
CD302 CD302 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CFH complement factor H
CLIC2 chloride intracellular channel 2
CPVL carboxypeptidase, vitellogenic-like
CTSZ cathepsin Z
DACT1 dishevelled-binding antagonist of beta-catenin 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
FABP7 fatty acid binding protein 7, brain
FADS1 fatty acid desaturase 1
FAM13A family with sequence similarity 13, member A
FAM46A family with sequence similarity 46, member A
FAR2 fatty acyl CoA reductase 2
FBN1 fibrillin 1
FOLR1 folate receptor 1 (adult)
FOXD1 forkhead box D1
FZD7 frizzled class receptor 7
HEPH hephaestin
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOXC6 homeobox C6
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM1 interferon induced transmembrane protein 1
IGHM immunoglobulin heavy constant mu
IGKV3-20 immunoglobulin kappa variable 3-20
IGL immunoglobulin lambda locus
IKZF1 IKAROS family zinc finger 1 (Ikaros)
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KRT14 keratin 14, type I
LDLR low density lipoprotein receptor
LEPR leptin receptor
LINC00341 long intergenic non-protein coding RNA 341
LPL lipoprotein lipase
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP2K5 mitogen-activated protein kinase kinase 5
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGP matrix Gla protein
MSMO1 methylsterol monooxygenase 1
MTF2 metal response element binding transcription factor 2
MXI1 MAX interactor 1, dimerization protein
NEFL neurofilament, light polypeptide
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NGRN neugrin, neurite outgrowth associated
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
PDGFRL platelet-derived growth factor receptor-like
PHYH phytanoyl-CoA 2-hydroxylase
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RRAGD Ras-related GTP binding D
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SLA Src-like-adaptor
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SPON1 spondin 1, extracellular matrix protein
SQLE squalene epoxidase
SRPX sushi-repeat containing protein, X-linked
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TXNL1 thioredoxin-like 1
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
VSIG4 V-set and immunoglobulin domain containing 4
WDR7 WD repeat domain 7

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADAM9 ADAM metallopeptidase domain 9
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA3 annexin A3
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
C1ORF106 chromosome 1 open reading frame 106
CD24 CD24 molecule
CD9 CD9 molecule
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLCA4 chloride channel accessory 4
COL4A5 collagen, type IV, alpha 5
COL9A2 collagen, type IX, alpha 2
COPS7A COP9 signalosome subunit 7A
CTNND1 catenin (cadherin-associated protein), delta 1
CXADR coxsackie virus and adenovirus receptor
CYR61 cysteine-rich, angiogenic inducer, 61
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
EXT1 exostosin glycosyltransferase 1
FCHO1 FCH domain only 1
FGFR3 fibroblast growth factor receptor 3
FLNA filamin A, alpha
FOXF2 forkhead box F2
FXYD3 FXYD domain containing ion transport regulator 3
GPRC5A G protein-coupled receptor, class C, group 5, member A
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IL1RN interleukin 1 receptor antagonist
KAZN kazrin, periplakin interacting protein
KRT13 keratin 13, type I
KRT7 keratin 7, type II
LAMP1 lysosomal-associated membrane protein 1
MLF2 myeloid leukemia factor 2
MYH10 myosin, heavy chain 10, non-muscle
PALLD palladin, cytoskeletal associated protein
PDIA3 protein disulfide isomerase family A, member 3
PLAC8 placenta-specific 8
PLXNB2 plexin B2
POU2AF1 POU class 2 associating factor 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RNF167 ring finger protein 167
S100P S100 calcium binding protein P
SCGB2A1 secretoglobin, family 2A, member 1
SDC1 syndecan 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TACSTD2 tumor-associated calcium signal transducer 2
TMPRSS2 transmembrane protease, serine 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM4 tropomyosin 4
TUFT1 tuftelin 1
WDR1 WD repeat domain 1
ZNF185 zinc finger protein 185 (LIM domain)