BRD-K18059238_GAMMA-LINOLENIC ACID (18:3 n-6)_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

186 genes differentially expressed following the BRD-K18059238_GAMMA-LINOLENIC ACID (18:3 n-6)_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ADM adrenomedullin
AIM1 absent in melanoma 1
ALOX5 arachidonate 5-lipoxygenase
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCR2 chemokine (C-C motif) receptor 2
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD86 CD86 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH3 cadherin 3, type 1, P-cadherin (placental)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
COL1A2 collagen, type I, alpha 2
CPQ carboxypeptidase Q
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSTA cystatin A (stefin A)
CTSS cathepsin S
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DLK1 delta-like 1 homolog (Drosophila)
DPYD dihydropyrimidine dehydrogenase
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
FAM129A family with sequence similarity 129, member A
FAM69A family with sequence similarity 69, member A
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FHL1 four and a half LIM domains 1
FHOD3 formin homology 2 domain containing 3
FRY furry homolog (Drosophila)
FZD1 frizzled class receptor 1
GALC galactosylceramidase
GATA3 GATA binding protein 3
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
H2AFV H2A histone family, member V
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI16 interferon, gamma-inducible protein 16
IGL immunoglobulin lambda locus
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
JUN jun proto-oncogene
KCTD14 potassium channel tetramerization domain containing 14
LPAR6 lysophosphatidic acid receptor 6
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEF2C myocyte enhancer factor 2C
MME membrane metallo-endopeptidase
MNDA myeloid cell nuclear differentiation antigen
MPZL2 myelin protein zero-like 2
MSMB microseminoprotein, beta-
NCAM1 neural cell adhesion molecule 1
NCF2 neutrophil cytosolic factor 2
NEB nebulin
NELL2 NEL-like 2 (chicken)
NFE2L3 nuclear factor, erythroid 2-like 3
NID1 nidogen 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOX4 NADPH oxidase 4
OPN3 opsin 3
P3H2 prolyl 3-hydroxylase 2
PCP4 Purkinje cell protein 4
PDE4B phosphodiesterase 4B, cAMP-specific
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PLXNC1 plexin C1
PON3 paraoxonase 3
POSTN periostin, osteoblast specific factor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRR15L proline rich 15-like
PTPRO protein tyrosine phosphatase, receptor type, O
PXN paxillin
QPCT glutaminyl-peptide cyclotransferase
RAB27A RAB27A, member RAS oncogene family
RAB38 RAB38, member RAS oncogene family
RAD51AP1 RAD51 associated protein 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNASE6 ribonuclease, RNase A family, k6
RNH1 ribonuclease/angiogenin inhibitor 1
S100A8 S100 calcium binding protein A8
SDC1 syndecan 1
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SOCS2 suppressor of cytokine signaling 2
SOX11 SRY (sex determining region Y)-box 11
SULF1 sulfatase 1
SUSD4 sushi domain containing 4
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TGFA transforming growth factor, alpha
TMEM30B transmembrane protein 30B
TMEM35 transmembrane protein 35
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TRIM2 tripartite motif containing 2
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZNF274 zinc finger protein 274

decreased expression

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ACLY ATP citrate lyase
ADIRF adipogenesis regulatory factor
AGR2 anterior gradient 2
ALDH18A1 aldehyde dehydrogenase 18 family, member A1
ANXA5 annexin A5
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BST2 bone marrow stromal cell antigen 2
CALD1 caldesmon 1
CCL19 chemokine (C-C motif) ligand 19
CD81 CD81 molecule
CD99 CD99 molecule
CDC20 cell division cycle 20
CDKN3 cyclin-dependent kinase inhibitor 3
COMP cartilage oligomeric matrix protein
CTSG cathepsin G
CXCL14 chemokine (C-X-C motif) ligand 14
CYFIP2 cytoplasmic FMR1 interacting protein 2
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF5A eukaryotic translation initiation factor 5A
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FSTL1 follistatin-like 1
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GOLM1 golgi membrane protein 1
GPI glucose-6-phosphate isomerase
HACD2 3-hydroxyacyl-CoA dehydratase 2
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HOXC6 homeobox C6
HTRA1 HtrA serine peptidase 1
IFITM2 interferon induced transmembrane protein 2
IGFBP4 insulin-like growth factor binding protein 4
KRT10 keratin 10, type I
LTBP1 latent transforming growth factor beta binding protein 1
LYPLA1 lysophospholipase I
MSX1 msh homeobox 1
NPDC1 neural proliferation, differentiation and control, 1
NPY neuropeptide Y
PCDH9 protocadherin 9
PGAM1 phosphoglycerate mutase 1 (brain)
PLS3 plastin 3
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PRDX4 peroxiredoxin 4
PRKCZ protein kinase C, zeta
PTGDS prostaglandin D2 synthase 21kDa (brain)
RABAC1 Rab acceptor 1 (prenylated)
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
RPS26 ribosomal protein S26
RPS27L ribosomal protein S27-like
SCYL3 SCY1-like 3 (S. cerevisiae)
SEPP1 selenoprotein P, plasma, 1
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SKP1 S-phase kinase-associated protein 1
SPDEF SAM pointed domain containing ETS transcription factor
SPINK1 serine peptidase inhibitor, Kazal type 1
SRI sorcin
STOM stomatin
TACC1 transforming, acidic coiled-coil containing protein 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TECR trans-2,3-enoyl-CoA reductase
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS4 thrombospondin 4
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPBG trophoblast glycoprotein
TSPAN13 tetraspanin 13
TSPAN3 tetraspanin 3
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1