BRD-K16947188_N-(2-ethoxyphenyl)-4-morpholino-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-amine hw-gc-act07_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

72 genes differentially expressed following the BRD-K16947188_N-(2-ethoxyphenyl)-4-morpholino-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-amine hw-gc-act07_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ALB albumin
CASP1 caspase 1, apoptosis-related cysteine peptidase
CCNA1 cyclin A1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CXCL14 chemokine (C-X-C motif) ligand 14
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FBN2 fibrillin 2
FLNA filamin A, alpha
FRZB frizzled-related protein
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
HNMT histamine N-methyltransferase
HOMER3 homer scaffolding protein 3
IFI27 interferon, alpha-inducible protein 27
ITGB4 integrin, beta 4
LGALS3 lectin, galactoside-binding, soluble, 3
NDRG1 N-myc downstream regulated 1
PCP4 Purkinje cell protein 4
PEG10 paternally expressed 10
PFKL phosphofructokinase, liver
PLAGL1 pleiomorphic adenoma gene-like 1
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RHOBTB1 Rho-related BTB domain containing 1
RNF167 ring finger protein 167
S100P S100 calcium binding protein P
SDC1 syndecan 1
SERINC3 serine incorporator 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOX4 SRY (sex determining region Y)-box 4
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STK26 serine/threonine protein kinase 26
TGFBI transforming growth factor, beta-induced, 68kDa
TNS3 tensin 3
TXNIP thioredoxin interacting protein
UPP1 uridine phosphorylase 1
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGTR1 angiotensin II receptor, type 1
ALOX5AP arachidonate 5-lipoxygenase-activating protein
C8ORF4 chromosome 8 open reading frame 4
CNN3 calponin 3, acidic
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DEGS1 delta(4)-desaturase, sphingolipid 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GAS1 growth arrest-specific 1
GPATCH8 G patch domain containing 8
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOXB2 homeobox B2
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
KIAA0101 KIAA0101
KIAA0485 uncharacterized LOC57235
LIMA1 LIM domain and actin binding 1
MUC4 mucin 4, cell surface associated
MYH10 myosin, heavy chain 10, non-muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NR4A2 nuclear receptor subfamily 4, group A, member 2
PIP prolactin-induced protein
PRKCH protein kinase C, eta
RGS1 regulator of G-protein signaling 1
RGS10 regulator of G-protein signaling 10
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TCF4 transcription factor 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMEM230 transmembrane protein 230
TYMS thymidylate synthetase