BRD-K18595892_1-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-N-[2-(dipropylamino)ethyl]piperidine-4-carboxamide_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

112 genes differentially expressed following the BRD-K18595892_1-{[2-(4-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]methyl}-N-[2-(dipropylamino)ethyl]piperidine-4-carboxamide_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ACSL3 acyl-CoA synthetase long-chain family member 3
AHNAK2 AHNAK nucleoprotein 2
ALDOC aldolase C, fructose-bisphosphate
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APP amyloid beta (A4) precursor protein
BZW2 basic leucine zipper and W2 domains 2
C14ORF1 chromosome 14 open reading frame 1
C3 complement component 3
CD46 CD46 molecule, complement regulatory protein
CLIC3 chloride intracellular channel 3
CTSK cathepsin K
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FASN fatty acid synthase
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FN1 fibronectin 1
FST follistatin
G6PD glucose-6-phosphate dehydrogenase
GNPDA1 glucosamine-6-phosphate deaminase 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
INSIG1 insulin induced gene 1
LDLR low density lipoprotein receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAGEA1 melanoma antigen family A1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MMP11 matrix metallopeptidase 11
MSMO1 methylsterol monooxygenase 1
MVD mevalonate (diphospho) decarboxylase
MVK mevalonate kinase
MVP major vault protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEU1 sialidase 1 (lysosomal sialidase)
NOTCH2NL notch 2 N-terminal like
NQO1 NAD(P)H dehydrogenase, quinone 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PAM peptidylglycine alpha-amidating monooxygenase
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PHYH phytanoyl-CoA 2-hydroxylase
PNPLA3 patatin-like phospholipase domain containing 3
QPRT quinolinate phosphoribosyltransferase
RDH11 retinol dehydrogenase 11 (all-trans/9-cis/11-cis)
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RRAGD Ras-related GTP binding D
SC5D sterol-C5-desaturase
SCARB1 scavenger receptor class B, member 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCG5 secretogranin V
SFXN3 sideroflexin 3
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SREBF2 sterol regulatory element binding transcription factor 2
TFRC transferrin receptor
TM7SF2 transmembrane 7 superfamily member 2
TUBA1A tubulin, alpha 1a
TUBA4A tubulin, alpha 4a
TUG1 taurine up-regulated 1 (non-protein coding)
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZBED2 zinc finger, BED-type containing 2

decreased expression

Symbol Name
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ASRGL1 asparaginase like 1
BOP1 block of proliferation 1
CA2 carbonic anhydrase II
CD99 CD99 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
COL3A1 collagen, type III, alpha 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSTA cystatin A (stefin A)
CYC1 cytochrome c-1
E2F2 E2F transcription factor 2
ELANE elastase, neutrophil expressed
FGF2 fibroblast growth factor 2 (basic)
HBB hemoglobin, beta
HOXB7 homeobox B7
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
KRT17 keratin 17, type I
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MPPED2 metallophosphoesterase domain containing 2
MSH6 mutS homolog 6
PGAM1 phosphoglycerate mutase 1 (brain)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAGL1 pleiomorphic adenoma gene-like 1
RCAN1 regulator of calcineurin 1
SRGN serglycin
SRP72 signal recognition particle 72kDa