BRD-K17497770_-666_ASC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

143 genes differentially expressed following the BRD-K17497770_-666_ASC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAT1 adenosine deaminase, tRNA-specific 1
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AMIGO2 adhesion molecule with Ig-like domain 2
ARHGAP32 Rho GTPase activating protein 32
ASNS asparagine synthetase (glutamine-hydrolyzing)
BAG3 BCL2-associated athanogene 3
BHLHE41 basic helix-loop-helix family, member e41
C1ORF116 chromosome 1 open reading frame 116
CA2 carbonic anhydrase II
CADM1 cell adhesion molecule 1
CD24 CD24 molecule
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLEC2B C-type lectin domain family 2, member B
CLEC5A C-type lectin domain family 5, member A
COL10A1 collagen, type X, alpha 1
CREG1 cellular repressor of E1A-stimulated genes 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYB561 cytochrome b561
EGFR epidermal growth factor receptor
EIF5 eukaryotic translation initiation factor 5
ENAH enabled homolog (Drosophila)
FCGBP Fc fragment of IgG binding protein
FOXF2 forkhead box F2
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GNLY granulysin
GOLM1 golgi membrane protein 1
GOLT1B golgi transport 1B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IGHMBP2 immunoglobulin mu binding protein 2
IL7R interleukin 7 receptor
KYNU kynureninase
LXN latexin
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP1 matrix metallopeptidase 1
MMP9 matrix metallopeptidase 9
MSH6 mutS homolog 6
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NID1 nidogen 1
P3H2 prolyl 3-hydroxylase 2
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFA platelet-derived growth factor alpha polypeptide
PPAP2C phosphatidic acid phosphatase type 2C
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC1 syndecan 1
SERINC5 serine incorporator 5
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX11 SRY (sex determining region Y)-box 11
SPINK1 serine peptidase inhibitor, Kazal type 1
SQSTM1 sequestosome 1
TGFBI transforming growth factor, beta-induced, 68kDa
TMEM30B transmembrane protein 30B
TNFAIP6 tumor necrosis factor, alpha-induced protein 6

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACLY ATP citrate lyase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIRF adipogenesis regulatory factor
ALDOC aldolase C, fructose-bisphosphate
ANXA6 annexin A6
APOE apolipoprotein E
AQP1 aquaporin 1 (Colton blood group)
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BPHL biphenyl hydrolase-like (serine hydrolase)
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CHRDL1 chordin-like 1
CIDEA cell death-inducing DFFA-like effector a
CRYAB crystallin, alpha B
CRYL1 crystallin, lambda 1
CST3 cystatin C
CXCL12 chemokine (C-X-C motif) ligand 12
CYB5R3 cytochrome b5 reductase 3
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
DEFB1 defensin, beta 1
DUSP4 dual specificity phosphatase 4
EBP emopamil binding protein (sterol isomerase)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FABP4 fatty acid binding protein 4, adipocyte
FAM162A family with sequence similarity 162, member A
FASN fatty acid synthase
FERMT2 fermitin family member 2
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
FOLR1 folate receptor 1 (adult)
FZD4 frizzled class receptor 4
GHR growth hormone receptor
GLDC glycine dehydrogenase (decarboxylating)
GLUL glutamate-ammonia ligase
GLYAT glycine-N-acyltransferase
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble)
GPX3 glutathione peroxidase 3
HADH hydroxyacyl-CoA dehydrogenase
HLA-B major histocompatibility complex, class I, B
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HRSP12 heat-responsive protein 12
IL6ST interleukin 6 signal transducer
INSIG1 insulin induced gene 1
ITGA7 integrin, alpha 7
KANK1 KN motif and ankyrin repeat domains 1
KIAA0125 KIAA0125
LEPR leptin receptor
LGALS1 lectin, galactoside-binding, soluble, 1
LPL lipoprotein lipase
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAOA monoamine oxidase A
MSMO1 methylsterol monooxygenase 1
NISCH nischarin
NOV nephroblastoma overexpressed
NPY1R neuropeptide Y receptor Y1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDLIM5 PDZ and LIM domain 5
PEBP1 phosphatidylethanolamine binding protein 1
PECR peroxisomal trans-2-enoyl-CoA reductase
PGM1 phosphoglucomutase 1
PIPOX pipecolic acid oxidase
PLIN1 perilipin 1
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PXMP2 peroxisomal membrane protein 2, 22kDa
RBP4 retinol binding protein 4, plasma
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPT11 septin 11
SORBS1 sorbin and SH3 domain containing 1
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
TIMP4 TIMP metallopeptidase inhibitor 4
TXNIP thioredoxin interacting protein