BRD-K17497770_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K17497770_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABHD4 abhydrolase domain containing 4
ABLIM1 actin binding LIM protein 1
ADM adrenomedullin
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMDHD2 amidohydrolase domain containing 2
ANPEP alanyl (membrane) aminopeptidase
ASPH aspartate beta-hydroxylase
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALCOCO2 calcium binding and coiled-coil domain 2
CD163 CD163 molecule
CEP57 centrosomal protein 57kDa
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DHCR7 7-dehydrocholesterol reductase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC10 DnaJ (Hsp40) homolog, subfamily C, member 10
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EML3 echinoderm microtubule associated protein like 3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FGF13 fibroblast growth factor 13
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GABARAPL1 GABA(A) receptor-associated protein like 1
GATA6 GATA binding protein 6
GCLM glutamate-cysteine ligase, modifier subunit
GSTA1 glutathione S-transferase alpha 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-C major histocompatibility complex, class I, C
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IFRD1 interferon-related developmental regulator 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4
KDM3A lysine (K)-specific demethylase 3A
KRT6B keratin 6B, type II
KYNU kynureninase
LMCD1 LIM and cysteine-rich domains 1
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MAT2A methionine adenosyltransferase II, alpha
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MT1F metallothionein 1F
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEBL nebulette
NFIL3 nuclear factor, interleukin 3 regulated
NPR3 natriuretic peptide receptor 3
NQO2 NAD(P)H dehydrogenase, quinone 2
NRCAM neuronal cell adhesion molecule
NUCB2 nucleobindin 2
P4HB prolyl 4-hydroxylase, beta polypeptide
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCSK1 proprotein convertase subtilisin/kexin type 1
PGD phosphogluconate dehydrogenase
PLIN2 perilipin 2
PPAP2B phosphatidic acid phosphatase type 2B
PROM1 prominin 1
RIOK3 RIO kinase 3
S100A12 S100 calcium binding protein A12
SCRG1 stimulator of chondrogenesis 1
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3YL1 SH3 and SYLF domain containing 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SMOX spermine oxidase
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBI transforming growth factor, beta-induced, 68kDa
TKT transketolase
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TRIM16 tripartite motif containing 16
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VEGFA vascular endothelial growth factor A
VIM vimentin
VLDLR very low density lipoprotein receptor

decreased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ALB albumin
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
BCHE butyrylcholinesterase
BTG2 BTG family, member 2
C8ORF4 chromosome 8 open reading frame 4
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCL20 chemokine (C-C motif) ligand 20
CCNE2 cyclin E2
CD24 CD24 molecule
CDK1 cyclin-dependent kinase 1
CDK14 cyclin-dependent kinase 14
COL4A5 collagen, type IV, alpha 5
CTSH cathepsin H
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DNM1L dynamin 1-like
DPT dermatopontin
EFNA1 ephrin-A1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
FAIM Fas apoptotic inhibitory molecule
FBLN1 fibulin 1
GBAS glioblastoma amplified sequence
GUCY1B3 guanylate cyclase 1, soluble, beta 3
H2AFV H2A histone family, member V
HES1 hes family bHLH transcription factor 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
ISG15 ISG15 ubiquitin-like modifier
KIAA0101 KIAA0101
LAPTM4B lysosomal protein transmembrane 4 beta
LPAR6 lysophosphatidic acid receptor 6
LRRC17 leucine rich repeat containing 17
NR2F1 nuclear receptor subfamily 2, group F, member 1
NUSAP1 nucleolar and spindle associated protein 1
PEG10 paternally expressed 10
POSTN periostin, osteoblast specific factor
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PVALB parvalbumin
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SECISBP2L SECIS binding protein 2-like
SELENBP1 selenium binding protein 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SMYD3 SET and MYND domain containing 3
STK39 serine threonine kinase 39
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TMSB15A thymosin beta 15a
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)