BRD-K17743125_belinostat_HT29_24_h_3.33_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K17743125_belinostat_HT29_24_h_3.33_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADD3 adducin 3 (gamma)
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase)
ALDOC aldolase C, fructose-bisphosphate
AMDHD2 amidohydrolase domain containing 2
ANOS1 anosmin 1
ARHGAP29 Rho GTPase activating protein 29
BAD BCL2-associated agonist of cell death
C14ORF132 chromosome 14 open reading frame 132
CAPG capping protein (actin filament), gelsolin-like
CCNG2 cyclin G2
CD14 CD14 molecule
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CRISP3 cysteine-rich secretory protein 3
CYFIP2 cytoplasmic FMR1 interacting protein 2
DAPK1 death-associated protein kinase 1
DBN1 drebrin 1
DMXL2 Dmx-like 2
ENO2 enolase 2 (gamma, neuronal)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FAM117A family with sequence similarity 117, member A
FCGBP Fc fragment of IgG binding protein
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GLRX glutaredoxin (thioltransferase)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
H1F0 H1 histone family, member 0
HOOK2 hook microtubule-tethering protein 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPB1 heat shock 27kDa protein 1
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDS iduronate 2-sulfatase
IFT57 intraflagellar transport 57
LRRC16A leucine rich repeat containing 16A
LTA4H leukotriene A4 hydrolase
MAN1A1 mannosidase, alpha, class 1A, member 1
MAN2B1 mannosidase, alpha, class 2B, member 1
MEGF9 multiple EGF-like-domains 9
METRN meteorin, glial cell differentiation regulator
MFAP5 microfibrillar associated protein 5
MID1 midline 1
MME membrane metallo-endopeptidase
MSX1 msh homeobox 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NAV2 neuron navigator 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC2 Niemann-Pick disease, type C2
PLA2G15 phospholipase A2, group XV
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PRSS23 protease, serine, 23
REG1A regenerating islet-derived 1 alpha
RTN3 reticulon 3
SDC2 syndecan 2
SEPHS2 selenophosphate synthetase 2
SNAP25 synaptosomal-associated protein, 25kDa
SNN stannin
SNX2 sorting nexin 2
SQSTM1 sequestosome 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1
THY1 Thy-1 cell surface antigen
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TPP1 tripeptidyl peptidase I
TRIM2 tripartite motif containing 2
TSPAN4 tetraspanin 4
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
VAT1 vesicle amine transport 1
WDR7 WD repeat domain 7
WDTC1 WD and tetratricopeptide repeats 1
WWOX WW domain containing oxidoreductase
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
ACAT1 acetyl-CoA acetyltransferase 1
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C1QBP complement component 1, q subcomponent binding protein
C7 complement component 7
CCL5 chemokine (C-C motif) ligand 5
CD38 CD38 molecule
CD48 CD48 molecule
CD58 CD58 molecule
CD69 CD69 molecule
CKS2 CDC28 protein kinase regulatory subunit 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYTIP cytohesin 1 interacting protein
DCTD dCMP deaminase
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FERMT1 fermitin family member 1
FGG fibrinogen gamma chain
FHL2 four and a half LIM domains 2
FZD10 frizzled class receptor 10
GPRC5A G protein-coupled receptor, class C, group 5, member A
GUSBP11 glucuronidase, beta pseudogene 11
HBB hemoglobin, beta
HN1L hematological and neurological expressed 1-like
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGF1 insulin-like growth factor 1 (somatomedin C)
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
INPP1 inositol polyphosphate-1-phosphatase
IPO13 importin 13
IRAK1 interleukin-1 receptor-associated kinase 1
ITGB5 integrin, beta 5
JADE2 jade family PHD finger 2
JCHAIN joining chain of multimeric IgA and IgM
KIAA0101 KIAA0101
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK6 kallikrein-related peptidase 6
KRT13 keratin 13, type I
LYPLA1 lysophospholipase I
MANSC1 MANSC domain containing 1
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MAPK13 mitogen-activated protein kinase 13
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta)
MSLN mesothelin
MSMB microseminoprotein, beta-
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NCAPD3 non-SMC condensin II complex, subunit D3
NME1 NME/NM23 nucleoside diphosphate kinase 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
PCSK6 proprotein convertase subtilisin/kexin type 6
PDLIM1 PDZ and LIM domain 1
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC35F2 solute carrier family 35, member F2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SORBS2 sorbin and SH3 domain containing 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SQLE squalene epoxidase
SRGN serglycin
STEAP1 six transmembrane epithelial antigen of the prostate 1
STEAP3 STEAP family member 3, metalloreductase
TFB2M transcription factor B2, mitochondrial
TM4SF1 transmembrane 4 L six family member 1
TP53 tumor protein p53
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
UBE2C ubiquitin-conjugating enzyme E2C
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)