BRD-K16604360_R(-)-2,10,11-TRIHYDROXY-N-PROPYL-NORAPORPHINE_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

108 genes differentially expressed following the BRD-K16604360_R(-)-2,10,11-TRIHYDROXY-N-PROPYL-NORAPORPHINE_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOC1 apolipoprotein C-I
ASPN asporin
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CXCL14 chemokine (C-X-C motif) ligand 14
CXCR4 chemokine (C-X-C motif) receptor 4
FRY furry homolog (Drosophila)
GPX3 glutathione peroxidase 3
GRAMD4 GRAM domain containing 4
HMGB2 high mobility group box 2
HOXC10 homeobox C10
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP7 insulin-like growth factor binding protein 7
JAG1 jagged 1
LAMP5 lysosomal-associated membrane protein family, member 5
MMP12 matrix metallopeptidase 12
MN1 meningioma (disrupted in balanced translocation) 1
NID2 nidogen 2 (osteonidogen)
NXN nucleoredoxin
PLBD1 phospholipase B domain containing 1
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PXDN peroxidasin
RGS1 regulator of G-protein signaling 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SPON2 spondin 2, extracellular matrix protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMSB15A thymosin beta 15a
TNS3 tensin 3
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
BZW1 basic leucine zipper and W2 domains 1
C6ORF62 chromosome 6 open reading frame 62
CAPRIN1 cell cycle associated protein 1
CCND1 cyclin D1
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDC42SE1 CDC42 small effector 1
CFD complement factor D (adipsin)
CFH complement factor H
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
EGFR epidermal growth factor receptor
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
EIF5 eukaryotic translation initiation factor 5
ENO1 enolase 1, (alpha)
EZR ezrin
FAM46A family with sequence similarity 46, member A
FOLR1 folate receptor 1 (adult)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GLUL glutamate-ammonia ligase
HACD3 3-hydroxyacyl-CoA dehydratase 3
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
ILF3 interleukin enhancer binding factor 3, 90kDa
IQGAP1 IQ motif containing GTPase activating protein 1
ITGA6 integrin, alpha 6
LAMP1 lysosomal-associated membrane protein 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MUC1 mucin 1, cell surface associated
MYL9 myosin, light chain 9, regulatory
NDRG2 NDRG family member 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PDLIM5 PDZ and LIM domain 5
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
RAB2A RAB2A, member RAS oncogene family
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SEPT2 septin 2
SET SET nuclear proto-oncogene
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLPI secretory leukocyte peptidase inhibitor
SON SON DNA binding protein
SOX4 SRY (sex determining region Y)-box 4
SPTBN1 spectrin, beta, non-erythrocytic 1
SRSF6 serine/arginine-rich splicing factor 6
TAGLN2 transgelin 2
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMED2 transmembrane emp24 domain trafficking protein 2
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TSTA3 tissue specific transplantation antigen P35B
TWF1 twinfilin actin binding protein 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
VCAN versican
WDR1 WD repeat domain 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon