BRD-K16947188_N-(2-ethoxyphenyl)-4-morpholino-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-amine hw-gc-act07_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K16947188_N-(2-ethoxyphenyl)-4-morpholino-6-(pyrrolidin-1-yl)-1,3,5-triazin-2-amine hw-gc-act07_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMPD3 adenosine monophosphate deaminase 3
BCL2A1 BCL2-related protein A1
BST2 bone marrow stromal cell antigen 2
CTSB cathepsin B
CXCL8 chemokine (C-X-C motif) ligand 8
DCT dopachrome tautomerase
DEFB1 defensin, beta 1
DHRS7 dehydrogenase/reductase (SDR family) member 7
DNTT DNA nucleotidylexotransferase
EDNRB endothelin receptor type B
GAS1 growth arrest-specific 1
GDF15 growth differentiation factor 15
GNPDA1 glucosamine-6-phosphate deaminase 1
GPR137B G protein-coupled receptor 137B
HMOX1 heme oxygenase 1
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IL13RA2 interleukin 13 receptor, alpha 2
IL6R interleukin 6 receptor
KAZN kazrin, periplakin interacting protein
KLK10 kallikrein-related peptidase 10
KLK11 kallikrein-related peptidase 11
KLK6 kallikrein-related peptidase 6
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MARCKSL1 MARCKS-like 1
MLANA melan-A
MSLN mesothelin
MXI1 MAX interactor 1, dimerization protein
NEFH neurofilament, heavy polypeptide
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NRIP3 nuclear receptor interacting protein 3
OAT ornithine aminotransferase
PEG3 paternally expressed 3
PLIN2 perilipin 2
PMEL premelanosome protein
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
RGS1 regulator of G-protein signaling 1
RNF144A ring finger protein 144A
RPL31 ribosomal protein L31
RRAGD Ras-related GTP binding D
SELL selectin L
SERINC5 serine incorporator 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A6 solute carrier family 16, member 6
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOAT1 sterol O-acyltransferase 1
SORD sorbitol dehydrogenase
SPON1 spondin 1, extracellular matrix protein
SQSTM1 sequestosome 1
SRPX sushi-repeat containing protein, X-linked
TMOD1 tropomodulin 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPP1 tripeptidyl peptidase I
TYR tyrosinase
VAT1 vesicle amine transport 1
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
WT1 Wilms tumor 1

decreased expression

Symbol Name
CA12 carbonic anhydrase XII
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CTSC cathepsin C
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
DPYSL2 dihydropyrimidinase-like 2
E2F2 E2F transcription factor 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GBP1 guanylate binding protein 1, interferon-inducible
GSE1 Gse1 coiled-coil protein
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
LMO3 LIM domain only 3 (rhombotin-like 2)
MAOA monoamine oxidase A
MBOAT7 membrane bound O-acyltransferase domain containing 7
NKG7 natural killer cell granule protein 7
NUAK1 NUAK family, SNF1-like kinase, 1
PER2 period circadian clock 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK2 polo-like kinase 2
POSTN periostin, osteoblast specific factor
PPL periplakin
PRR15L proline rich 15-like
SDC2 syndecan 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
TMEM176B transmembrane protein 176B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
VCAN versican
VSNL1 visinin-like 1
WIF1 WNT inhibitory factor 1