BRD-K17497770_-666_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-K17497770_-666_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AIM1 absent in melanoma 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ANPEP alanyl (membrane) aminopeptidase
ANXA1 annexin A1
AREG amphiregulin
ASPN asporin
BTG2 BTG family, member 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CD36 CD36 molecule (thrombospondin receptor)
CD40 CD40 molecule, TNF receptor superfamily member 5
CDK14 cyclin-dependent kinase 14
COMP cartilage oligomeric matrix protein
COMT catechol-O-methyltransferase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FAM129A family with sequence similarity 129, member A
FRY furry homolog (Drosophila)
FTH1 ferritin, heavy polypeptide 1
GAGE3 G antigen 3
HEXA hexosaminidase A (alpha polypeptide)
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
IER5 immediate early response 5
IGKV4-1 immunoglobulin kappa variable 4-1
JAG1 jagged 1
LGALS2 lectin, galactoside-binding, soluble, 2
LGALS3 lectin, galactoside-binding, soluble, 3
LINC00341 long intergenic non-protein coding RNA 341
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP7 matrix metallopeptidase 7
PDLIM1 PDZ and LIM domain 1
PLBD1 phospholipase B domain containing 1
POSTN periostin, osteoblast specific factor
PRNP prion protein
RGCC regulator of cell cycle
RXRA retinoid X receptor, alpha
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPP1 secreted phosphoprotein 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TPP1 tripeptidyl peptidase I
WARS tryptophanyl-tRNA synthetase

decreased expression

Symbol Name
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ANXA3 annexin A3
ARMCX6 armadillo repeat containing, X-linked 6
BASP1 brain abundant, membrane attached signal protein 1
BIRC5 baculoviral IAP repeat containing 5
BUB3 BUB3 mitotic checkpoint protein
BZW1 basic leucine zipper and W2 domains 1
CD81 CD81 molecule
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COL4A2 collagen, type IV, alpha 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CSRP1 cysteine and glycine-rich protein 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DKK1 dickkopf WNT signaling pathway inhibitor 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FGB fibrinogen beta chain
FSTL1 follistatin-like 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP3 insulin-like growth factor binding protein 3
KAT6A K(lysine) acetyltransferase 6A
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NME4 NME/NM23 nucleoside diphosphate kinase 4
NREP neuronal regeneration related protein
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PPIF peptidylprolyl isomerase F
PRMT1 protein arginine methyltransferase 1
PSD3 pleckstrin and Sec7 domain containing 3
PTMA prothymosin, alpha
PUF60 poly-U binding splicing factor 60KDa
QDPR quinoid dihydropteridine reductase
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPS11 ribosomal protein S11
RUFY3 RUN and FYVE domain containing 3
SET SET nuclear proto-oncogene
TOP2B topoisomerase (DNA) II beta 180kDa
TPM1 tropomyosin 1 (alpha)
TUBB tubulin, beta class I
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
WTAP Wilms tumor 1 associated protein