BRD-K18163752_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-K18163752_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BHLHE40 basic helix-loop-helix family, member e40
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
CALB1 calbindin 1, 28kDa
CCNL1 cyclin L1
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHIC2 cysteine-rich hydrophobic domain 2
CHN2 chimerin 2
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EREG epiregulin
ETNK1 ethanolamine kinase 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAM60A family with sequence similarity 60, member A
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FOSL2 FOS-like antigen 2
FOXO3 forkhead box O3
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
GSE1 Gse1 coiled-coil protein
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM5D lysine (K)-specific demethylase 5D
KLF10 Kruppel-like factor 10
KLF2 Kruppel-like factor 2
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KRT14 keratin 14, type I
KRT6B keratin 6B, type II
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LDLR low density lipoprotein receptor
LTBP3 latent transforming growth factor beta binding protein 3
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MED1 mediator complex subunit 1
MSH6 mutS homolog 6
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAV3 neuron navigator 3
NCK1 NCK adaptor protein 1
NDRG1 N-myc downstream regulated 1
NFE2L2 nuclear factor, erythroid 2-like 2
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
PAPOLA poly(A) polymerase alpha
PDLIM5 PDZ and LIM domain 5
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNKP polynucleotide kinase 3'-phosphatase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RCAN1 regulator of calcineurin 1
RHOB ras homolog family member B
RIOK3 RIO kinase 3
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
SYT1 synaptotagmin I
TACSTD2 tumor-associated calcium signal transducer 2
TFF3 trefoil factor 3 (intestinal)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLR4 toll-like receptor 4
TMEM176B transmembrane protein 176B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
UBQLN2 ubiquilin 2
VEGFA vascular endothelial growth factor A
ZEB2 zinc finger E-box binding homeobox 2
ZFAND5 zinc finger, AN1-type domain 5
ZFP36 ZFP36 ring finger protein
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ANOS1 anosmin 1
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
C14ORF132 chromosome 14 open reading frame 132
CA2 carbonic anhydrase II
CALU calumenin
CCNB1 cyclin B1
CDC25A cell division cycle 25A
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
GAL galanin/GMAP prepropeptide
GJA1 gap junction protein, alpha 1, 43kDa
IGHM immunoglobulin heavy constant mu
JCHAIN joining chain of multimeric IgA and IgM
KIF20A kinesin family member 20A
LBR lamin B receptor
MAT2A methionine adenosyltransferase II, alpha
MME membrane metallo-endopeptidase
MYH10 myosin, heavy chain 10, non-muscle
NR2F6 nuclear receptor subfamily 2, group F, member 6
NT5DC2 5'-nucleotidase domain containing 2
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PNISR PNN-interacting serine/arginine-rich protein
PON3 paraoxonase 3
POU2AF1 POU class 2 associating factor 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PXDN peroxidasin
RBM8A RNA binding motif protein 8A
RRM2 ribonucleotide reductase M2
SOX11 SRY (sex determining region Y)-box 11
SST somatostatin
STARD7 StAR-related lipid transfer (START) domain containing 7
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TARDBP TAR DNA binding protein
TCF4 transcription factor 4
TIMP3 TIMP metallopeptidase inhibitor 3
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRAK2 trafficking protein, kinesin binding 2
TSPAN12 tetraspanin 12
TSPAN13 tetraspanin 13