BRD-K16541732_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-K16541732_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ALCAM activated leukocyte cell adhesion molecule
ANXA3 annexin A3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BIK BCL2-interacting killer (apoptosis-inducing)
C10ORF10 chromosome 10 open reading frame 10
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHIC2 cysteine-rich hydrophobic domain 2
CHMP4A charged multivesicular body protein 4A
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP2 dual specificity phosphatase 2
DUSP6 dual specificity phosphatase 6
EGR1 early growth response 1
F2RL1 coagulation factor II (thrombin) receptor-like 1
FBP1 fructose-1,6-bisphosphatase 1
FNDC3B fibronectin type III domain containing 3B
FOSL1 FOS-like antigen 1
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPX2 glutathione peroxidase 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
IER3 immediate early response 3
IGKC immunoglobulin kappa constant
INHBA inhibin, beta A
JMJD1C jumonji domain containing 1C
KLF10 Kruppel-like factor 10
LAMP5 lysosomal-associated membrane protein family, member 5
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMCH1 LIM and calponin homology domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1B microtubule-associated protein 1B
MBNL2 muscleblind-like splicing regulator 2
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NAV2 neuron navigator 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SOX9 SRY (sex determining region Y)-box 9
SYNJ2 synaptojanin 2
TESC tescalcin
THBS1 thrombospondin 1
TOX3 TOX high mobility group box family member 3
TRIB3 tribbles pseudokinase 3

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ARHGAP29 Rho GTPase activating protein 29
CA12 carbonic anhydrase XII
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
CRABP2 cellular retinoic acid binding protein 2
DHRS2 dehydrogenase/reductase (SDR family) member 2
GATA3 GATA binding protein 3
GPX3 glutathione peroxidase 3
GRWD1 glutamate-rich WD repeat containing 1
HSPA1A heat shock 70kDa protein 1A
IGL immunoglobulin lambda locus
NR2F6 nuclear receptor subfamily 2, group F, member 6
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PPP1R3C protein phosphatase 1, regulatory subunit 3C
RAB13 RAB13, member RAS oncogene family
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
S100A8 S100 calcium binding protein A8
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
TNNT1 troponin T type 1 (skeletal, slow)
TP53I3 tumor protein p53 inducible protein 3
TRAPPC3 trafficking protein particle complex 3
TTC39A tetratricopeptide repeat domain 39A