BRD-K17743697_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

96 genes differentially expressed following the BRD-K17743697_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AQP1 aquaporin 1 (Colton blood group)
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
CA12 carbonic anhydrase XII
CALML3 calmodulin-like 3
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1
CHGB chromogranin B
CHMP4A charged multivesicular body protein 4A
CLGN calmegin
CLIC4 chloride intracellular channel 4
COL4A6 collagen, type IV, alpha 6
CPB1 carboxypeptidase B1 (tissue)
CRISP3 cysteine-rich secretory protein 3
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GPRC5B G protein-coupled receptor, class C, group 5, member B
HBB hemoglobin, beta
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2BG histone cluster 1, H2bg
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ISG15 ISG15 ubiquitin-like modifier
KLK11 kallikrein-related peptidase 11
LAMP3 lysosomal-associated membrane protein 3
MAP7 microtubule-associated protein 7
MSMO1 methylsterol monooxygenase 1
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NTS neurotensin
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OLFM1 olfactomedin 1
OXTR oxytocin receptor
PDZK1 PDZ domain containing 1
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PROM1 prominin 1
RRAGD Ras-related GTP binding D
RSAD2 radical S-adenosyl methionine domain containing 2
SCGB2A2 secretoglobin, family 2A, member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SQLE squalene epoxidase
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
TCTN1 tectonic family member 1
TP63 tumor protein p63
USP18 ubiquitin specific peptidase 18
WWOX WW domain containing oxidoreductase

decreased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
BIN1 bridging integrator 1
CCL20 chemokine (C-C motif) ligand 20
CD9 CD9 molecule
CDC42 cell division cycle 42
CEMIP cell migration inducing protein, hyaluronan binding
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
DCN decorin
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
FOSL1 FOS-like antigen 1
G0S2 G0/G1 switch 2
GPRC5A G protein-coupled receptor, class C, group 5, member A
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HHEX hematopoietically expressed homeobox
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
ITGA6 integrin, alpha 6
KIF5C kinesin family member 5C
KRT18 keratin 18, type I
KRT19 keratin 19, type I
MCL1 myeloid cell leukemia 1
MMP12 matrix metallopeptidase 12
MYO1B myosin IB
NFE2L3 nuclear factor, erythroid 2-like 3
ODC1 ornithine decarboxylase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
STK17A serine/threonine kinase 17a
TCL1A T-cell leukemia/lymphoma 1A
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TJP2 tight junction protein 2