BRD-K17743125_belinostat_MCF7_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

276 genes differentially expressed following the BRD-K17743125_belinostat_MCF7_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ADGRE5 adhesion G protein-coupled receptor E5
ADRA2A adrenoceptor alpha 2A
AGR2 anterior gradient 2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
ALDOC aldolase C, fructose-bisphosphate
APOD apolipoprotein D
AREG amphiregulin
ARHGAP29 Rho GTPase activating protein 29
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ASMTL acetylserotonin O-methyltransferase-like
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin)
BTG1 B-cell translocation gene 1, anti-proliferative
BTN3A2 butyrophilin, subfamily 3, member A2
CA1 carbonic anhydrase I
CCL21 chemokine (C-C motif) ligand 21
CCL5 chemokine (C-C motif) ligand 5
CCNG2 cyclin G2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFD complement factor D (adipsin)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CIB1 calcium and integrin binding 1 (calmyrin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLIC5 chloride intracellular channel 5
CLU clusterin
CORO1A coronin, actin binding protein, 1A
CP ceruloplasmin (ferroxidase)
CPD carboxypeptidase D
CPM carboxypeptidase M
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CPVL carboxypeptidase, vitellogenic-like
CTSA cathepsin A
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
ECI2 enoyl-CoA delta isomerase 2
EDNRA endothelin receptor type A
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EVL Enah/Vasp-like
F13A1 coagulation factor XIII, A1 polypeptide
FAM46A family with sequence similarity 46, member A
FBLN5 fibulin 5
FLNA filamin A, alpha
FOXO4 forkhead box O4
FTH1 ferritin, heavy polypeptide 1
FUCA1 fucosidase, alpha-L- 1, tissue
FYB FYN binding protein
G6PD glucose-6-phosphate dehydrogenase
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GLRX glutaredoxin (thioltransferase)
GM2A GM2 ganglioside activator
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPM6A glycoprotein M6A
GPRC5B G protein-coupled receptor, class C, group 5, member B
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
GRN granulin
GSN gelsolin
GSTA4 glutathione S-transferase alpha 4
GULP1 GULP, engulfment adaptor PTB domain containing 1
HEBP1 heme binding protein 1
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
INSR insulin receptor
ISG15 ISG15 ubiquitin-like modifier
JAG1 jagged 1
JARID2 jumonji, AT rich interactive domain 2
KDM5B lysine (K)-specific demethylase 5B
KIAA0513 KIAA0513
KIF5C kinesin family member 5C
KLF6 Kruppel-like factor 6
LIMCH1 LIM and calponin homology domains 1
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRRC16A leucine rich repeat containing 16A
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN2B1 mannosidase, alpha, class 2B, member 1
MAOB monoamine oxidase B
MARCKSL1 MARCKS-like 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMD monocyte to macrophage differentiation-associated
MT1X metallothionein 1X
MVP major vault protein
MXI1 MAX interactor 1, dimerization protein
MYH11 myosin, heavy chain 11, smooth muscle
NDRG1 N-myc downstream regulated 1
NEU1 sialidase 1 (lysosomal sialidase)
NFIL3 nuclear factor, interleukin 3 regulated
NME7 NME/NM23 family member 7
NOTCH2 notch 2
NQO2 NAD(P)H dehydrogenase, quinone 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
OSR2 odd-skipped related transciption factor 2
PBX1 pre-B-cell leukemia homeobox 1
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PEG10 paternally expressed 10
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLIN2 perilipin 2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRAF2 PRA1 domain family, member 2
PRKCD protein kinase C, delta
PRKCZ protein kinase C, zeta
PRSS8 protease, serine, 8
PSAP prosaposin
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB9A RAB9A, member RAS oncogene family
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBM47 RNA binding motif protein 47
RHOB ras homolog family member B
RHOF ras homolog family member F (in filopodia)
RIOK3 RIO kinase 3
RNASET2 ribonuclease T2
RND3 Rho family GTPase 3
RNF11 ring finger protein 11
RPS11 ribosomal protein S11
RRAS related RAS viral (r-ras) oncogene homolog
RTN2 reticulon 2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCPEP1 serine carboxypeptidase 1
SDC4 syndecan 4
SEPP1 selenoprotein P, plasma, 1
SIX1 SIX homeobox 1
SKAP2 src kinase associated phosphoprotein 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC38A1 solute carrier family 38, member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNN stannin
SPTSSA serine palmitoyltransferase, small subunit A
SQSTM1 sequestosome 1
SRGN serglycin
STOM stomatin
STX1A syntaxin 1A (brain)
TCTA T-cell leukemia translocation altered
TFPI2 tissue factor pathway inhibitor 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMSB15A thymosin beta 15a
TNNT1 troponin T type 1 (skeletal, slow)
TOX3 TOX high mobility group box family member 3
TPP1 tripeptidyl peptidase I
TRAK2 trafficking protein, kinesin binding 2
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
TXNIP thioredoxin interacting protein
TXNRD1 thioredoxin reductase 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
VAMP8 vesicle-associated membrane protein 8
VDAC1 voltage-dependent anion channel 1
VIM vimentin
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
AK4 adenylate kinase 4
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ATF5 activating transcription factor 5
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
BID BH3 interacting domain death agonist
BTG3 BTG family, member 3
C1QBP complement component 1, q subcomponent binding protein
C6 complement component 6
CARKD carbohydrate kinase domain containing
CBFB core-binding factor, beta subunit
CD200 CD200 molecule
CD34 CD34 molecule
CD58 CD58 molecule
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHEK1 checkpoint kinase 1
CHIC2 cysteine-rich hydrophobic domain 2
CKAP4 cytoskeleton-associated protein 4
COMT catechol-O-methyltransferase
COPS3 COP9 signalosome subunit 3
COPS7A COP9 signalosome subunit 7A
CPE carboxypeptidase E
CTPS1 CTP synthase 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DUT deoxyuridine triphosphatase
EIF4A1 eukaryotic translation initiation factor 4A1
EMP1 epithelial membrane protein 1
EXOSC8 exosome component 8
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAIM Fas apoptotic inhibitory molecule
FAM129A family with sequence similarity 129, member A
FANCL Fanconi anemia, complementation group L
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GINS3 GINS complex subunit 3 (Psf3 homolog)
GPNMB glycoprotein (transmembrane) nmb
GRWD1 glutamate-rich WD repeat containing 1
GTPBP8 GTP-binding protein 8 (putative)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H4C histone cluster 1, H4c
HMGB1 high mobility group box 1
HMGB2 high mobility group box 2
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HOXB7 homeobox B7
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IFI16 interferon, gamma-inducible protein 16
IFRD2 interferon-related developmental regulator 2
ING3 inhibitor of growth family, member 3
JADE2 jade family PHD finger 2
KLK10 kallikrein-related peptidase 10
KRT13 keratin 13, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial)
LMNB1 lamin B1
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MICU2 mitochondrial calcium uptake 2
MINA MYC induced nuclear antigen
MPDU1 mannose-P-dolichol utilization defect 1
MRPL15 mitochondrial ribosomal protein L15
MXRA5 matrix-remodelling associated 5
NBN nibrin
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor
NUDT15 nudix (nucleoside diphosphate linked moiety X)-type motif 15
ODC1 ornithine decarboxylase 1
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PDLIM1 PDZ and LIM domain 1
PHF11 PHD finger protein 11
PKD2 polycystic kidney disease 2 (autosomal dominant)
PLAGL1 pleiomorphic adenoma gene-like 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
RAD51AP1 RAD51 associated protein 1
RPL10 ribosomal protein L10
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC35A5 solute carrier family 35, member A5
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SMC2 structural maintenance of chromosomes 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SRSF7 serine/arginine-rich splicing factor 7
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced
THBS2 thrombospondin 2
TIMELESS timeless circadian clock
TMEM5 transmembrane protein 5
TMPO thymopoietin
TMX4 thioredoxin-related transmembrane protein 4
TP53 tumor protein p53
TRIB2 tribbles pseudokinase 2
TUBB tubulin, beta class I
TUBB6 tubulin, beta 6 class V
TYMS thymidylate synthetase
UBE2J1 ubiquitin-conjugating enzyme E2, J1
USP1 ubiquitin specific peptidase 1
VRK2 vaccinia related kinase 2
ZWINT ZW10 interacting kinetochore protein